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==Overview==
==Overview==
Retinoblastoma must be differentiated from other diseases that cause leucokoria, strabismus, vision problems, eye pain such as cataract, and retinopathy of prematurity.
Retinoblastoma must be differentiated from other diseases that cause leukocoria, such as [differential dx1], [differential dx2], and [differential dx3].


==Differential diagnosis==
==Differential diagnosis==
:1. Persistent hyperplastic primary vitreous (PHPV): congenital developmental anomaly of the eye resulting from failure of the embryological, primary vitreous and hyaloid vasculature to regress, whereby the eye is shorter, develops a cataract, and may present with whitening of the pupil.
The common causes of leukocoria in children include:
:2. [[Coats disease]]: a typically unilateral disease characterised by abnormal development of blood vessels behind the retina, leading to blood vessel abnormalities in the retina and retinal detachment to mimic retinoblastoma.
*Cataract
:3. [[Toxocara canis]]: an infectious disease of the eye associated with exposure to infected puppies, which causes a retinal lesion leading to retinal detachment.
*Persistent fetal vasculature
:4. [[Retinopathy of prematurity]] (ROP): associated with low birth weight infants who receive supplemental oxygen in the period immediately after birth, it involves damage to the retinal tissue and may lead to retinal detachment.
*Coats disease
 
Less common causes of leukocoria include:
If the eye examination is abnormal, further testing may include imaging studies, such as [[computerized tomography]] (CT), [[magnetic resonance imaging]] (MRI), and [[ultrasound]].
*Coloboma (fissure or cleft) of choroid or optic disc
 
*Toxocariasis
*Astrocytic hamartoma
*Retinopathy of prematurity (stage 4, 5)
*Vitreous hemorrhage
*Uveitis (pars planitis)
*Retinal dysplasia
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 20:01, 11 October 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1],Associate Editor(s)-in-Chief: Jyostna Chouturi, M.B.B.S [2]

Overview

Retinoblastoma must be differentiated from other diseases that cause leukocoria, such as [differential dx1], [differential dx2], and [differential dx3].

Differential diagnosis

The common causes of leukocoria in children include:

  • Cataract
  • Persistent fetal vasculature
  • Coats disease

Less common causes of leukocoria include:

  • Coloboma (fissure or cleft) of choroid or optic disc
  • Toxocariasis
  • Astrocytic hamartoma
  • Retinopathy of prematurity (stage 4, 5)
  • Vitreous hemorrhage
  • Uveitis (pars planitis)
  • Retinal dysplasia

References

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