Large cell carcinoma of the lung overview: Difference between revisions

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==Classification==
==Classification==


According to the World Health Organization (WHO), large cell carcinoma of the lung can be classified into 6 sub-types: giant-cell carcinoma of the lung, basaloid large cell carcinoma of the lung, clear cell carcinoma of the lung, lymphoepithelioma-like carcinoma of the lung, large-cell lung carcinoma with rhabdoid phenotype, and large cell neuroendocrine carcinoma of the lung


==Pathophysiology==
==Pathophysiology==
On micropathology, large cell  carcinoma of the lung is characterized by the larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of "salt-and-pepper" chromatin




==Causes==
==Causes==


The most important cause in the development of large cell carcinoma of the lung is cigarette smoking.




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==Epidemiology and Demographics==
==Epidemiology and Demographics==


 
Large cell lung cancer accounts for 5% and 10% of all lung cancers.


==Risk Factors==
==Risk Factors==

Revision as of 14:19, 8 March 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

Historical Perspective

Classification

According to the World Health Organization (WHO), large cell carcinoma of the lung can be classified into 6 sub-types: giant-cell carcinoma of the lung, basaloid large cell carcinoma of the lung, clear cell carcinoma of the lung, lymphoepithelioma-like carcinoma of the lung, large-cell lung carcinoma with rhabdoid phenotype, and large cell neuroendocrine carcinoma of the lung

Pathophysiology

On micropathology, large cell carcinoma of the lung is characterized by the larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of "salt-and-pepper" chromatin


Causes

The most important cause in the development of large cell carcinoma of the lung is cigarette smoking.


Differentiating Large Cell Carcinoma of the Lung from other Diseases

Epidemiology and Demographics

Large cell lung cancer accounts for 5% and 10% of all lung cancers.

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Biopsy

Treatment

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Surgery

Primary Prevention

Secondary Prevention

References


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