Tolbutamide

Tolbutamide
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Disclaimer

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Overview

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Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

There is limited information regarding Tolbutamide FDA-Labeled Indications and Dosage (Adult) in the drug label.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Tolbutamide in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Tolbutamide in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding Tolbutamide FDA-Labeled Indications and Dosage (Pediatric) in the drug label.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Tolbutamide in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Tolbutamide in pediatric patients.

Contraindications

There is limited information regarding Tolbutamide Contraindications in the drug label.

Warnings

There is limited information regarding Tolbutamide Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Tolbutamide Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Tolbutamide Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Tolbutamide Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Tolbutamide in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Tolbutamide in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Tolbutamide during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Tolbutamide in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Tolbutamide in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Tolbutamide in geriatric settings.

Gender

There is no FDA guidance on the use of Tolbutamide with respect to specific gender populations.

Race

There is no FDA guidance on the use of Tolbutamide with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Tolbutamide in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Tolbutamide in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Tolbutamide in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Tolbutamide in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Tolbutamide Administration in the drug label.

Monitoring

There is limited information regarding Tolbutamide Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Tolbutamide and IV administrations.

Overdosage

There is limited information regarding Tolbutamide overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Tolbutamide Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Tolbutamide Mechanism of Action in the drug label.

Structure

There is limited information regarding Tolbutamide Structure in the drug label.

Pharmacodynamics

There is limited information regarding Tolbutamide Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Tolbutamide Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Tolbutamide Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Tolbutamide Clinical Studies in the drug label.

How Supplied

There is limited information regarding Tolbutamide How Supplied in the drug label.

Storage

There is limited information regarding Tolbutamide Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Tolbutamide Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Tolbutamide interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Tolbutamide Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Tolbutamide Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

Tolbutamide

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Clinical data
[[Regulation of therapeutic goods |Template:Engvar data]]	US FDA: Tolbutamide
Pregnancy category	AU: C US: C (Risk not ruled out)
Routes of administration	Oral (tablet)
ATC code	A10BB03 (WHO) V04CA01 (WHO)
Legal status
Legal status	UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Protein binding	96%
Metabolism	Hepatic (CYP2C19-mediated)
Elimination half-life	4.5 to 6.5 hours
Excretion	Renal
Identifiers
IUPAC name 3-butyl-1-(4-methylphenyl)sulfonyl-urea
CAS Number	64-77-7
PubChem CID	5505
DrugBank	APRD00267
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C12H18N2O3S
Molar mass	270.349 g/mol

WikiDoc Resources for Tolbutamide
Articles
Most recent articles on Tolbutamide Most cited articles on Tolbutamide Review articles on Tolbutamide Articles on Tolbutamide in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Tolbutamide Images of Tolbutamide Photos of Tolbutamide Podcasts & MP3s on Tolbutamide Videos on Tolbutamide
Evidence Based Medicine
Cochrane Collaboration on Tolbutamide Bandolier on Tolbutamide TRIP on Tolbutamide
Clinical Trials
Ongoing Trials on Tolbutamide at Clinical Trials.gov Trial results on Tolbutamide Clinical Trials on Tolbutamide at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Tolbutamide NICE Guidance on Tolbutamide NHS PRODIGY Guidance FDA on Tolbutamide CDC on Tolbutamide
Books
Books on Tolbutamide
News
Tolbutamide in the news Be alerted to news on Tolbutamide News trends on Tolbutamide
Commentary
Blogs on Tolbutamide
Definitions
Definitions of Tolbutamide
Patient Resources / Community
Patient resources on Tolbutamide Discussion groups on Tolbutamide Patient Handouts on Tolbutamide Directions to Hospitals Treating Tolbutamide Risk calculators and risk factors for Tolbutamide
Healthcare Provider Resources
Symptoms of Tolbutamide Causes & Risk Factors for Tolbutamide Diagnostic studies for Tolbutamide Treatment of Tolbutamide
Continuing Medical Education (CME)
CME Programs on Tolbutamide
International
Tolbutamide en Espanol Tolbutamide en Francais
Business
Tolbutamide in the Marketplace Patents on Tolbutamide
Experimental / Informatics
List of terms related to Tolbutamide

For patient information, click here

Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug sold under the brand name Orinase. This drug may be used in the management of type II diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas. Since the pancreas must synthesize insulin in order for this drug to work, it is not effective in the management of type I diabetes. It is not routinely used due to a higher incidence of adverse effects compared to newer second generation sulfonylureas, such as glyburide.

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