Autoimmune hemolytic anemia classification: Difference between revisions

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*Recognition by the reticuloendothelial system
*Recognition by the reticuloendothelial system
*Destruction by macrophages
*Destruction by macrophages
*Associated with cold agglutinin disease
*Associated with paroxysmal cold hemoglobinuria
*Associated with Mycoplasma infection
*Associated with malignancy
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Revision as of 23:55, 16 March 2018

Autoimmune hemolytic anemia Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assosciate Editor(s)-In-Chief: Prashanth Saddala M.B.B.S; Shyam Patel [2]

Overview

Classification

Category Features

Warm-antibody type

  • Due to IgG subtype
  • Extravascular hemolysis

Cold-antibody type

  • Due to IgM subtype
  • Intravascular hemolysis
  • Recognition by the reticuloendothelial system
  • Destruction by macrophages
  • Associated with cold agglutinin disease
  • Associated with paroxysmal cold hemoglobinuria
  • Associated with Mycoplasma infection
  • Associated with malignancy

Mixed warm-antibody and cold-antibody type

  • Due to IgM subtype
  • Mixed features


Intravascular haemolysis
Red blood cell lysis occurs in the circulation as a result of activation of the complement system cascade.

Extravascular haemolysis
Red Blood Cells that are coated with antibodies are specifically recognised in the reticuloendothelial system and destroyed by macrophages.

Subtypes

  • Cold antibody autoimmune hemolytic anemia
  • Mixed-type autoimmune hemolytic anemia

References

Template:Hematology


Template:WikiDoc Sources