Neurofibroma classification: Difference between revisions
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* Deep | * Deep | ||
* Associated with [[NF1]] | * Associated with [[NF1]] | ||
* Diffuse involvement along a large nerve and its branches | * [[Diffuse]] involvement along a large [[nerve]] and its [[Branches of medicine|branches]] | ||
* Mostly internal/ intraneural | * Mostly [[internal]]/ intraneural | ||
* Can also involve small nerves and superficial skin | * Can also involve small [[nerves]] and [[superficial]] [[skin]] | ||
* Have more [[connective tissue]]/extracellular matrix than cutaneous [[Neurofibroma|neurofibromas]], that separates the [[nerve fibers]] | * Have more [[connective tissue]]/[[extracellular matrix]] than [[cutaneous]] [[Neurofibroma|neurofibromas]], that separates the [[nerve fibers]] | ||
* Gross enlargement of the nerve with nodular tumor development results in the gross pathologic appearance referred to as “bag of worms” | * [[Gross]] enlargement of the [[nerve]] with [[nodular]] [[tumor]] [[development]] results in the [[gross]] [[Pathological|pathologic]] [[appearance]] referred to as “bag of worms” | ||
* Generally believed to be present at [[birth]] (congenital) | * Generally believed to be present at [[birth]] ([[congenital]]) | ||
* Disfiguring | * Disfiguring | ||
* Affects function due to sheer size as well as neurovascular compromise | * Affects [[Function (biology)|function]] due to sheer size as well as [[Neurovascular bundle|neurovascular]] compromise | ||
* Upto 5% risk of malignant transformation | * Upto 5% risk of [[malignant]] [[transformation]] | ||
*Plexiform neurofibroma exhibits following features on T2-weighted MRI: | *[[Plexiform neurofibroma]] exhibits following [[Features (pattern recognition)|features]] on T2-weighted [[Magnetic resonance imaging|MRI]]: | ||
**Target sign (low signal intensity centrally with a ring of high signal intensity peripherally) | **Target [[Sign (medicine)|sign]] (low [[Signal (biology)|signal]] [[intensity]] centrally with a ring of high [[Signal (biology)|signal]] [[intensity]] peripherally) | ||
**Fascicular sign | **Fascicular [[Sign (medical)|sign]] | ||
**May appear as a larger and more infiltrating mass with lobulated borders with inhomogeneous enhancement | **May [[Appearance|appear]] as a larger and more [[Infiltration (medical)|infiltrating]] [[mass]] with lobulated borders with inhomogeneous enhancement | ||
|- | |- | ||
| style="background:#DCDCDC;" align="center" + |'''[[Pigmented lesions|Pigmented]] [[neurofibroma]]''' | | style="background:#DCDCDC;" align="center" + |'''[[Pigmented lesions|Pigmented]] [[neurofibroma]]''' | ||
| | | | ||
* Neurofibroma with melanin-bearing pigmented cells, usually only appreciated microscopically | * [[Neurofibroma]] with [[melanin]]-bearing [[Pigmented Lesions|pigmented]] [[Cells (biology)|cells]], usually only appreciated [[Microscopic|microscopically]] | ||
* Not considered a true subtype | * Not considered a true subtype | ||
* No increased risk of | * No increased risk of [[Malignancy|malignan]]<nowiki/>t [[transformation]] | ||
|} | |} | ||
Revision as of 18:37, 27 April 2019
Neurofibroma Microchapters |
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Neurofibroma classification On the Web |
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Risk calculators and risk factors for Neurofibroma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]
Overview
Neurofibroma may be classified into 5 subtypes: cutaneous/dermal/localized, localized intraneural, subcutaneous, diffuse, intramuscular, plexiform and pigmented neurofibroma. Plexiform neurofibromas may be further sub-classified into diffuse and nodular plexiform.
Classification
Neurofibroma may be classified into following subtypes:[1][2][3][4]
Types of neurofibromas | Characteristics/Description |
---|---|
Cutaneous/Dermal/Localized/Sporadic neurofibroma (90%) |
|
Localized Intraneural neurofibroma | |
Subcutaneous neurofibroma |
|
Diffuse neurofibroma |
|
Intramuscular neurofibroma | |
Plexiform neurofibroma
(deep) |
|
Pigmented neurofibroma |
|
Plexiform neurofibromas can be further subclassified into following:[5]
Types of neurofibromas | Characteristics/Description |
---|---|
Diffuse Plexiform neurofibroma | |
Nodular Plexiform neurofibroma |
|
References
- ↑ Neurofibroma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Neurofibroma#cite_note-pmid15486243-2 Accessed on November 17, 2015
- ↑ http://www.nfmidwest.org/wp-content/uploads/2016/03/Neurofibromas.pdf
- ↑ https://pubs.rsna.org/doi/10.1148/rg.24si035170#REF8
- ↑ http://surgpathcriteria.stanford.edu/peripheral-nerve/neurofibroma/
- ↑ http://www.nfmidwest.org/wp-content/uploads/2016/03/Neurofibromas.pdf