Template:ID-TdP: Difference between revisions

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* Risk categories for antimicrobial agents known to have an association with TdP
===Risk categories for antimicrobial agents known to have an association with TdP {{ID-returntotop}}===
:* '''Drugs with known TdP risk'''
::* [[Azithromycin|Azithromycin (Zithromax®, Zmax®)]]
::* [[Chloroquine|Chloroquine (Aralen®)]]
::* [[Ciprofloxacin|Ciprofloxacin (Cipro®, Cipro-XR®, Neofloxin®)]]
::* [[Clarithromycin|Clarithromycin (Biaxin®, Prevpac®)]]
::* [[Erythromycin|Erythromycin (A/T/S®, Akne-Mycin®, Emgel®, Ery-Tab®, Eryc®, Erycette®, Eryderm®, Erygel®)]]
::* [[Fluconazole|Fluconazole (Diflucan®, Trican®)]]
::* [[Halofantrine|Halofantrine (Halfan®)]]
::* [[Levofloxacin|Levofloxacin (Levaquin®, Tavanic®)]]
::* [[Moxifloxacin|Moxifloxacin (Avelox®, Avalox®, Avelon®)]]
::* [[Pentamidine|Pentamidine (Pentam®)]]
::* [[Sparfloxacin|Sparfloxacin (Zagam®)]]


:* '''Drugs with possible TdP risk'''
* '''Drugs with known TdP risk'''
::* [[Atazanavir|Atazanavir (Reyataz®)]]
:* [[Azithromycin|Azithromycin (Zithromax®, Zmax®)]]
::* [[Bedaquiline|Bedaquiline (Sirturo®)]]
:* [[Chloroquine|Chloroquine (Aralen®)]]
::* [[Dihydroartemisinin-Piperaquine|Dihydroartemisinin-Piperaquine (Eurartesim®)]]
:* [[Ciprofloxacin|Ciprofloxacin (Cipro®, Cipro-XR®, Neofloxin®)]]
::* [[Foscarnet|Foscarnet (Foscavir®)]]
:* [[Clarithromycin|Clarithromycin (Biaxin®, Prevpac®)]]
::* [[Gatifloxacin|Gatifloxacin (Tequin®)]]
:* [[Erythromycin|Erythromycin (A/T/S®, Akne-Mycin®, Emgel®, Ery-Tab®, Eryc®, Erycette®, Eryderm®, Erygel®)]]
::* [[Gemifloxacin|Gemifloxacin (Factive®)]]
:* [[Fluconazole|Fluconazole (Diflucan®, Trican®)]]
::* [[Norfloxacin|Norfloxacin (Noroxin®, Ambigram®)]]
:* [[Halofantrine|Halofantrine (Halfan®)]]
::* [[Ofloxacin|Ofloxacin (Floxin®)]]
:* [[Levofloxacin|Levofloxacin (Levaquin®, Tavanic®)]]
::* [[Rilpivirine|Rilpivirine (Edurant®, Complera®, Eviplera®)]]
:* [[Moxifloxacin|Moxifloxacin (Avelox®, Avalox®, Avelon®)]]
::* [[Roxithromycin|Roxithromycin (Rulide®, Xthrocin®, Roxl-150®, Roxo®, Surlid®, Rulide®, Biaxsig®, Roxar®, Roximycinv®, Roxomycin®, Rulid®, Tirabicin®, Coroxin®)]]
:* [[Pentamidine|Pentamidine (Pentam®)]]
::* [[Saquinavir|Saquinavir (Invirase®(combo))]]
:* [[Sparfloxacin|Sparfloxacin (Zagam®)]]
::* [[Telavancin|Telavancin (Vibativ®)]]
::* [[Telithromycin|Telithromycin (Ketek®)]]


