Neonatal jaundice causes: Difference between revisions
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*[[Bile duct]] obstruction | *[[Bile duct]] obstruction | ||
=== Causes in Alphabetical Order === | ===Causes in Alphabetical Order=== | ||
{{columns-list|3| | |||
* Alloimmunity | |||
*Alpha-1-antitrypsin deficiency | |||
*Alpha-thalassemia | |||
*Arteriovenous malformation | |||
*Bile duct obstruction | |||
*Biliary atresia | |||
*Cephalhematoma | |||
*Crigler-Najjar syndrome | |||
*Cystic fibrosis | |||
*Galactosemia | |||
*Gilbert's syndrome | |||
*Glucose-6-phosphate dehydrogenase deficiency (also called G6PD deficiency) | |||
*Hemolytic disease of the newborn (ABO) | |||
*Hepatitis B | |||
*Hereditary elliptocytosis | |||
*Hydrochlorothiazide | |||
*Hypothyroidism | |||
*Losartan | |||
*Polycythemia | |||
*Pyruvate kinase deficiency | |||
*Rh disease | |||
*Sepsis | |||
*Spherocytosis | |||
*Splenomegaly | |||
*TORCH infections | |||
*Total parenteral nutrition | |||
}} | |||
==References== | ==References== |
Revision as of 19:06, 15 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Neonatal jaundice is caused by hemolysis of the RBCs mainly due to either intravascular causes or extravascular causes. Other causes include non-hemolytic causes such as cephalosporin induced jaundice, genetic mutations of the UGT enzyme, and hepatic causes.
Causes
Common causes
- Common causes of neonatal jaundice include the following:[1][2]
- Increase bilirubin production due to hemolysis. Hemolytic causes include:
- Intrinsic causes of hemolysis
- Systemic contitions
- Enzyme conditions
- Globin synthesis defect
- Increase bilirubin production due to hemolysis. Hemolytic causes include:
- Extrinsic causes of hemolysis
- Alloimmunity (The neonatal or cord blood gives a positive direct Coombs test and the maternal blood gives a positive indirect Coombs test)
- Hemolytic disease of the newborn (ABO)
- Rh disease
- Extrinsic causes of hemolysis
Less common causes
- Hepatic causes
- Infections
- Metabolic
- Drugs:
- Total parenteral nutrition
- Post-hepatic
- Bile duct obstruction
Causes in Alphabetical Order
The unnamed parameter 2= is no longer supported. Please see the documentation for {{columns-list}}.
3References
- ↑ Poland, R L (1980). "High milk lipase activity associated with breastmilk jaundice". Pediatr Res. 14: 1328–31. Unknown parameter
|coauthors=
ignored (help) - ↑ Murphy, J F (1981). "Pregnanediols and breast-milk jaundice". Arch Dis Child. 56: 474–76. Unknown parameter
|coauthors=
ignored (help) - ↑ Kumral, A (2009). "Breast milk jaundice correlates with high levels of epidermal growth factor". Pediatr Res. 66: 218–21. Unknown parameter
|coauthors=
ignored (help) - ↑ Arias, IM (1964). "Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feeding and a steroid, pregnane-3(alpha), 20(beta)-diol in maternal milk that inhibits glucuronide formation in vitro". J Clin Invest. 43: 2037–47. Unknown parameter
|coauthors=
ignored (help)