Hyperlipoproteinemia natural history, complications and prognosis: Difference between revisions
Hardik Patel (talk | contribs) |
Hardik Patel (talk | contribs) |
||
| Line 7: | Line 7: | ||
==Natural History== | ==Natural History== | ||
Hyperlipidemia may be inherited or secondary to some underlying disorder. High levels of LDL-cholesterol in hyperlipidemia increase cholesterol uptake in non-hepatic cells where monocytes and macrophages engulf cholesterol particles, leading to formation of foam cells and atherosclerotic plaque in the [[endothelium]] of arteries, leading to development of symptoms of [[coronary artery disease]] or [[cerebrovascular disease]]. Cholesterol also accumulates in other areas, such as the skin, causing [[xanthelasma]]s and the tendons, causing variety of [[xanthoma]]s. Early corneal arcus is also common. Without treatment, the patient will also develop valvular abnormalities, most frequently aortic stenosis, due to the deposition of cholesterol. | Hyperlipidemia may be inherited or secondary to some underlying disorder. High levels of LDL-cholesterol in hyperlipidemia increase cholesterol uptake in non-hepatic cells where monocytes and macrophages engulf cholesterol particles, leading to formation of foam cells and atherosclerotic plaque in the [[endothelium]] of arteries, leading to development of symptoms of [[coronary artery disease]] or [[cerebrovascular disease]]. Cholesterol also accumulates in other areas, such as the skin, causing [[xanthelasma]]s and the tendons, causing variety of [[xanthoma]]s. Early corneal arcus is also common. Without treatment, the patient will also develop valvular abnormalities, most frequently [[aortic stenosis]], due to the deposition of cholesterol. | ||
==Complications== | ==Complications== | ||
Revision as of 16:35, 23 October 2012
|
Lipoprotein Disorders Microchapters |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
"(Disease name), without treatment, progresses to eventually cause _____ and ____. (Disease name) can be complicated by the development of ____. The prognosis of (disease name) is poor/ good. (Disease name) is associated with a 1/5/10 year mortality of ___%.
Natural History
Hyperlipidemia may be inherited or secondary to some underlying disorder. High levels of LDL-cholesterol in hyperlipidemia increase cholesterol uptake in non-hepatic cells where monocytes and macrophages engulf cholesterol particles, leading to formation of foam cells and atherosclerotic plaque in the endothelium of arteries, leading to development of symptoms of coronary artery disease or cerebrovascular disease. Cholesterol also accumulates in other areas, such as the skin, causing xanthelasmas and the tendons, causing variety of xanthomas. Early corneal arcus is also common. Without treatment, the patient will also develop valvular abnormalities, most frequently aortic stenosis, due to the deposition of cholesterol.
Complications
- Using lists can be helpful for describing this section.
- You can use these template sentences;
- "Complications that can develop as a result of (disease name) are ___ (describe in list form)".
- "Complications that can develop as a result of the treatment of (disease name) are ___ (describe in list form).
- Next to each complication, provide a brief one sentence description detailing the complication.
- For an example of the complications section in a natural history, complications and prognosis page, click here.
Prognosis
- This section should detail the prognosis of the disease, both treated and untreated.
- Here are some template sentences; "The prognosis of (disease name) is poor/good with treatment. Without treatment, (disease name) will result in ___. (Disease name) is associated with a 1/5/10 year mortality of __. The presence of ___ is associated with a particularly poor prognosis among patients with (disease name).
- For an example of a prognosis section within a natural history, complications and prognosis page, click here.