:* '''Drugs with conditional TdP risk'''
* '''Drugs with possible TdP risk'''
::* [[Amantadine|Amantadine (Symmetrel®, Symadine®)]]
:* [[Atazanavir|Atazanavir (Reyataz®)]]
::* [[Hydroxychloroquine|Hydroxychloroquine (Plaquenil®, Quineprox®)]]
:* [[Bedaquiline|Bedaquiline (Sirturo®)]]
::* [[Itraconazole|Itraconazole (Sporanox®, Onmel®)]]
:* [[Dihydroartemisinin-Piperaquine|Dihydroartemisinin-Piperaquine (Eurartesim®)]]
::* [[Ketoconazole|Ketoconazole (Nizoral®, Sebizole®, Ketomed®, Keton®)]]
:* [[Foscarnet|Foscarnet (Foscavir®)]]
::* [[Metronidazole|Metronidazole (Flagyl® and many others)]]
:* [[Gatifloxacin|Gatifloxacin (Tequin®)]]
::* [[Nelfinavir|Nelfinavir (Viracept®)]]
:* [[Gemifloxacin|Gemifloxacin (Factive®)]]
::* [[Posaconazole|Posaconazole (Noxafil®, Posamol®)]]
:* [[Norfloxacin|Norfloxacin (Noroxin®, Ambigram®)]]
::* [[Quinine sulfate|Quinine sulfate (Qualaquin®)]]
:* [[Ofloxacin|Ofloxacin (Floxin®)]]
::* [[Ritonavir|Ritonavir (Norvir®)]]
:* [[Rilpivirine|Rilpivirine (Edurant®, Complera®, Eviplera®)]]
::* [[Telaprevir|Telaprevir (Incivek®, Incivo®)]]
:* [[Roxithromycin|Roxithromycin (Rulide®, Xthrocin®, Roxl-150®, Roxo®, Surlid®, Rulide®, Biaxsig®, Roxar®, Roximycinv®, Roxomycin®, Rulid®, Tirabicin®, Coroxin®)]]
::* [[Voriconazole|Voriconazole (VFend®)]]
:* [[Saquinavir|Saquinavir (Invirase®(combo))]]
:* [[Telavancin|Telavancin (Vibativ®)]]
:* [[Telithromycin|Telithromycin (Ketek®)]]


:* '''Drugs to be avoided by congenital Long QT'''
* '''Drugs with conditional TdP risk'''
::* [[Trimethoprim-Sulfamethoxazole|Trimethoprim-Sulfamethoxazole (Septra®, Bactrim®, Sulfatrim®, Biseptol®, Co-trimoxazole®, Cotrim®, Septrin®, Trisul®)]]
:* [[Amantadine|Amantadine (Symmetrel®, Symadine®)]]
:* [[Hydroxychloroquine|Hydroxychloroquine (Plaquenil®, Quineprox®)]]
:* [[Itraconazole|Itraconazole (Sporanox®, Onmel®)]]
:* [[Ketoconazole|Ketoconazole (Nizoral®, Sebizole®, Ketomed®, Keton®)]]
:* [[Metronidazole|Metronidazole (Flagyl® and many others)]]
:* [[Nelfinavir|Nelfinavir (Viracept®)]]
:* [[Posaconazole|Posaconazole (Noxafil®, Posamol®)]]
:* [[Quinine sulfate|Quinine sulfate (Qualaquin®)]]
:* [[Ritonavir|Ritonavir (Norvir®)]]
:* [[Telaprevir|Telaprevir (Incivek®, Incivo®)]]
:* [[Voriconazole|Voriconazole (VFend®)]]


* Torsades de pointes risk stratification schedules for antimicrobial agents
* '''Drugs to be avoided by congenital Long QT'''
:* '''Schedule I (Highest TdP risk, potent IKr blockers, TdP risk >1%)'''
:* [[Trimethoprim-Sulfamethoxazole|Trimethoprim-Sulfamethoxazole (Septra®, Bactrim®, Sulfatrim®, Biseptol®, Co-trimoxazole®, Cotrim®, Septrin®, Trisul®)]]
::* Not available


:* '''Schedule II (Significant risk for TdP, particularly when coadministered with CYP inhibitors, relatively potent IKr blockade)'''
===Torsades de pointes risk stratification schedules for antimicrobial agents {{ID-returntotop}}===
::* Not available
* '''Schedule I (Highest TdP risk, potent IKr blockers, TdP risk >1%)'''
:* Not available


:* '''Schedule III (Risk for TdP is described, IKr blockade, particularly when coadministered with CYP inhibitors)'''
* '''Schedule II (Significant risk for TdP, particularly when coadministered with CYP inhibitors, relatively potent IKr blockade)'''
::* [[Clarithromycin|Clarithromycin (Biaxin®, Prevpac®)]]
:* Not available
::* [[Erythromycin|Erythromycin (A/T/S®, Akne-Mycin®, Emgel®, Ery-Tab®, Eryc®, Erycette®, Eryderm®, Erygel®)]]
::* [[Itraconazole|Itraconazole (Sporanox®, Onmel®)]]
::* [[Ketoconazole|Ketoconazole (Nizoral®, Sebizole®, Ketomed®, Keton®)]]
::* [[Pentamidine|Pentamidine (Pentam®)]]
::* [[Sparfloxacin|Sparfloxacin (Zagam®)]]


