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===Invasive sinus aspergillosis=== | ===Invasive sinus aspergillosis=== | ||
:*Preferred regimen: [[Voriconazole]] (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h) | |||
:*Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV {{or}} [[Amphotericin B]] lipid complex (ABLC) 5 mg/ kg/day IV {{or}} [[Caspofungin]] (70 mg day 1 IV and 50 mg/day IV thereafter) {{or}} [[Micafungin]] (IV 100–150 mg/day; dose not established ), [[Posaconazole]] (200 mg QID initially, then 400 mg BID PO after stabilization of disease ){{or}} [[Itraconazole]] (dosage depends upon formulation) | |||
===Tracheobronchial aspergillosis=== | ===Tracheobronchial aspergillosis=== | ||
:*Preferred regimen: [[Voriconazole]] (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h) | |||
:*Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV {{or}} [[Amphotericin B]] lipid complex (ABLC) 5 mg/ kg/day IV {{or}} [[Caspofungin]] (70 mg day 1 IV and 50 mg/day IV thereafter) {{or}} [[Micafungin]] (IV 100–150 mg/day; dose not established ), [[Posaconazole]] (200 mg QID initially, then 400 mg BID PO after stabilization of disease ){{or}} [[Itraconazole]] (dosage depends upon formulation) | |||
===Chronic necrotizing pulmonary aspergillosis=== | ===Chronic necrotizing pulmonary aspergillosis=== | ||
:*Preferred regimen: [[Voriconazole]] (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h) | |||
:*Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV {{or}} [[Amphotericin B]] lipid complex (ABLC) 5 mg/ kg/day IV {{or}} [[Caspofungin]] (70 mg day 1 IV and 50 mg/day IV thereafter) {{or}} [[Micafungin]] (IV 100–150 mg/day; dose not established ), [[Posaconazole]] (200 mg QID initially, then 400 mg BID PO after stabilization of disease ){{or}} [[Itraconazole]] (dosage depends upon formulation) | |||
===Aspergillosis of the CNS=== | ===Aspergillosis of the CNS=== | ||
:*Preferred regimen: [[Voriconazole]] (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h) | |||
===Aspergillus infections of the heart (endocarditis, pericarditis, and myocarditis)=== | :*Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV {{or}} [[Amphotericin B]] lipid complex (ABLC) 5 mg/ kg/day IV {{or}} [[Caspofungin]] (70 mg day 1 IV and 50 mg/day IV thereafter) {{or}} [[Micafungin]] (IV 100–150 mg/day; dose not established ), [[Posaconazole]] (200 mg QID initially, then 400 mg BID PO after stabilization of disease ){{or}} [[Itraconazole]] (dosage depends upon formulation)===Aspergillus infections of the heart (endocarditis, pericarditis, and myocarditis)=== | ||
===Aspergillus osteomyelitis and septic arthritis=== | ===Aspergillus osteomyelitis and septic arthritis=== | ||
Revision as of 15:01, 24 June 2015
Aspergillosis
Invasive pulmonary aspergillosis
- Preferred regimen: Voriconazole (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h)
- Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV OR Amphotericin B lipid complex (ABLC) 5 mg/ kg/day IV OR Caspofungin (70 mg day 1 IV and 50 mg/day IV thereafter) OR Micafungin (IV 100–150 mg/day; dose not established ), Posaconazole (200 mg QID initially, then 400 mg BID PO after stabilization of disease )OR Itraconazole (dosage depends upon formulation)
Invasive sinus aspergillosis
- Preferred regimen: Voriconazole (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h)
- Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV OR Amphotericin B lipid complex (ABLC) 5 mg/ kg/day IV OR Caspofungin (70 mg day 1 IV and 50 mg/day IV thereafter) OR Micafungin (IV 100–150 mg/day; dose not established ), Posaconazole (200 mg QID initially, then 400 mg BID PO after stabilization of disease )OR Itraconazole (dosage depends upon formulation)
Tracheobronchial aspergillosis
- Preferred regimen: Voriconazole (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h)
- Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV OR Amphotericin B lipid complex (ABLC) 5 mg/ kg/day IV OR Caspofungin (70 mg day 1 IV and 50 mg/day IV thereafter) OR Micafungin (IV 100–150 mg/day; dose not established ), Posaconazole (200 mg QID initially, then 400 mg BID PO after stabilization of disease )OR Itraconazole (dosage depends upon formulation)
Chronic necrotizing pulmonary aspergillosis
- Preferred regimen: Voriconazole (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h)
- Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV OR Amphotericin B lipid complex (ABLC) 5 mg/ kg/day IV OR Caspofungin (70 mg day 1 IV and 50 mg/day IV thereafter) OR Micafungin (IV 100–150 mg/day; dose not established ), Posaconazole (200 mg QID initially, then 400 mg BID PO after stabilization of disease )OR Itraconazole (dosage depends upon formulation)
Aspergillosis of the CNS
- Preferred regimen: Voriconazole (6 mg/kg IV every 12 h for 1 day, followed by 4 mg/kg IV every 12 h; oral dosage is 200 mg every 12 h)
- Alternative regimen: Liposomal amphotericin B(L-AMB) 3–5 mg/kg/day IV OR Amphotericin B lipid complex (ABLC) 5 mg/ kg/day IV OR Caspofungin (70 mg day 1 IV and 50 mg/day IV thereafter) OR Micafungin (IV 100–150 mg/day; dose not established ), Posaconazole (200 mg QID initially, then 400 mg BID PO after stabilization of disease )OR Itraconazole (dosage depends upon formulation)===Aspergillus infections of the heart (endocarditis, pericarditis, and myocarditis)===