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{{Infobox_gene}}
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'''cAMP-dependent protein kinase catalytic subunit gamma''' is an [[enzyme]] that in humans is encoded by the ''PRKACG'' [[gene]].<ref name="pmid2342480">{{cite journal |vauthors=Beebe SJ, Oyen O, Sandberg M, Froysa A, Hansson V, Jahnsen T | title = Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase | journal = Mol Endocrinol | volume = 4 | issue = 3 | pages = 465–75 |date=June 1990 | pmid = 2342480 | pmc =  | doi =10.1210/mend-4-3-465 }}</ref><ref name="pmid9598317">{{cite journal |vauthors=Reinton N, Haugen TB, Orstavik S, Skalhegg BS, Hansson V, Jahnsen T, Tasken K | title = The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon | journal = Genomics | volume = 49 | issue = 2 | pages = 290–7 |date=August 1998 | pmid = 9598317 | pmc =  | doi = 10.1006/geno.1998.5240 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5568| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Protein kinase, cAMP-dependent, catalytic, gamma
| HGNCid = 9382
| Symbol = PRKACG
| AltSymbols =; KAPG
| OMIM = 176893
| ECnumber =
| Homologene = 55677
| MGIid =
  | GeneAtlas_image1 = PBB_GE_PRKACG_207228_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004691 |text = cAMP-dependent protein kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0031594 |text = neuromuscular junction}}
  | Process = {{GNF_GO|id=GO:0001707 |text = mesoderm formation}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0008584 |text = male gonad development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5568
    | Hs_Ensembl = ENSG00000165059
    | Hs_RefseqProtein = NP_002723
    | Hs_RefseqmRNA = NM_002732
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 70817241
    | Hs_GenLoc_end = 70818849
    | Hs_Uniprot = P22612
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Protein kinase, cAMP-dependent, catalytic, gamma''', also known as '''PRKACG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5568| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit.<ref name="entrez">{{cite web | title = Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5568| accessdate = }}</ref>
| summary_text = Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit.<ref name="entrez" />
}}
}}
==Interactions==
PRKACG has been shown to [[Protein-protein interaction|interact]] with [[Ryanodine receptor 2]].<ref name=pmid10830164>{{cite journal |last=Marx |first=S O |authorlink= |author2=Reiken S |author3=Hisamatsu Y |author4=Jayaraman T |author5=Burkhoff D |author6=Rosemblit N |author7=Marks A R  |date=May 2000 |title=PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts |journal=Cell |volume=101 |issue=4 |pages=365–76 |publisher= |location = UNITED STATES| issn = 0092-8674| pmid = 10830164 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0092-8674(00)80847-8 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Foss KB, Simard J, Bérubé D, ''et al.'' |title=Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13. |journal=Cytogenet. Cell Genet. |volume=60 |issue= 1 |pages= 22-5 |year= 1992 |pmid= 1339328 |doi= }}
*{{cite journal  | author=Foss KB |title=Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13 |journal=Cytogenet. Cell Genet. |volume=60 |issue= 1 |pages= 22–5 |year= 1992 |pmid= 1339328 |doi=10.1159/000133286 |name-list-format=vanc| author2=Simard J  | author3=Bérubé D  | display-authors=3  | last4=Beebe  | first4=S.J. | last5=Sandberg  | first5=M.  | last6=Grzeschik  | first6=K.-H.  | last7=Gagn&Eacute;  | first7=R.  | last8=Hansson | first8=V. | last9=Jahnsen  | first9=T.  }}
*{{cite journal | author=Hofmann B, Nishanian P, Baldwin RL, ''et al.'' |title=HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism. |journal=J. Immunol. |volume=145 |issue= 11 |pages= 3699-705 |year= 1991 |pmid= 1978848 |doi= }}
*{{cite journal  | author=Hofmann B |title=HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism |journal=J. Immunol. |volume=145 |issue= 11 |pages= 3699–705 |year= 1991 |pmid= 1978848 |doi=  |name-list-format=vanc| author2=Nishanian P | author3=Baldwin RL  | display-authors=3  | last4=Insixiengmay  | first4=P  | last5=Nel  | first5=A  | last6=Fahey  | first6=JL }}
