Neurofibroma MRI: Difference between revisions

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* Hyperintense
* Hyperintense
* Homogeneous high signal intensity (higher than fat)  
* Homogeneous high signal intensity (higher than fat)  
* Target sign (low signal intensity centrally with a ring of high signal intensity peripherally) in case of plexiform neurofibromas
* Target sign (plexiform neurofibromas)
** Low signal intensity centrally with a ring of high signal intensity peripherally
** Due to a dense central area of collagenous stroma
** Highly suggestive of neurofibroma but occasionally also seen in schwannomas and malignant peripheral nerve sheath tumors
* Fascicular sign
* Plexiform neurofibromas may appear as a larger and more infiltrating mass with lobulated borders with inhomogeneous enhancement  
* Plexiform neurofibromas may appear as a larger and more infiltrating mass with lobulated borders with inhomogeneous enhancement  
* Myxoid stroma enhancement helps differentiating the high signal intensity at T2-weighted imaging from cystic change or necrosis  
* Myxoid stroma enhancement helps differentiating the high signal intensity at T2-weighted imaging from cystic change or necrosis  
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|-
|'''T1 with gadolinium contrast'''
|'''T1 C+ (Gd) (with gadolinium contrast)'''
|
|
* Heterogenous enhancement
* Heterogenous enhancement

Revision as of 17:44, 26 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Shanshan Cen, M.D. [3]

Overview

MRI may be helpful in the diagnosis of neurofibroma.

MRI

  • MRI may be helpful in the diagnosis of neurofibroma
  • MRI signal characteristics include:[1]
MRI sequence Characteristics
T1
  • Hypointense
  • Homogeneous low signal intensity
  • Center demonstrating a higher signal intensity than the periphery (reverse of target sign on T2)
T2
  • Hyperintense
  • Homogeneous high signal intensity (higher than fat)
  • Target sign (plexiform neurofibromas)
    • Low signal intensity centrally with a ring of high signal intensity peripherally
    • Due to a dense central area of collagenous stroma
    • Highly suggestive of neurofibroma but occasionally also seen in schwannomas and malignant peripheral nerve sheath tumors
  • Fascicular sign
  • Plexiform neurofibromas may appear as a larger and more infiltrating mass with lobulated borders with inhomogeneous enhancement
  • Myxoid stroma enhancement helps differentiating the high signal intensity at T2-weighted imaging from cystic change or necrosis
T1 C+ (Gd) (with gadolinium contrast)
  • Heterogenous enhancement

References

  1. Neurofibroma.Dr Bruno Di Muzio and Dr Maxime St-Amant et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/neurofibroma Accessed on November 17, 2015


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