Extramammary Paget's disease medical therapy: Difference between revisions

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==Overview==
==Overview==
Chemotherapy therapy with either 5-fluorouracil, imiquimod  cream, or the combination of paclitaxel and trastuzumab may be helpful in the treatment of extramammary Paget's disease.
Chemotherapy therapy with either 5-fluorouracil, imiquimod  cream, or the combination of paclitaxel and trastuzumab may be helpful in the treatment of extramammary Paget's disease.<ref name="pmid19691751">{{cite journal| author=Takahagi S, Noda H, Kamegashira A, Madokoro N, Hori I, Shindo H et al.| title=Metastatic extramammary Paget's disease treated with paclitaxel and trastuzumab combination chemotherapy. | journal=J Dermatol | year= 2009 | volume= 36 | issue= 8 | pages= 457-61 | pmid=19691751 | doi=10.1111/j.1346-8138.2009.00676.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19691751  }} </ref><ref name="pmid19840203">{{cite journal| author=Sendagorta E, Herranz P, Feito M, Ramírez P, Floristán U, Feltes R et al.| title=Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod--proposal of a therapeutic schedule. | journal=J Eur Acad Dermatol Venereol | year= 2010 | volume= 24 | issue= 4 | pages= 490-2 | pmid=19840203 | doi=10.1111/j.1468-3083.2009.03451.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19840203  }} </ref><ref name="pmid25259595">{{cite journal| author=Marchitelli C, Peremateu MS, Sluga MC, Berasategui MT, Lopez DG, Wernicke A et al.| title=Treatment of primary vulvar paget disease with 5% imiquimod cream. | journal=J Low Genit Tract Dis | year= 2014 | volume= 18 | issue= 4 | pages= 347-50 | pmid=25259595 | doi=10.1097/LGT.0000000000000053 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25259595  }} </ref><ref name="pmid19862365">{{cite journal| author=Beleznay KM, Levesque MA, Gill S| title=Response to 5-fluorouracil in metastatic extramammary Paget disease of the scrotum presenting as pancytopenia and back pain. | journal=Curr Oncol | year= 2009 | volume= 16 | issue= 5 | pages= 81-3 | pmid=19862365 | doi= | pmc=PMC2768510 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19862365  }} </ref>


==Medical Therapy==
==Medical Therapy==
Patients with extramammary Paget's disease have many treatment options. The selection depends on the stage of the tumor. The options are surgery, radiation therapy, or a combination of these methods. Before treatment starts, ask your health care team about possible side effects and how treatment may change your normal activities. Because cancer treatments often damage healthy cells and tissues, side effects are common. Side effects may not be the same for each person, and they may change from one treatment session to the next.
The following medical therapies have been studied for the treatment of extramammary Paget's disease:<ref name="pmid19691751">{{cite journal| author=Takahagi S, Noda H, Kamegashira A, Madokoro N, Hori I, Shindo H et al.| title=Metastatic extramammary Paget's disease treated with paclitaxel and trastuzumab combination chemotherapy. | journal=J Dermatol | year= 2009 | volume= 36 | issue= 8 | pages= 457-61 | pmid=19691751 | doi=10.1111/j.1346-8138.2009.00676.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19691751  }} </ref><ref name="pmid19840203">{{cite journal| author=Sendagorta E, Herranz P, Feito M, Ramírez P, Floristán U, Feltes R et al.| title=Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod--proposal of a therapeutic schedule. | journal=J Eur Acad Dermatol Venereol | year= 2010 | volume= 24 | issue= 4 | pages= 490-2 | pmid=19840203 | doi=10.1111/j.1468-3083.2009.03451.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19840203  }} </ref><ref name="pmid25259595">{{cite journal| author=Marchitelli C, Peremateu MS, Sluga MC, Berasategui MT, Lopez DG, Wernicke A et al.| title=Treatment of primary vulvar paget disease with 5% imiquimod cream. | journal=J Low Genit Tract Dis | year= 2014 | volume= 18 | issue= 4 | pages= 347-50 | pmid=25259595 | doi=10.1097/LGT.0000000000000053 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25259595  }} </ref><ref name="pmid19862365">{{cite journal| author=Beleznay KM, Levesque MA, Gill S| title=Response to 5-fluorouracil in metastatic extramammary Paget disease of the scrotum presenting as pancytopenia and back pain. | journal=Curr Oncol | year= 2009 | volume= 16 | issue= 5 | pages= 81-3 | pmid=19862365 | doi= | pmc=PMC2768510 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19862365  }} </ref>
*[[5-fluorouracil]]
*[[Imiquimod]]
*Combination of [[paclitaxel]] and [[trastuzumab]]
 
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 19:03, 5 February 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Chemotherapy therapy with either 5-fluorouracil, imiquimod cream, or the combination of paclitaxel and trastuzumab may be helpful in the treatment of extramammary Paget's disease.[1][2][3][4]

Medical Therapy

The following medical therapies have been studied for the treatment of extramammary Paget's disease:[1][2][3][4]

References

  1. 1.0 1.1 Takahagi S, Noda H, Kamegashira A, Madokoro N, Hori I, Shindo H; et al. (2009). "Metastatic extramammary Paget's disease treated with paclitaxel and trastuzumab combination chemotherapy". J Dermatol. 36 (8): 457–61. doi:10.1111/j.1346-8138.2009.00676.x. PMID 19691751.
  2. 2.0 2.1 Sendagorta E, Herranz P, Feito M, Ramírez P, Floristán U, Feltes R; et al. (2010). "Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod--proposal of a therapeutic schedule". J Eur Acad Dermatol Venereol. 24 (4): 490–2. doi:10.1111/j.1468-3083.2009.03451.x. PMID 19840203.
  3. 3.0 3.1 Marchitelli C, Peremateu MS, Sluga MC, Berasategui MT, Lopez DG, Wernicke A; et al. (2014). "Treatment of primary vulvar paget disease with 5% imiquimod cream". J Low Genit Tract Dis. 18 (4): 347–50. doi:10.1097/LGT.0000000000000053. PMID 25259595.
  4. 4.0 4.1 Beleznay KM, Levesque MA, Gill S (2009). "Response to 5-fluorouracil in metastatic extramammary Paget disease of the scrotum presenting as pancytopenia and back pain". Curr Oncol. 16 (5): 81–3. PMC 2768510. PMID 19862365.


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