*{{cite journal | author=Beebe SJ, Oyen O, Sandberg M, ''et al.'' |title=Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. |journal=Mol. Endocrinol. |volume=4 |issue= 3 |pages= 465-75 |year= 1990 |pmid= 2342480 |doi=  }}
*{{cite journal  | author=Hofmann B |title=Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6676–80 |year= 1993 |pmid= 7688126 |doi=10.1073/pnas.90.14.6676 | pmc=46995 |name-list-format=vanc| author2=Nishanian P | author3=Nguyen T  | display-authors=3  | last4=Insixiengmay  | first4=P  | last5=Fahey  | first5=JL }}
*{{cite journal  | author=Hofmann B, Nishanian P, Nguyen T, ''et al.'' |title=Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6676-80 |year= 1993 |pmid= 7688126 |doi=  }}
*{{cite journal  | author=Hofmann B |title=HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro |journal=AIDS |volume=8 |issue= 7 |pages= 1016–7 |year= 1994 |pmid= 7946090 |doi=10.1097/00002030-199407000-00025  |name-list-format=vanc| author2=Nishanian P  | author3=Fan J | display-authors=3  | last4=Nguyen  | first4=T.  | last5=Fahey  | first5=J. L.  }}
*{{cite journal  | author=Hofmann B, Nishanian P, Fan J, ''et al.'' |title=HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro. |journal=AIDS |volume=8 |issue= 7 |pages= 1016-7 |year= 1994 |pmid= 7946090 |doi=  }}
*{{cite journal  | author=Swingler S |title=The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix |journal=J. Virol. |volume=71 |issue= 6 |pages= 4372–7 |year= 1997 |pmid= 9151826 |doi= | pmc=191654  |name-list-format=vanc| author2=Gallay P | author3=Camaur D  | display-authors=3  | last4=Song  | first4=J  | last5=Abo  | first5=A  | last6=Trono  | first6=D  }}
*{{cite journal | author=Swingler S, Gallay P, Camaur D, ''et al.'' |title=The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix. |journal=J. Virol. |volume=71 |issue= 6 |pages= 4372-7 |year= 1997 |pmid= 9151826 |doi=  }}
*{{cite journal  |vauthors=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385–8 |year= 1997 |pmid= 9278385 |doi=10.1074/jbc.272.36.22385 }}
*{{cite journal  | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385-8 |year= 1997 |pmid= 9278385 |doi=  }}
*{{cite journal  | author=Liapi C |title=Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts |journal=J. Invest. Dermatol. |volume=110 |issue= 4 |pages= 332–7 |year= 1998 |pmid= 9540970 |doi= 10.1046/j.1523-1747.1998.00149.x |name-list-format=vanc| author2=Takahashi N  | author3=Raynaud F  | display-authors=3  | last4=Evain-Brion  | first4=Daniele  | last5=Anderson  | first5=Wayne B. }}
*{{cite journal  | author=Liapi C, Takahashi N, Raynaud F, ''et al.'' |title=Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts. |journal=J. Invest. Dermatol. |volume=110 |issue= 4 |pages= 332-7 |year= 1998 |pmid= 9540970 |doi= 10.1046/j.1523-1747.1998.00149.x }}
*{{cite journal  | author=Zidovetzki R |title=Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways |journal=AIDS Res. Hum. Retroviruses |volume=14 |issue= 10 |pages= 825–33 |year= 1998 |pmid= 9671211 |doi=10.1089/aid.1998.14.825 |name-list-format=vanc| author2=Wang JL  | author3=Chen P  | display-authors=3  | last4=Jeyaseelan  | first4=Raju  | last5=Hofman  | first5=Florence  }}
*{{cite journal | author=Reinton N, Haugen TB, Orstavik S, ''et al.'' |title=The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon. |journal=Genomics |volume=49 |issue= 2 |pages= 290-7 |year= 1998 |pmid= 9598317 |doi= 10.1006/geno.1998.5240 }}
*{{cite journal  | author=Mayne M |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease |journal=Neuroimmunomodulation |volume=5 |issue= 3–4 |pages= 184–92 |year= 1998 |pmid= 9730685 |doi=10.1159/000026336 |name-list-format=vanc| author2=Bratanich AC  | author3=Chen P  | display-authors=3  | last4=Rana  | first4=Farazana  | last5=Nath  | first5=Avindra  | last6=Power  | first6=Christopher  }}
*{{cite journal  | author=Zidovetzki R, Wang JL, Chen P, ''et al.'' |title=Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways. |journal=AIDS Res. Hum. Retroviruses |volume=14 |issue= 10 |pages= 825-33 |year= 1998 |pmid= 9671211 |doi=  }}
*{{cite journal  | author=Bodnar RJ |title=Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta) |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47080–7 |year= 2003 |pmid= 12361948 |doi= 10.1074/jbc.M208329200  |name-list-format=vanc| author2=Xi X  | author3=Li Z  | display-authors=3  | last4=Berndt  | first4=MC  | last5=Du  | first5=X }}
