Brain tumor staging: Difference between revisions
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* Lesions with low proliferative potential, a frequently discrete nature, and the possibility of cure following surgical resection alone | * Lesions with low proliferative potential, a frequently discrete nature, and the possibility of cure following surgical resection alone | ||
* Juvenile pilocytic astrocytoma | **Juvenile pilocytic astrocytoma | ||
**Subependymal giant cell astrocytoma | |||
===Grade II=== | ===Grade II=== | ||
* Lesions that are generally infiltrating and low in mitotic activity but recur; some tumor types tend to progress to higher grades of malignancy | * Lesions that are generally infiltrating and low in mitotic activity but recur; some tumor types tend to progress to higher grades of malignancy | ||
* Diffuse astrocytoma | **Pilomyxoid astrocytoma | ||
**Pleomorphic xanthoastrocytoma | |||
**Diffuse astrocytoma | |||
**Fibrillary astrocytoma | |||
**Protoplasmic astrocytoma | |||
**Gemistocytic astrocytoma | |||
===Grade III=== | ===Grade III=== | ||
* Lesions with histologic evidence of malignancy, generally in the form of mitotic activity, clearly expressed infiltrative capabilities, and anaplasia | * Lesions with histologic evidence of malignancy, generally in the form of mitotic activity, clearly expressed infiltrative capabilities, and anaplasia | ||
* Anaplastic astrocytoma | **Anaplastic astrocytoma | ||
===Grade IV=== | ===Grade IV=== | ||
* Lesions that are mitotically active, necrosis-prone, and generally associated with a rapid preoperative and postoperative evolution of disease | * Lesions that are mitotically active, necrosis-prone, and generally associated with a rapid preoperative and postoperative evolution of disease | ||
* Glioblastoma | **Glioblastoma | ||
**Giant cell glioblastoma | |||
**Gliosarcoma | |||
**Gliomatosis cerebri 9381/3 | |||
==References== | ==References== |
Revision as of 20:25, 21 August 2015
Brain tumor Microchapters |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The subtypes of brain tumors have different staging systems based on the grade, extent of spread, size and presence of distant metastases. According to WHO histologic grading for brain tumors, the grades of brain tumors are subdivided into Grades 1,2,3 and 4. The lower the grade, better the prognosis.
WHO Histologic Grading for CNS Tumors
Grade I
- Lesions with low proliferative potential, a frequently discrete nature, and the possibility of cure following surgical resection alone
- Juvenile pilocytic astrocytoma
- Subependymal giant cell astrocytoma
Grade II
- Lesions that are generally infiltrating and low in mitotic activity but recur; some tumor types tend to progress to higher grades of malignancy
- Pilomyxoid astrocytoma
- Pleomorphic xanthoastrocytoma
- Diffuse astrocytoma
- Fibrillary astrocytoma
- Protoplasmic astrocytoma
- Gemistocytic astrocytoma
Grade III
- Lesions with histologic evidence of malignancy, generally in the form of mitotic activity, clearly expressed infiltrative capabilities, and anaplasia
- Anaplastic astrocytoma
Grade IV
- Lesions that are mitotically active, necrosis-prone, and generally associated with a rapid preoperative and postoperative evolution of disease
- Glioblastoma
- Giant cell glioblastoma
- Gliosarcoma
- Gliomatosis cerebri 9381/3