Mesoblastic nephroma pathophysiology

Mesoblastic nephroma Microchapters
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Differentiating Mesoblastic nephroma from other Diseases
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Gross Pathology

Characteristic findings of mesoblastic nephroma include:

• solid un-encapsulated mass
• often occurs near the renal hilum
• tends to invade the surrounding structures and renal parenchyma
• Haemorrhage and necrosis are infrequent

Microscopic Pathology

Classic

• Spindle cells in fascicles.
• Infiltrative border.

Cellular

• Plump cells with vesicular nuclei.
• Well-defined border.
• Mitotically active.

Mixed

• both classic pattern and cellular pattern areas are present.

Genetics

t(12:15)(p13;q25) ETV6/NTRK3.