PRPF4B: Difference between revisions

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{{Infobox_gene}}
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'''Serine/threonine-protein kinase PRP4 homolog''' is an [[enzyme]] that in humans is encoded by the ''PRPF4B'' [[gene]].<ref name="pmid9628581">{{cite journal |vauthors=Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 1 | pages = 31–9 |date=Aug 1998 | pmid = 9628581 | pmc =  | doi =10.1093/dnares/5.1.31 }}</ref><ref name="pmid11418604">{{cite journal |vauthors=Kojima T, Zama T, Wada K, Onogi H, Hagiwara M | title = Cloning of human PRP4 reveals interaction with Clk1 | journal = J Biol Chem | volume = 276 | issue = 34 | pages = 32247–56 |date=Aug 2001 | pmid = 11418604 | pmc =  | doi = 10.1074/jbc.M103790200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8899| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = PRP4 pre-mRNA processing factor 4 homolog B (yeast)
| HGNCid = 17346
| Symbol = PRPF4B
| AltSymbols =; KIAA0536; PR4H; PRP4; PRP4H; PRP4K; dJ1013A10.1
| OMIM = 602338
| ECnumber =
| Homologene = 8472
| MGIid = 109584
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8899
    | Hs_Ensembl =   
    | Hs_RefseqProtein = NP_003904
    | Hs_RefseqmRNA = NM_003913
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 19134
    | Mm_Ensembl = ENSMUSG00000021413
    | Mm_RefseqmRNA = NM_013830
    | Mm_RefseqProtein = NP_038858
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 34882994
    | Mm_GenLoc_end = 34913528
    | Mm_Uniprot = Q6PBH0
  }}
}}
'''PRP4 pre-mRNA processing factor 4 homolog B (yeast)''', also known as '''PRPF4B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8899| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).<ref name="entrez">{{cite web | title = Entrez Gene: PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8899| accessdate = }}</ref>
| summary_text = Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).<ref name="entrez" />
}}
}}
==Interactions==
PRPF4B has been shown to [[Protein-protein interaction|interact]] with [[Pinin]].<ref name=pmid12077342>{{cite journal |last=Dellaire |first=Graham |authorlink= |author2=Makarov Evgeny M |author3=Cowger Jeff J M |author4=Longman Dasa |author5=Sutherland Heidi G E |author6=Lührmann Reinhard |author7=Torchia Joseph |author8=Bickmore Wendy A  |date=Jul 2002 |title=Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes |journal=Mol. Cell. Biol. |volume=22 |issue=14 |pages=5141–56 |publisher= |location = United States| issn = 0270-7306| pmid = 12077342 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.22.14.5141-5156.2002 |pmc=139773 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Schultz SJ, Nigg EA |title=Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. |journal=Cell Growth Differ. |volume=4 |issue= 10 |pages= 821-30 |year= 1994 |pmid= 8274451 |doi=  }}
*{{cite journal  |vauthors=Schultz SJ, Nigg EA |title=Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans |journal=Cell Growth Differ. |volume=4 |issue= 10 |pages= 821–30 |year= 1994 |pmid= 8274451 |doi=  }}
*{{cite journal | author=Gross T, Lützelberger M, Weigmann H, ''et al.'' |title=Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue. |journal=Nucleic Acids Res. |volume=25 |issue= 5 |pages= 1028-35 |year= 1997 |pmid= 9102632 |doi= }}
*{{cite journal   |vauthors=Gross T, Lützelberger M, Weigmann H, etal |title=Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue |journal=Nucleic Acids Res. |volume=25 |issue= 5 |pages= 1028–35 |year= 1997 |pmid= 9102632 |doi=10.1093/nar/25.5.1028  | pmc=146536 }}
*{{cite journal  | author=Nagase T, Ishikawa K, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31-9 |year= 1998 |pmid= 9628581 |doi=  }}
*{{cite journal  |vauthors=Huang Y, Deng T, Winston BW |title=Characterization of hPRP4 kinase activation: potential role in signaling |journal=Biochem. Biophys. Res. Commun. |volume=271 |issue= 2 |pages= 456–63 |year= 2000 |pmid= 10799319 |doi= 10.1006/bbrc.2000.2651 }}
*{{cite journal  | author=Huang Y, Deng T, Winston BW |title=Characterization of hPRP4 kinase activation: potential role in signaling. |journal=Biochem. Biophys. Res. Commun. |volume=271 |issue= 2 |pages= 456-63 |year= 2000 |pmid= 10799319 |doi= 10.1006/bbrc.2000.2651 }}