*{{cite journal  | author=Mayne M, Bratanich AC, Chen P, ''et al.'' |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184-92 |year= 1998 |pmid= 9730685 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS | last7=Wagner | first7=L | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Bodnar RJ, Xi X, Li Z, ''et al.'' |title=Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta). |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47080-7 |year= 2003 |pmid= 12361948 |doi= 10.1074/jbc.M208329200 }}
*{{cite journal | author=Cartier C |title=Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35211–9 |year= 2003 |pmid= 12842892 |doi= 10.1074/jbc.M301257200  |name-list-format=vanc| author2=Hemonnot B  | author3=Gay B  | display-authors=3  | last4=Bardy  | first4=M  | last5=Sanchiz  | first5=C  | last6=Devaux  | first6=C  | last7=Briant  | first7=L }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Masci AM |title=HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling |journal=J. Leukoc. Biol. |volume=74 |issue= 6 |pages= 1117–24 |year= 2004 |pmid= 12972513 |doi= 10.1189/jlb.0503239  |name-list-format=vanc| author2=Galgani M  | author3=Cassano S  | display-authors=3  | last4=De Simone  | first4=S  | last5=Gallo  | first5=A  | last6=De Rosa  | first6=V  | last7=Zappacosta  | first7=S  | last8=Racioppi  | first8=L }}
*{{cite journal | author=Cartier C, Hemonnot B, Gay B, ''et al.'' |title=Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35211-9 |year= 2003 |pmid= 12842892 |doi= 10.1074/jbc.M301257200 }}
*{{cite journal  |vauthors=Zhang W, Morris GZ, Beebe SJ |title=Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells |journal=Protein Expr. Purif. |volume=35 |issue= 1 |pages= 156–69 |year= 2004 |pmid= 15039079 |doi= 10.1016/j.pep.2004.01.006 }}
*{{cite journal  | author=Masci AM, Galgani M, Cassano S, ''et al.'' |title=HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling. |journal=J. Leukoc. Biol. |volume=74 |issue= 6 |pages= 1117-24 |year= 2004 |pmid= 12972513 |doi= 10.1189/jlb.0503239 }}
*{{cite journal  | author=Stevanin G |title=Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14 |journal=Arch. Neurol. |volume=61 |issue= 8 |pages= 1242–8 |year= 2004 |pmid= 15313841 |doi= 10.1001/archneur.61.8.1242  |name-list-format=vanc| author2=Hahn V  | author3=Lohmann E  | display-authors=3  | last4=Bouslam  | first4=N  | last5=Gouttard  | first5=M  | last6=Soumphonphakdy  | first6=C  | last7=Welter  | first7=ML  | last8=Ollagnon-Roman  | first8=E  | last9=Lemainque  | first9=A }}
*{{cite journal  | author=Zhang W, Morris GZ, Beebe SJ |title=Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells. |journal=Protein Expr. Purif. |volume=35 |issue= 1 |pages= 156-69 |year= 2004 |pmid= 15039079 |doi= 10.1016/j.pep.2004.01.006 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Stevanin G, Hahn V, Lohmann E, ''et al.'' |title=Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14. |journal=Arch. Neurol. |volume=61 |issue= 8 |pages= 1242-8 |year= 2004 |pmid= 15313841 |doi= 10.1001/archneur.61.8.1242 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 18:41, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

cAMP-dependent protein kinase catalytic subunit gamma is an enzyme that in humans is encoded by the PRKACG gene.[1][2][3]

Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit.[3]

Interactions

PRKACG has been shown to interact with Ryanodine receptor 2.[4]

References

  1. ↑ Beebe SJ, Oyen O, Sandberg M, Froysa A, Hansson V, Jahnsen T (June 1990). "Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase". Mol Endocrinol. 4 (3): 465–75. doi:10.1210/mend-4-3-465. PMID 2342480.
  2. ↑ Reinton N, Haugen TB, Orstavik S, Skalhegg BS, Hansson V, Jahnsen T, Tasken K (August 1998). "The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon". Genomics. 49 (2): 290–7. doi:10.1006/geno.1998.5240. PMID 9598317.
  3. ↑ 3.0 3.1 "Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma".
  4. ↑ Marx, S O; Reiken S; Hisamatsu Y; Jayaraman T; Burkhoff D; Rosemblit N; Marks A R (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell. UNITED STATES. 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. ISSN 0092-8674. PMID 10830164.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=PRKACG&oldid=1422685"