Craniopharyngioma surgery: Difference between revisions

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***'''''Craniotomy''''': When an endonasal approach is not possible, a craniotomy is required. The surgeon often has a limited view of the hypothalamic and sellar regions, and portions of the mass may remain after surgery, accounting for some recurrences. Almost all craniopharyngiomas have an attachment to the pituitary stalk, and of the patients who undergo radical surgery, virtually all will require life-long pituitary hormone replacement with multiple medications.
***'''''Craniotomy''''': When an endonasal approach is not possible, a craniotomy is required. The surgeon often has a limited view of the hypothalamic and sellar regions, and portions of the mass may remain after surgery, accounting for some recurrences. Almost all craniopharyngiomas have an attachment to the pituitary stalk, and of the patients who undergo radical surgery, virtually all will require life-long pituitary hormone replacement with multiple medications.


If the surgeon indicates that the tumor was not completely removed or if post-operative imaging reveals residual craniopharyngioma, radiation therapy may be recommended to prevent early progression. Periodic surveillance using MRI is performed for several years after radical surgery because of the possibility of tumor recurrence.
If the surgeon indicates that the tumor was not completely removed or if post-operative imaging reveals residual craniopharyngioma, '''radiation therapy''' may be recommended to prevent early progression. Periodic surveillance using MRI is performed for several years after radical surgery because of the possibility of tumor recurrence.
*'''Subtotal resection with radiation therapy'''
*'''Subtotal resection with radiation therapy'''
*'''Primary cyst drainage with or without radiation therapy'''
*'''Primary cyst drainage with or without radiation therapy'''

Revision as of 17:01, 23 August 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Patients with craniopharyngioma have many treatment options. The selection depends on the size, location of the tumor. The options are surgery, radiation therapy, chemotherapy, or a combination of these methods. Before treatment starts, ask your health care team about possible side effects and how treatment may change your normal activities. Because these treatments often damage healthy cells and tissues, side effects are common. Side effect may not be the same for each person, and they may change from one treatment session to the next.

Surgery

For treatment purposes, patients are grouped as having newly diagnosed or recurrent disease.[1]

Newly diagnosed craniopharyngioma

There is no consensus on the optimal treatment for newly diagnosed craniopharyngioma, in part because of the lack of prospective randomized trials that compare the different treatment options. Treatment is individualized on the basis of factors that include the following:

  1. Tumor size
  2. Tumor location
  3. Extension of the tumor
  4. Potential short-term and long-term toxicity

Treatment options for newly diagnosed craniopharyngioma include the following:

  • Radical surgery with or without radiation therapy
    • It is possible to remove all visible tumor and achieve long-term disease control because these tumors are histologically benign
    • A 5-year progression-free survival (PFS) rate of about 65% has been reported
    • Radical surgical approaches include the following:
      • Transsphenoidal approach: A transsphenoidal approach may be possible for some small tumors located entirely within the sella. The development of expanded endonasal techniques with endoscopic visualization have allowed this approach to be increasingly used, even for sizeable tumors.
      • Craniotomy: When an endonasal approach is not possible, a craniotomy is required. The surgeon often has a limited view of the hypothalamic and sellar regions, and portions of the mass may remain after surgery, accounting for some recurrences. Almost all craniopharyngiomas have an attachment to the pituitary stalk, and of the patients who undergo radical surgery, virtually all will require life-long pituitary hormone replacement with multiple medications.

If the surgeon indicates that the tumor was not completely removed or if post-operative imaging reveals residual craniopharyngioma, radiation therapy may be recommended to prevent early progression. Periodic surveillance using MRI is performed for several years after radical surgery because of the possibility of tumor recurrence.

  • Subtotal resection with radiation therapy
  • Primary cyst drainage with or without radiation therapy

Recurrent craniopharyngioma

  • Surgery
  • Radiation therapy, including radiosurgery
  • Intracavitary instillation of radioactive P-32, bleomycin, or interferon-alpha, for those with cystic recurrences
  • Systemic interferon

References


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