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{{ | '''Ubiquitin-conjugating enzyme E2 A''' is a [[protein]] that in humans is encoded by the ''UBE2A'' [[gene]].<ref name="pmid1559696">{{cite journal |vauthors=Koken MH, Smit EM, Jaspers-Dekker I, Oostra BA, Hagemeijer A, Bootsma D, Hoeijmakers JH | title = Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31 | journal = Genomics | volume = 12 | issue = 3 | pages = 447–53 |date=May 1992 | pmid = 1559696 | pmc = | doi =10.1016/0888-7543(92)90433-S }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7319| accessdate = }}</ref> | ||
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| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.<ref name="entrez" | | summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.<ref name="entrez"/> | ||
}} | }} | ||
==Interactions== | |||
UBE2A has been shown to [[Protein-protein interaction|interact]] with [[RAD18]]<ref name=pmid10908344>{{cite journal |last=Xin |first=H |authorlink= |author2=Lin W |author3=Sumanasekera W |author4=Zhang Y |author5=Wu X |author6=Wang Z |date=July 2000 |title=The human RAD18 gene product interacts with HHR6A and HHR6B |journal=Nucleic Acids Res. |volume=28 |issue=14 |pages=2847–54 |publisher= |location = ENGLAND| issn = | pmid = 10908344 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1093/nar/28.14.2847 |pmc=102657 }}</ref><ref name=pmid10884424>{{cite journal |last=Tateishi |first=S |authorlink= |author2=Sakuraba Y |author3=Masuyama S |author4=Inoue H |author5=Yamaizumi M |date=July 2000 |title=Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=14 |pages=7927–32 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10884424 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.97.14.7927 |pmc=16647 }}</ref> and [[P53]].<ref name=pmid12640129>{{cite journal |last=Lyakhovich |first=Alex |authorlink= |author2=Shekhar Malathy P V |date=April 2003 |title=Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response |journal=Mol. Cell. Biol. |volume=23 |issue=7 |pages=2463–75 |publisher= |location = United States| issn = 0270-7306| pmid = 12640129 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.23.7.2463-2475.2003 |pmc=150718 }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | *{{cite journal |vauthors=Koken MH, Reynolds P, Jaspers-Dekker I, etal |title=Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 20 |pages= 8865–9 |year= 1991 |pmid= 1717990 |doi=10.1073/pnas.88.20.8865 | pmc=52611 }} | ||
*{{cite journal |vauthors=Kato S, Sekine S, Oh SW, etal |title=Construction of a human full-length cDNA bank. |journal=Gene |volume=150 |issue= 2 |pages= 243–50 |year= 1995 |pmid= 7821789 |doi=10.1016/0378-1119(94)90433-2 }} | |||
*{{cite journal | *{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }} | ||
*{{cite journal | *{{cite journal |vauthors=Tateishi S, Sakuraba Y, Masuyama S, etal |title=Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 7927–32 |year= 2000 |pmid= 10884424 |doi=10.1073/pnas.97.14.7927 | pmc=16647 }} | ||
*{{cite journal | *{{cite journal |vauthors=Xin H, Lin W, Sumanasekera W, etal |title=The human RAD18 gene product interacts with HHR6A and HHR6B |journal=Nucleic Acids Res. |volume=28 |issue= 14 |pages= 2847–54 |year= 2000 |pmid= 10908344 |doi=10.1093/nar/28.14.2847 | pmc=102657 }} | ||
*{{cite journal | *{{cite journal |vauthors=Miura T, Klaus W, Ross A, etal |title=The NMR structure of the class I human ubiquitin-conjugating enzyme 2b |journal=J. Biomol. NMR |volume=22 |issue= 1 |pages= 89–92 |year= 2003 |pmid= 11885984 |doi=10.1023/A:1013807519703 }} | ||
*{{cite journal | *{{cite journal |vauthors=Shekhar MP, Lyakhovich A, Visscher DW, etal |title=Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation |journal=Cancer Res. |volume=62 |issue= 7 |pages= 2115–24 |year= 2002 |pmid= 11929833 |doi= }} | ||
*{{cite journal | *{{cite journal |vauthors=Sarcevic B, Mawson A, Baker RT, Sutherland RL |title=Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation |journal=EMBO J. |volume=21 |issue= 8 |pages= 2009–18 |year= 2002 |pmid= 11953320 |doi= 10.1093/emboj/21.8.2009 | pmc=125963 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Suzumori N, Burns KH, Yan W, Matzuk MM |title=RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 550–5 |year= 2003 |pmid= 12525704 |doi= 10.1073/pnas.0234474100 | pmc=141033 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Lyakhovich A, Shekhar MP |title=Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response |journal=Mol. Cell. Biol. |volume=23 |issue= 7 |pages= 2463–75 |year= 2003 |pmid= 12640129 |doi=10.1128/MCB.23.7.2463-2475.2003 | pmc=150718 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Kunapuli P, Somerville R, Still IH, Cowell JK |title=ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins |journal=Oncogene |volume=22 |issue= 22 |pages= 3417–23 |year= 2003 |pmid= 12776193 |doi= 10.1038/sj.onc.1206408 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | ||