:* '''Schedule IV (Minimal risk for TdP, case reports of TdP, mild IKr blockade, may have CYP interactions)'''
* '''Schedule III (Risk for TdP is described, IKr blockade, particularly when coadministered with CYP inhibitors)'''
::* [[Fluconazole|Fluconazole (Diflucan®, Trican®)]]
:* [[Clarithromycin|Clarithromycin (Biaxin®, Prevpac®)]]
::* [[Gatifloxacin|Gatifloxacin (Tequin®)]]
:* [[Erythromycin|Erythromycin (A/T/S®, Akne-Mycin®, Emgel®, Ery-Tab®, Eryc®, Erycette®, Eryderm®, Erygel®)]]
::* [[Gemifloxacin|Gemifloxacin (Factive®)]]
:* [[Itraconazole|Itraconazole (Sporanox®, Onmel®)]]
::* [[Levofloxacin|Levofloxacin (Levaquin®, Tavanic®)]]
:* [[Ketoconazole|Ketoconazole (Nizoral®, Sebizole®, Ketomed®, Keton®)]]
::* [[Moxifloxacin|Moxifloxacin (Avelox®, Avalox®, Avelon®)]]
:* [[Pentamidine|Pentamidine (Pentam®)]]
::* [[Telithromycin|Telithromycin (Ketek®)]]
:* [[Sparfloxacin|Sparfloxacin (Zagam®)]]
::* [[Voriconazole|Voriconazole (VFend®)]]


:* '''Schedule V (Questionable or minimal risk for QT interval prolongation or TdP)'''
* '''Schedule IV (Minimal risk for TdP, case reports of TdP, mild IKr blockade, may have CYP interactions)'''
::* [[Azithromycin|Azithromycin (Zithromax®, Zmax®)]]
:* [[Fluconazole|Fluconazole (Diflucan®, Trican®)]]
::* [[Ciprofloxacin|Ciprofloxacin (Cipro®, Cipro-XR®, Neofloxin®)]]
:* [[Gatifloxacin|Gatifloxacin (Tequin®)]]
::* [[Trimethoprim-Sulfamethoxazole|Trimethoprim-Sulfamethoxazole (Septra®, Bactrim®, Sulfatrim®, Biseptol®, Co-trimoxazole®, Cotrim®, Septrin®, Trisul®)]]
:* [[Gemifloxacin|Gemifloxacin (Factive®)]]
:* [[Levofloxacin|Levofloxacin (Levaquin®, Tavanic®)]]
:* [[Moxifloxacin|Moxifloxacin (Avelox®, Avalox®, Avelon®)]]
:* [[Telithromycin|Telithromycin (Ketek®)]]
:* [[Voriconazole|Voriconazole (VFend®)]]
 
* '''Schedule V (Questionable or minimal risk for QT interval prolongation or TdP)'''
:* [[Azithromycin|Azithromycin (Zithromax®, Zmax®)]]
:* [[Ciprofloxacin|Ciprofloxacin (Cipro®, Cipro-XR®, Neofloxin®)]]
:* [[Trimethoprim-Sulfamethoxazole|Trimethoprim-Sulfamethoxazole (Septra®, Bactrim®, Sulfatrim®, Biseptol®, Co-trimoxazole®, Cotrim®, Septrin®, Trisul®)]]

Revision as of 22:07, 31 May 2015

Risk categories for antimicrobial agents known to have an association with TdP Return to Top

  • Drugs with known TdP risk
  • Drugs with possible TdP risk
  • Drugs with conditional TdP risk
  • Drugs to be avoided by congenital Long QT

Torsades de pointes risk stratification schedules for antimicrobial agents Return to Top

  • Schedule I (Highest TdP risk, potent IKr blockers, TdP risk >1%)
  • Not available
  • Schedule II (Significant risk for TdP, particularly when coadministered with CYP inhibitors, relatively potent IKr blockade)
  • Not available
  • Schedule III (Risk for TdP is described, IKr blockade, particularly when coadministered with CYP inhibitors)
  • Schedule IV (Minimal risk for TdP, case reports of TdP, mild IKr blockade, may have CYP interactions)
  • Schedule V (Questionable or minimal risk for QT interval prolongation or TdP)
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