Hemophilia A causes: Difference between revisions
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Females have two copies of the X chromosome, so if the factor VIII gene on one [[chromosome]] is defective, the gene on the other chromosome can do the job of making enough factor VIII. | Females have two copies of the X chromosome, so if the factor VIII gene on one [[chromosome]] is defective, the gene on the other chromosome can do the job of making enough factor VIII. | ||
Males, however, have only one X chromosome, so if the factor VIII gene on that chromosome is defective, they will have | Males, however, have only one X chromosome, so if the factor VIII gene on that chromosome is defective, they will have Hemophilia A. Therefore, most people with hemophilia A are male. | ||
If a woman has a defective factor VIII gene, she is considered a carrier. This means the defective gene can be passed down to her children. | If a woman has a defective factor VIII gene, she is considered a carrier. This means the defective gene can be passed down to her children. | ||
Revision as of 08:32, 27 March 2017
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Hemophilia A Microchapters |
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Hemophilia A causes On the Web |
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American Roentgen Ray Society Images of Hemophilia A causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Fahd Yunus, M.D. [2]
Overview
Hemophilia A is caused by an inherited X-linked recessive trait, with the defective gene located on the X chromosome.
Causes
Females have two copies of the X chromosome, so if the factor VIII gene on one chromosome is defective, the gene on the other chromosome can do the job of making enough factor VIII.
Males, however, have only one X chromosome, so if the factor VIII gene on that chromosome is defective, they will have Hemophilia A. Therefore, most people with hemophilia A are male.
If a woman has a defective factor VIII gene, she is considered a carrier. This means the defective gene can be passed down to her children.
Boys born to a woman who carries the defective gene have a 50% chance of having hemophilia A, while their daughters have a 50% chance of being a carrier.
All female children of men with hemophilia A carry the defective gene.