Palmar plantar erythrodysesthesia natural history, complications, and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
==Natural History== | |||
Initially, the patient of Palmar Plantar Erythrosysesthesia experiences a sensation of numbness/tingling in the palms and soles. This progresses into a painful, tingling, symmetric, well-demarcated swelling with an erythematous plaques. It is followed by a phase of desquamation upon resolution.<ref name="urlAcral Erythema - Holland-Frei Cancer Medicine - NCBI Bookshelf2">{{cite web |url=https://www.ncbi.nlm.nih.gov/books/NBK12891/ |title=Acral Erythema - Holland-Frei Cancer Medicine - NCBI Bookshelf |format= |work= |accessdate=}}</ref> | |||
One of the complications associated with PPE is loss of fingerprints. It is documented in a patient who was treated with capecitabine and detained at an airport while travelling because of lack of finger prints.<ref name="pmid19470576">{{cite journal| author=Wong M, Choo SP, Tan EH| title=Travel warning with capecitabine. | journal=Ann Oncol | year= 2009 | volume= 20 | issue= 7 | pages= 1281 | pmid=19470576 | doi=10.1093/annonc/mdp278 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19470576 }}</ref> | |||
==Prognosis== | ==Prognosis== |
Revision as of 02:31, 26 September 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Natural History
Initially, the patient of Palmar Plantar Erythrosysesthesia experiences a sensation of numbness/tingling in the palms and soles. This progresses into a painful, tingling, symmetric, well-demarcated swelling with an erythematous plaques. It is followed by a phase of desquamation upon resolution.[1]
One of the complications associated with PPE is loss of fingerprints. It is documented in a patient who was treated with capecitabine and detained at an airport while travelling because of lack of finger prints.[2]
Prognosis
PPE variably recurs with resumption of chemotherapy. Long-term chemotherapy may also result in reversible palmoplantar keratoderma. Symptoms resolve 1-2 weeks after cessation of chemotherapy (Apisarnthanarax and Duvic 2003).
References
- ↑ "Acral Erythema - Holland-Frei Cancer Medicine - NCBI Bookshelf".
- ↑ Wong M, Choo SP, Tan EH (2009). "Travel warning with capecitabine". Ann Oncol. 20 (7): 1281. doi:10.1093/annonc/mdp278. PMID 19470576.