Epidural abscess other diagnostic studies: Difference between revisions

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{{Epidural abscess}}
{{Epidural abscess}}
{{CMG}}; {{AE}} {{JS}}
{{CMG}} {{AE}} {{JS}}; {{AG}}


==Overview==
==Overview==
An epidural abscess is a rare [[suppurative]] [[infection]] of the [[central nervous system]], a collection of [[pus]] localised in the [[epidural space]] lying outside the [[dura mater]], which accounts for less than 2% of focal [[CNS]] infections. <ref>{{Cite book  | last1 = Longo | first1 = Dan L. (Dan Louis) | title = Harrison's principles of internal medici | date = 2012 | publisher = McGraw-Hill | location = New York | isbn = 978-0-07-174889-6 | pages =  }}</ref> It may occur in two different places: [[intracranial space|intracranially]] or in the [[spinal canal]].  Because the initial [[symptoms]] and clinical characteristics are not always identical, and are similar to the ones in other diseases, along with the fact that they are both rare conditions, the final [[diagnosis]] might be delayed in time. This late [[diagnosis]] comes at great cost to the patient, since it is usually accompanied by a bad [[prognosis]] and severe [[complications]] with a potential fatal outcome. The [[diagnosis]] of [[epidural abscess]] should be first suspected from the clinical findings, being posteriorly supported by laboratory tests and imaging studies, however it can only be confirmed after [[surgical]] drainage and proper study of the collected material. The laboratory tests despite helpful, are not diagnostic and should always be used alongside with history taking, clinical examination and imaging studies. According to the location of the collection, the [[abscess]] may have different origins, different organisms involved, [[symptoms]],  evolutions, [[complications]] and therapeutical techniques. <ref name="DannerHartman1987">{{cite journal|last1=Danner|first1=R. L.|last2=Hartman|first2=B. J.|title=Update of Spinal Epidural Abscess: 35 Cases and Review of the Literature|journal=Clinical Infectious Diseases|volume=9|issue=2|year=1987|pages=265–274|issn=1058-4838|doi=10.1093/clinids/9.2.265}}</ref><ref name="Darouiche2006">{{cite journal|last1=Darouiche|first1=Rabih O.|title=Spinal Epidural Abscess|journal=New England Journal of Medicine|volume=355|issue=19|year=2006|pages=2012–2020|issn=0028-4793|doi=10.1056/NEJMra055111}}</ref>
[[Lumbar puncture]] is likely not helpful in the diagnosis of epidural abscess.


==Lumbar Puncture==
==Other Diagnostic Studies==
[[CSF]] study is not a routine study, not only because it offers little information, but also because it has risks associated. It should be analyzed only when [[myelography]] is performed. About 3/4 of patients whose CSF is studied show:
===Lumbar Puncture===
*high [[protein]] level
[[Lumbar puncture]] is likely not helpful in the diagnosis of epidural abscess. [[Cerebrospinal fluid]] study is not routinely performed because it offers little information, and has high associated risks. It should be analyzed only when [[myelography]] is performed. Approximately 75% of patients whose cerebrospinal fluid is studied demonstrate:
*[[pleocytosis]], ''with either [[polymorphonuclear cells|polymorphonuclear]] or [[mononuclear cells|mononuclear]] predominance.''
*High [[protein]] level
These findings, although suggestive of parameningeal [[infection]], are not specific for the [[epidural space|epidural]] [[infection]]. The gram-stain results of the [[CSF]] are usually negative, being positive only in about 19% of the cases. <ref name="Darouiche2006">{{cite journal|last1=Darouiche|first1=Rabih O.|title=Spinal Epidural Abscess|journal=New England Journal of Medicine|volume=355|issue=19|year=2006|pages=2012–2020|issn=0028-4793|doi=10.1056/NEJMra055111}}</ref><ref name="pmid1359381">{{cite journal| author=Darouiche RO, Hamill RJ, Greenberg SB, Weathers SW, Musher DM| title=Bacterial spinal epidural abscess. Review of 43 cases and literature survey. | journal=Medicine (Baltimore) | year= 1992 | volume= 71 | issue= 6 | pages= 369-85 | pmid=1359381 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1359381  }} </ref> The risks associated with the [[lumbar puncture]] include:
*[[Pleocytosis]], with either [[polymorphonuclear cells|polymorphonuclear]] or [[mononuclear cells|mononuclear]] predominance
*inducing [[meningitis]]