*{{cite journal | *{{cite journal |vauthors=Nascimento RM, Otto PA, de Brouwer AP, Vianna-Morgante AM |title=UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome |journal=Am. J. Hum. Genet. |volume=79 |issue= 3 |pages= 549–55 |year= 2006 |pmid= 16909393 |doi= 10.1086/507047 | pmc=1559544 }} | ||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=7319}} | |||
{{Ubiquitin-conjugating enzymes}} | |||
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Revision as of 09:30, 17 September 2017
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
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| Wikidata | |||||||
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Ubiquitin-conjugating enzyme E2 A is a protein that in humans is encoded by the UBE2A gene.[1][2]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.[2]
Interactions
UBE2A has been shown to interact with RAD18[3][4] and P53.[5]
References
- ↑ Koken MH, Smit EM, Jaspers-Dekker I, Oostra BA, Hagemeijer A, Bootsma D, Hoeijmakers JH (May 1992). "Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31". Genomics. 12 (3): 447–53. doi:10.1016/0888-7543(92)90433-S. PMID 1559696.
- ↑ 2.0 2.1 "Entrez Gene: UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog)".
- ↑ Xin, H; Lin W; Sumanasekera W; Zhang Y; Wu X; Wang Z (July 2000). "The human RAD18 gene product interacts with HHR6A and HHR6B". Nucleic Acids Res. ENGLAND. 28 (14): 2847–54. doi:10.1093/nar/28.14.2847. PMC 102657. PMID 10908344.
- ↑ Tateishi, S; Sakuraba Y; Masuyama S; Inoue H; Yamaizumi M (July 2000). "Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (14): 7927–32. doi:10.1073/pnas.97.14.7927. ISSN 0027-8424. PMC 16647. PMID 10884424.
- ↑ Lyakhovich, Alex; Shekhar Malathy P V (April 2003). "Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response". Mol. Cell. Biol. United States. 23 (7): 2463–75. doi:10.1128/MCB.23.7.2463-2475.2003. ISSN 0270-7306. PMC 150718. PMID 12640129.
Further reading
- Koken MH, Reynolds P, Jaspers-Dekker I, et al. (1991). "Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 8865–9. doi:10.1073/pnas.88.20.8865. PMC 52611. PMID 1717990.
- Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Tateishi S, Sakuraba Y, Masuyama S, et al. (2000). "Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7927–32. doi:10.1073/pnas.97.14.7927. PMC 16647. PMID 10884424.
- Xin H, Lin W, Sumanasekera W, et al. (2000). "The human RAD18 gene product interacts with HHR6A and HHR6B". Nucleic Acids Res. 28 (14): 2847–54. doi:10.1093/nar/28.14.2847. PMC 102657. PMID 10908344.
- Miura T, Klaus W, Ross A, et al. (2003). "The NMR structure of the class I human ubiquitin-conjugating enzyme 2b". J. Biomol. NMR. 22 (1): 89–92. doi:10.1023/A:1013807519703. PMID 11885984.
- Shekhar MP, Lyakhovich A, Visscher DW, et al. (2002). "Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation". Cancer Res. 62 (7): 2115–24. PMID 11929833.
- Sarcevic B, Mawson A, Baker RT, Sutherland RL (2002). "Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation". EMBO J. 21 (8): 2009–18. doi:10.1093/emboj/21.8.2009. PMC 125963. PMID 11953320.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Suzumori N, Burns KH, Yan W, Matzuk MM (2003). "RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 550–5. doi:10.1073/pnas.0234474100. PMC 141033. PMID 12525704.
- Lyakhovich A, Shekhar MP (2003). "Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response". Mol. Cell. Biol. 23 (7): 2463–75. doi:10.1128/MCB.23.7.2463-2475.2003. PMC 150718. PMID 12640129.
- Kunapuli P, Somerville R, Still IH, Cowell JK (2003). "ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins". Oncogene. 22 (22): 3417–23. doi:10.1038/sj.onc.1206408. PMID 12776193.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Nascimento RM, Otto PA, de Brouwer AP, Vianna-Morgante AM (2006). "UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome". Am. J. Hum. Genet. 79 (3): 549–55. doi:10.1086/507047. PMC 1559544. PMID 16909393.
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