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* [[Transmissible spongiform encephalopathy]] - A collection of diseases all caused by prions, and characterized by "spongy" brain tissue (riddled with holes), impaired locomotion or coordination, and a high fatality rate. Includes [[bovine spongiform encephalopathy]] (mad cow disease), [[scrapie]], and [[Kuru (disease)|kuru]] among others.
* [[Transmissible spongiform encephalopathy]] - A collection of diseases all caused by prions, and characterized by "spongy" brain tissue (riddled with holes), impaired locomotion or coordination, and a high fatality rate. Includes [[bovine spongiform encephalopathy]] (mad cow disease), [[scrapie]], and [[Kuru (disease)|kuru]] among others.


==Differential diagnosis of causes of encephalopathy==
==Causes==
Encephalopathy alters brain function and/or structure. It may be caused by an infectious agent ([[bacterium|bacteria]], [[virus]], or [[prion]]), [[metabolism|metabolic]] or [[mitochondrion|mitochondrial]] dysfunction, [[brain tumor]] or increased [[intracranial pressure]], prolonged exposure to toxins (including solvents, drugs, [[alcohol]], paints, industrial chemicals, and certain metals), radiation, chronic progressive trauma, poor nutrition, or lack of [[oxygen]] or blood flow to the brain. It is also known that concomitant use of [[lithium]] with other neuroleptics may, in rare cases, cause encephalopathy.
Encephalopathy alters brain function and/or structure.It may be caused by an infectious agent ([[bacterium|bacteria]], [[virus]], or [[prion]]), [[metabolism|metabolic]] or [[mitochondrion|mitochondrial]] dysfunction, [[brain tumor]] or increased [[intracranial pressure]], prolonged exposure to toxins (including solvents, drugs, [[alcohol]], paints, industrial chemicals, and certain metals), radiation, chronic progressive trauma, poor nutrition, or lack of [[oxygen]] or blood flow to the brain. It is also known that concomitant use of [[lithium]] with other neuroleptics may, in rare cases, cause encephalopathy.


==Signs and symptoms==
==Signs and symptoms==

Revision as of 00:21, 19 July 2012

Encephalopathy
Binswangers Subcortical Encephalopathy: Gross fixed tissue horizontal section cerebral hemispheres at level of genu internal capsule
Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology
MeSH D001927

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Encephalopathy literally means disease of the brain. It is a brain malfunction in the face of systemic metabolic derangements due to cardiopulmonary, mitochondrial, renal, hepatic or endocrine disease. In medical jargon it can refer to a wide variety of degenerative brain disorders with very different etiologies, prognoses and implications. For example, prion diseases, all of which cause transmissible spongiform encephalopathies, are nearly always fatal and have an infectious origin, but other encephalopathies are reversible and can be caused by deficiency, toxins, and several other causes.

Types

There are many types of encephalopathy. Some examples include:

Causes

Encephalopathy alters brain function and/or structure.It may be caused by an infectious agent (bacteria, virus, or prion), metabolic or mitochondrial dysfunction, brain tumor or increased intracranial pressure, prolonged exposure to toxins (including solvents, drugs, alcohol, paints, industrial chemicals, and certain metals), radiation, chronic progressive trauma, poor nutrition, or lack of oxygen or blood flow to the brain. It is also known that concomitant use of lithium with other neuroleptics may, in rare cases, cause encephalopathy.

Signs and symptoms

The hallmark of encephalopathy is an altered mental state. Depending on the type and severity of encephalopathy, common neurological symptoms are progressive loss of memory and cognitive ability, subtle personality changes, inability to concentrate, lethargy, and progressive loss of consciousness. Other neurological symptoms may include myoclonus (involuntary twitching of a muscle or group of muscles), nystagmus (rapid, involuntary eye movement), tremor, muscle atrophy and weakness, dementia, seizures, and loss of ability to swallow or speak.

Diagnosis

Blood tests, spinal fluid examination by lumbar puncture, imaging studies, electroencephalography.

Therapy

Treatment is symptomatic and varies, according to the type and severity of the encephalopathy. Anticonvulsants may be prescribed to reduce or halt any seizures. Changes to diet and nutritional supplements may help some patients. In severe cases, dialysis or organ replacement surgery may be needed.

Prognosis

Treating the underlying cause of the disorder may improve or reverse symptoms. However, in some cases, the encephalopathy may cause permanent structural changes and irreversible damage to the brain. Some encephalopathies can be fatal.

References

The Diagnosis of Stupor and Coma by Plum and Posner ISBN 0195138988 remains one the of best detailed observational references to the condition

See also

Template:CNS diseases of the nervous system Template:SIB

de:Enzephalopathie id:Ensefalopati it:Encefalopatia nl:Encefalopathie


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