*{{cite journal   |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088  | pmc=1370266 }}
*{{cite journal | author=Kojima T, Zama T, Wada K, ''et al.'' |title=Cloning of human PRP4 reveals interaction with Clk1. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 32247-56 |year= 2001 |pmid= 11418604 |doi= 10.1074/jbc.M103790200 }}
*{{cite journal   |vauthors=Dellaire G, Makarov EM, Cowger JJ, etal |title=Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes |journal=Mol. Cell. Biol. |volume=22 |issue= 14 |pages= 5141–56 |year= 2002 |pmid= 12077342 |doi=10.1128/MCB.22.14.5141-5156.2002  | pmc=139773 }}
*{{cite journal  | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Dellaire G, Makarov EM, Cowger JJ, ''et al.'' |title=Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. |journal=Mol. Cell. Biol. |volume=22 |issue= 14 |pages= 5141-56 |year= 2002 |pmid= 12077342 |doi=  }}
*{{cite journal   |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal  |vauthors=Bennett EM, Lever AM, Allen JF |title=Human Immunodeficiency Virus Type 2 Gag Interacts Specifically with PRP4, a Serine-Threonine Kinase, and Inhibits Phosphorylation of Splicing Factor SF2 |journal=J. Virol. |volume=78 |issue= 20 |pages= 11303–12 |year= 2004 |pmid= 15452250 |doi= 10.1128/JVI.78.20.11303-11312.2004 | pmc=521795 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  | author=Bennett EM, Lever AM, Allen JF |title=Human immunodeficiency virus type 2 Gag interacts specifically with PRP4, a serine-threonine kinase, and inhibits phosphorylation of splicing factor SF2. |journal=J. Virol. |volume=78 |issue= 20 |pages= 11303-12 |year= 2004 |pmid= 15452250 |doi= 10.1128/JVI.78.20.11303-11312.2004 }}
*{{cite journal   |vauthors=Zhang Y, Wolf-Yadlin A, Ross PL, etal |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules |journal=Mol. Cell. Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal   |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Zhang Y, Wolf-Yadlin A, Ross PL, ''et al.'' |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell Proteomics |volume=4 |issue= 9 |pages= 1240-50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 }}
*{{cite journal   |vauthors=Nousiainen M, Silljé HH, Sauer G, etal |title=Phosphoproteome analysis of the human mitotic spindle |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Huang B, Ahn YT, McPherson L, etal |title=Interaction of PRP4 with Krüppel-Like Factor 13 Regulates CCL5 Transcription |journal=J. Immunol. |volume=178 |issue= 11 |pages= 7081–7 |year= 2007 |pmid= 17513757 |doi= 10.4049/jimmunol.178.11.7081| pmc=2674583 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal | author=Huang B, Ahn YT, McPherson L, ''et al.'' |title=Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription. |journal=J. Immunol. |volume=178 |issue= 11 |pages= 7081-7 |year= 2007 |pmid= 17513757 |doi=  }}
}}
}}
{{refend}}
{{refend}}
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{{Post transcriptional modification}}


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Revision as of 18:45, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.[1][2][3]

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).[3]

Interactions

PRPF4B has been shown to interact with Pinin.[4]

References

  1. ↑ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  2. ↑ Kojima T, Zama T, Wada K, Onogi H, Hagiwara M (Aug 2001). "Cloning of human PRP4 reveals interaction with Clk1". J Biol Chem. 276 (34): 32247–56. doi:10.1074/jbc.M103790200. PMID 11418604.
  3. ↑ 3.0 3.1 "Entrez Gene: PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast)".
  4. ↑ Dellaire, Graham; Makarov Evgeny M; Cowger Jeff J M; Longman Dasa; Sutherland Heidi G E; Lührmann Reinhard; Torchia Joseph; Bickmore Wendy A (Jul 2002). "Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes". Mol. Cell. Biol. United States. 22 (14): 5141–56. doi:10.1128/MCB.22.14.5141-5156.2002. ISSN 0270-7306. PMC 139773. PMID 12077342.

Further reading



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