Myxoma classification: Difference between revisions

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* Based on the location and biological behavior of symptoms, cardiac myxomas may be classified into two groups: '''typical''' and '''atypical'''. In typical cases, cardiac myxomas are almost always single, and there is a striking predilection for the left atrium, with approximately 75-86% occurring there.
* Based on the location and biological behavior of symptoms, cardiac myxomas may be classified into two groups: '''typical''' and '''atypical'''. In typical cases, cardiac myxomas are almost always single, and there is a striking predilection for the left atrium, with approximately 75-86% occurring there.


* In atypical cases, presentation is usually early and multicentricity is more common. They are more frequently located on the right side of the heart (38%), or in the [[left ventricle]] (5%). <ref> Cardiac Myxoma.Radiopedia.URL http://radiopaedia.org/articles/cardiac-myxoma accessed on November 13,2015 </ref> <ref name="pmid10903697">{{cite journal |vauthors=Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR |title=Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation |journal=Radiographics |volume=20 |issue=4 |pages=1073–103; quiz 1110–1, 1112 |year=2000 |pmid=10903697 |doi=10.1148/radiographics.20.4.g00jl081073 |url=}}</ref> There is also recurrence after [[surgical]] excision (12%–22%) and an association with other conditions, such as the [[Carney complex]]. Among patients with this syndrome, they tend to be younger, male, and have familial predisposition for cardiac myxoma.<ref name|classification="pmid10903697">{{cite journal |vauthors=Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR |title=Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation |journal=Radiographics |volume=20 |issue=4 |pages=1073–103; quiz 1110–1, 1112 |year=2000 |pmid=10903697 |doi=10.1148/radiographics.20.4.g00jl081073 |url=}}</ref>
* In atypical cases, presentation is usually early and multicentricity is more common. They are more frequently located on the right side of the heart (38%), or in the [[left ventricle]] (5%).<ref name="pmid10903697">{{cite journal |vauthors=Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR |title=Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation |journal=Radiographics |volume=20 |issue=4 |pages=1073–103; quiz 1110–1, 1112 |year=2000 |pmid=10903697 |doi=10.1148/radiographics.20.4.g00jl081073 |url=}}</ref><ref> Cardiac Myxoma.Radiopedia.URL http://radiopaedia.org/articles/cardiac-myxoma accessed on November 13,2015 </ref> There is also recurrence after [[surgical]] excision (12%–22%) and an association with other conditions, such as the [[Carney complex]]. Among patients with this syndrome, they tend to be younger, male, and have familial predisposition for cardiac myxoma.<ref name|classification="pmid10903697">{{cite journal |vauthors=Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR |title=Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation |journal=Radiographics |volume=20 |issue=4 |pages=1073–103; quiz 1110–1, 1112 |year=2000 |pmid=10903697 |doi=10.1148/radiographics.20.4.g00jl081073 |url=}}</ref>


* Distribution:
* Distribution:

Revision as of 23:43, 16 December 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

Cardiac myxomas are classified by the World Health Organization (WHO) histological classification of tumors of the heart, as "Benign tumors and tumor-like lesions" and categorized into a type of pluripotent mesenchymal tumor. According to the WHO, cardiac myxoma is a neoplasm composed of stellate to plump, cytologically bland mesenchymal cells set in a myxoid stroma.[1][2][3]

Classification

  • Based on the location and biological behavior of symptoms, cardiac myxomas may be classified into two groups: typical and atypical. In typical cases, cardiac myxomas are almost always single, and there is a striking predilection for the left atrium, with approximately 75-86% occurring there.
  • In atypical cases, presentation is usually early and multicentricity is more common. They are more frequently located on the right side of the heart (38%), or in the left ventricle (5%).[3][4] There is also recurrence after surgical excision (12%–22%) and an association with other conditions, such as the Carney complex. Among patients with this syndrome, they tend to be younger, male, and have familial predisposition for cardiac myxoma.[5]
  • Distribution:
    • Atria (95%)
      • Left (75%)
      • Right (20%)
    • Ventricles (5%)
  • There is no established histological differentiation between both type of cardiac myxomas (typical and atypical).[6]

References

  1. Amano J, Nakayama J, Yoshimura Y, Ikeda U (2013). "Clinical classification of cardiovascular tumors and tumor-like lesions, and its incidences". Gen Thorac Cardiovasc Surg. 61 (8): 435–47. doi:10.1007/s11748-013-0214-8. PMC 3732772. PMID 23460447.
  2. cite journal |vauthors=Wold LE, Lie JT |title=Cardiac myxomas: a clinicopathologic profile |journal=Am. J. Pathol. |volume=101 |issue=1 |pages=219–40 |year=1980 |pmid=7446701 |pmc=1903582 |doi= |url=}
  3. 3.0 3.1 Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR (2000). "Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation". Radiographics. 20 (4): 1073–103, quiz 1110–1, 1112. doi:10.1148/radiographics.20.4.g00jl081073. PMID 10903697.
  4. Cardiac Myxoma.Radiopedia.URL http://radiopaedia.org/articles/cardiac-myxoma accessed on November 13,2015
  5. Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR (2000). "Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation". Radiographics. 20 (4): 1073–103, quiz 1110–1, 1112. doi:10.1148/radiographics.20.4.g00jl081073. PMID 10903697.
  6. McCarthy PM, Piehler JM, Schaff HV, Pluth JR, Orszulak TA, Vidaillet HJ, Carney JA (1986). "The significance of multiple, recurrent, and "complex" cardiac myxomas". J. Thorac. Cardiovasc. Surg. 91 (3): 389–96. PMID 3951243.