MTMR6: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Myotubularin-related protein 6''' is a [[protein]] that in humans is encoded by the ''MTMR6'' [[gene]].<ref name="pmid9736772">{{cite journal | vauthors = Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL | title = Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human | journal = Hum. Mol. Genet. | volume = 7 | issue = 11 | pages = 1703–12  | date = Dec 1998 | pmid = 9736772 | pmc =  | doi = 10.1093/hmg/7.11.1703 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MTMR6 myotubularin related protein 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9107| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Myotubularin related protein 6
| HGNCid = 7453
| Symbol = MTMR6
| AltSymbols =;
| OMIM = 603561
| ECnumber = 
| Homologene = 55842
| MGIid = 2145637
| GeneAtlas_image1 = PBB_GE_MTMR6_214429_at_tn.png
| Function = {{GNF_GO|id=GO:0004437 |text = inositol or phosphatidylinositol phosphatase activity}} {{GNF_GO|id=GO:0004722 |text = protein serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0046839 |text = phospholipid dephosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9107
    | Hs_Ensembl = ENSG00000139505
    | Hs_RefseqProtein = NP_004676
    | Hs_RefseqmRNA = NM_004685
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 24718339
    | Hs_GenLoc_end = 24760147
    | Hs_Uniprot = Q9Y217
    | Mm_EntrezGene = 219135
    | Mm_Ensembl = ENSMUSG00000021987
    | Mm_RefseqmRNA = NM_144843
    | Mm_RefseqProtein = NP_659092
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 59219338
    | Mm_GenLoc_end = 59256480
    | Mm_Uniprot = 
  }}
}}
'''Myotubularin related protein 6''', also known as '''MTMR6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MTMR6 myotubularin related protein 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9107| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
MTMR6 has been shown to [[Protein-protein interaction|interact]] with [[MTMR9]].<ref name=pmid12890864>{{cite journal | vauthors = Mochizuki Y, Majerus PW | title = Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 17 | pages = 9768–73 | date = Aug 2003 | pmid = 12890864 | pmc = 187840 | doi = 10.1073/pnas.1333958100 }}</ref>
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| summary_text =  
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==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
| citations =
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Laporte J, Blondeau F, Buj-Bello A, ''et al.'' |title=Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. |journal=Hum. Mol. Genet. |volume=7 |issue= 11 |pages= 1703-12 |year= 1998 |pmid= 9736772 |doi=  }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Rep. | volume = 1 | issue = 3 | pages = 287–92 | year = 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Schaletzky J, Dove SK, Short B, Lorenzo O, Clague MJ, Barr FA | title = Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases | journal = Curr. Biol. | volume = 13 | issue = 6 | pages = 504–9 | year = 2003 | pmid = 12646134 | doi = 10.1016/S0960-9822(03)00132-5 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, Mitchell CA | title = Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 15 | pages = 8660–5 | year = 2003 | pmid = 12847286 | pmc = 166368 | doi = 10.1073/pnas.1033097100 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Mochizuki Y, Majerus PW | title = Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 17 | pages = 9768–73 | year = 2003 | pmid = 12890864 | pmc = 187840 | doi = 10.1073/pnas.1333958100 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Res. | volume = 14 | issue = 10B | pages = 2136–44 | year = 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal  | author=Schaletzky J, Dove SK, Short B, ''et al.'' |title=Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases. |journal=Curr. Biol. |volume=13 |issue= 6 |pages= 504-9 |year= 2004 |pmid= 12646134 |doi= }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Res. | volume = 34 | issue = Database issue | pages = D415-8 | year = 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal | author=Nandurkar HH, Layton M, Laporte J, ''et al.'' |title=Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 15 |pages= 8660-5 |year= 2003 |pmid= 12847286 |doi= 10.1073/pnas.1033097100 }}
* {{cite journal | vauthors = Srivastava S, Ko K, Choudhury P, Li Z, Johnson AK, Nadkarni V, Unutmaz D, Coetzee WA, Skolnik EY | title = Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells | journal = Mol. Cell. Biol. | volume = 26 | issue = 15 | pages = 5595–602 | year = 2006 | pmid = 16847315 | pmc = 1592754 | doi = 10.1128/MCB.00352-06 }}
*{{cite journal | author=Mochizuki Y, Majerus PW |title=Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 17 |pages= 9768-73 |year= 2003 |pmid= 12890864 |doi= 10.1073/pnas.1333958100 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Dunham A, Matthews LH, Burton J, ''et al.'' |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522-8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Srivastava S, Ko K, Choudhury P, ''et al.'' |title=Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells. |journal=Mol. Cell. Biol. |volume=26 |issue= 15 |pages= 5595-602 |year= 2006 |pmid= 16847315 |doi= 10.1128/MCB.00352-06 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Protein tyrosine phosphatases}}
{{WikiDoc Sources}}
 
 
{{gene-13-stub}}

Latest revision as of 07:02, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Myotubularin-related protein 6 is a protein that in humans is encoded by the MTMR6 gene.[1][2]

Interactions

MTMR6 has been shown to interact with MTMR9.[3]

References

  1. ↑ Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL (Dec 1998). "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human". Hum. Mol. Genet. 7 (11): 1703–12. doi:10.1093/hmg/7.11.1703. PMID 9736772.
  2. ↑ "Entrez Gene: MTMR6 myotubularin related protein 6".
  3. ↑ Mochizuki Y, Majerus PW (Aug 2003). "Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9768–73. doi:10.1073/pnas.1333958100. PMC 187840. PMID 12890864.

Further reading


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