Gestational trophoblastic neoplasia laboratory findings: Difference between revisions

VisualWikitext

Revision as of 15:16, 13 October 2015

Template:Choriocarcinoma

Overview

Increased quantitative beta HCG levels.

Laboratory Findings

Blood tests that may be done include:

Quantitative serum HCG

Human chorionic gonadotropin (HCG or b-HCG) is the most common tumour marker test used to diagnose GTD.
HCG is a hormone that the placenta normally produces during pregnancy.
HCG is a very sensitive test for diagnosing most gestational trophoblastic tumours. HCG is usually measured in the blood, but it can also be measured in the urine.
HCG levels are much higher in women with complete hydatidiform moles and gestational choriocarcinoma compared to HCG levels in women with a normal pregnancy.
With partial moles, the HCG level is higher than normal, but it is not as high as with other types of GTD.
With placental site tumours, the HCG level may be slightly higher than normal, but it is not considered a good marker for this type of tumour.
An HCG test can help find GTD after pregnancy or miscarriage as this hormone should not be present in the blood or urine soon afterward.

Human placental lactogen (hPL)

Human placental lactogen (hPL) is a tumour marker that may be used to follow women with placental site trophoblastic tumours. High hPL levels are found in women with some types of GTD.

Complete blood count- A CBC can check for anemia from long-term (chronic) vaginal bleeding.

Karyotyping

Hydatidiform moles (molar pregnancies) result from abnormal fertilization of an egg by 1 or more sperm, which may result in an abnormal number of chromosomes.

Flow cytometry

Flow cytometry helps determine the types of cells that are present. It also shows if there are an abnormal number of chromosomes, such as in hydatidiform moles.

Immunohistochemistry

Immunohistochemistry helps determine the types of cells that are present, which can be helpful in identifying hydatidiform moles.

Kidney function tests
Liver function tests

References

Template:WH Template:WS

@@ Line 19: / Line 19: @@
 * Human placental lactogen (hPL) is a tumour marker that may be used to follow women with placental site trophoblastic tumours. High hPL levels are found in women with some types of GTD.
 :* [[Complete blood count]]-  A CBC can check for anemia from long-term (chronic) vaginal bleeding.
-Karyotyping
+===Karyotyping===
 Hydatidiform moles (molar pregnancies) result from abnormal fertilization of an egg by 1 or more sperm, which may result in an abnormal number of chromosomes.
+===Flow cytometry===
-Flow cytometry
 Flow cytometry helps determine the types of cells that are present. It also shows if there are an abnormal number of chromosomes, such as in hydatidiform moles.
+===Immunohistochemistry===
-Immunohistochemistry
+Immunohistochemistry helps determine the types of cells that are present, which can be helpful in identifying hydatidiform moles.
-Like flow cytometry, immunohistochemistry (or immunocytochemistry) treats a sample of cells with special antibodiesantibodiesA type of protein made by the immune system that disarms or destroys a specific foreign substance (antigen) when it appears in the body.. Instead of using a laser and computer, chemicals are added that make the cell change colour if a certain antibody attaches to it. The change in colour can only be seen under a microscope. Immunohistochemistry helps determine the types of cells that are present, which can be helpful in identifying hydatidiform moles.
-Read more: http://www.cancer.ca/en/cancer-information/cancer-type/gestational-trophoblastic-disease/diagnosis/?region=ns#ixzz3oScQ9jHR
 :* Kidney function tests
 :*[[Liver function tests]]