Japanese encephalitis causes: Difference between revisions

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{{Japanese encephalitis}}
{{Japanese encephalitis}}
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==Overview==
Japanese encephalitis may be caused by Japanese encephalitis virus. Japanese encephalitis virus is closely related to the [[West Nile virus]], [[Dengue virus]], [[Murray Valley encephalitis virus]], and [[St. Louis encephalitis]] virus.


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==Causes==
==Causes==
The causative agent, Japanese encephalitis virus is an [[enveloped virus]] of the [[genus]] [[flavivirus]]; it is closely related to the [[West Nile virus]], [[Murray Valley encephalitis virus]] and [[St. Louis encephalitis]] virus. All members in the serogroup have avian [[vertebrate]] [[host (biology)|hosts]] and are [[vector]]ed by Culex spp mosquitoes. JEV has also occasionally been recovered from Aedes spp mosquitoes. The virus is a 40-50 nm [[enveloped virus|enveloped]], [[Positive-sense ssRNA virus|positive-sense single stranded RNA]] virus, with an isometric 30 nm [[nucleocapsid]] core. The envelope is spiked with a mature [[membrane protein|membrane]] (M) protein and a [[glycosylated]] envelope (E) protein which is stabilized by disulfide bonds and comprises three domains (I, II and III) involved in [[antigen]]ic properties, [[cell receptor]] binding and penetration of the [[virion]] into the host-cell. [[Positive-sense ssRNA virus|Positive-sense single stranded RNA]] [[genome]] is packaged in the [[capsid]], formed by the capsid protein. The outer [[envelope (biology)|envelope]] is formed by envelope (E) protein and is the protective [[antigen]]. It aids in entry of the virus to the inside of the cell. The 10,976 [[base pair|bases]] long single-stranded viral [[RNA]] encodes an uninterrupted [[open reading frame]] that is [[translation|translated]] into a [[protein precursor|polyprotein precursor]] eventually processed into capsid (C) pre-M and E [[Structural Classification of Proteins|structural proteins]] and into seven non-structural proteins (NS1, NS2a, NS2b, NS3, N4a, NS4b, NS5). NS1 is produced as secretory form also. NS3 is a putative [[helicase]], and NS5 is the viral [[polymerase]]. It has been noted that the Japanese encephalitis virus (JEV) infects the [[lumen]] of the [[endoplasmic reticulum]] (ER) and rapidly accumulates substantial amounts of viral proteins for the JEV.
Japanese encephalitis may be caused by Japanese encephalitis virus. Japanese encephalitis virus is closely related to the [[West Nile virus]], [[Dengue virus]], [[Murray Valley encephalitis virus]], and [[St. Louis encephalitis]] virus.  


==References==
==References==
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{{Reflist|2}}
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Revision as of 15:04, 12 April 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Anthony Gallo, B.S. [2]

Overview

Japanese encephalitis may be caused by Japanese encephalitis virus. Japanese encephalitis virus is closely related to the West Nile virus, Dengue virus, Murray Valley encephalitis virus, and St. Louis encephalitis virus.

Causes

Japanese encephalitis may be caused by Japanese encephalitis virus. Japanese encephalitis virus is closely related to the West Nile virus, Dengue virus, Murray Valley encephalitis virus, and St. Louis encephalitis virus.

References


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