*if the needle transverses the [[epidural abscess]], it may cause a concomitant [[subdural infection]]
These findings, although suggestive of parameningeal [[infection]], are not specific of epidural infection. The Gram-stain results of the cerebrospinal fluid are positive in approximately 19% of cases, while the majority of tests return Gram-negative.<ref name="Darouiche2006">{{cite journal|last1=Darouiche|first1=Rabih O.|title=Spinal Epidural Abscess|journal=New England Journal of Medicine|volume=355|issue=19|year=2006|pages=2012–2020|issn=0028-4793|doi=10.1056/NEJMra055111}}</ref><ref name="pmid1359381">{{cite journal| author=Darouiche RO, Hamill RJ, Greenberg SB, Weathers SW, Musher DM| title=Bacterial spinal epidural abscess. Review of 43 cases and literature survey. | journal=Medicine (Baltimore) | year= 1992 | volume= 71 | issue= 6 | pages= 369-85 | pmid=1359381 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1359381  }} </ref> The risks associated with lumbar puncture include:<ref name="Darouiche2006">{{cite journal|last1=Darouiche|first1=Rabih O.|title=Spinal Epidural Abscess|journal=New England Journal of Medicine|volume=355|issue=19|year=2006|pages=2012–2020|issn=0028-4793|doi=10.1056/NEJMra055111}}</ref><ref name="pmid1359381">{{cite journal| author=Darouiche RO, Hamill RJ, Greenberg SB, Weathers SW, Musher DM| title=Bacterial spinal epidural abscess. Review of 43 cases and literature survey. | journal=Medicine (Baltimore) | year= 1992 | volume= 71 | issue= 6 | pages= 369-85 | pmid=1359381 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1359381  }} </ref><ref name="pmid2385333">{{cite journal| author=Hlavin ML, Kaminski HJ, Ross JS, Ganz E| title=Spinal epidural abscess: a ten-year perspective. | journal=Neurosurgery | year= 1990 | volume= 27 | issue= 2 | pages= 177-84 | pmid=2385333 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2385333  }} </ref>
 
*Inducing [[meningitis]]
*inducing neurologic deterioration in case the [[LP]] is performed below a complete spinal subarachnoid block<ref name="Darouiche2006">{{cite journal|last1=Darouiche|first1=Rabih O.|title=Spinal Epidural Abscess|journal=New England Journal of Medicine|volume=355|issue=19|year=2006|pages=2012–2020|issn=0028-4793|doi=10.1056/NEJMra055111}}</ref><ref name="pmid1359381">{{cite journal| author=Darouiche RO, Hamill RJ, Greenberg SB, Weathers SW, Musher DM| title=Bacterial spinal epidural abscess. Review of 43 cases and literature survey. | journal=Medicine (Baltimore) | year= 1992 | volume= 71 | issue= 6 | pages= 369-85 | pmid=1359381 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1359381  }} </ref><ref name="pmid2385333">{{cite journal| author=Hlavin ML, Kaminski HJ, Ross JS, Ganz E| title=Spinal epidural abscess: a ten-year perspective. | journal=Neurosurgery | year= 1990 | volume= 27 | issue= 2 | pages= 177-84 | pmid=2385333 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2385333  }} </ref>
*[[Subdural infection]] if the needle transverses the epidural abscess
*Inducing neurologic deterioration if lumbar puncture is performed below a complete spinal subarachnoid block


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


[[Category:Wikinfect]]
[[Category:Infectious disease]]
[[Category:Infectious disease]]
[[Category:Disease]]
[[Category:Disease]]
[[Category:Neurology]]
[[Category:Neurology]]
[[Category:Primary care]]
[[Category:Primary care]]

Revision as of 21:01, 16 November 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]; Anthony Gallo, B.S. [3]

Overview

Lumbar puncture is likely not helpful in the diagnosis of epidural abscess.

Other Diagnostic Studies

Lumbar Puncture

Lumbar puncture is likely not helpful in the diagnosis of epidural abscess. Cerebrospinal fluid study is not routinely performed because it offers little information, and has high associated risks. It should be analyzed only when myelography is performed. Approximately 75% of patients whose cerebrospinal fluid is studied demonstrate:

These findings, although suggestive of parameningeal infection, are not specific of epidural infection. The Gram-stain results of the cerebrospinal fluid are positive in approximately 19% of cases, while the majority of tests return Gram-negative.[1][2] The risks associated with lumbar puncture include:[1][2][3]

  • Inducing meningitis
  • Subdural infection if the needle transverses the epidural abscess
  • Inducing neurologic deterioration if lumbar puncture is performed below a complete spinal subarachnoid block

References

  1. 1.0 1.1 Darouiche, Rabih O. (2006). "Spinal Epidural Abscess". New England Journal of Medicine. 355 (19): 2012–2020. doi:10.1056/NEJMra055111. ISSN 0028-4793.
  2. 2.0 2.1 Darouiche RO, Hamill RJ, Greenberg SB, Weathers SW, Musher DM (1992). "Bacterial spinal epidural abscess. Review of 43 cases and literature survey". Medicine (Baltimore). 71 (6): 369–85. PMID 1359381.
  3. Hlavin ML, Kaminski HJ, Ross JS, Ganz E (1990). "Spinal epidural abscess: a ten-year perspective". Neurosurgery. 27 (2): 177–84. PMID 2385333.