Glanzmann's thrombasthenia risk factors: Difference between revisions
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==Risk Factors== | ==Risk Factors== | ||
Common risk factors that increase [[autoantibodies]] production in [[acquired]] [[Glanzmann's thrombasthenia|Glanzmann thrombasthenia]] include: | Common risk factors that increase [[autoantibodies]] production in [[acquired]] [[Glanzmann's thrombasthenia|Glanzmann thrombasthenia]] include: | ||
* [[Hematologic disorders]] and [[malignancies]], such as : | * [[Hematologic disorders]] and [[malignancies]], such as :<ref name="pmid16722529">{{cite journal |vauthors=Nurden AT |title=Glanzmann thrombasthenia |journal=Orphanet J Rare Dis |volume=1 |issue= |pages=10 |date=April 2006 |pmid=16722529 |pmc=1475837 |doi=10.1186/1750-1172-1-10 |url=}}</ref> | ||
# [[Acute lymphoblastic leukemia]] | # [[Acute lymphoblastic leukemia]] | ||
# [[Non-Hodgkin’s lymphoma]] | # [[Non-Hodgkin’s lymphoma]] |
Revision as of 23:37, 15 November 2018
Glanzmann's thrombasthenia |
Differentiating Glanzmann's thrombasthenia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]
Overview
The most potent risk factor in the heritable Glanzmann thrombasthenia is consanguineous marriage. [1]
Autoantibodies production cause of acquired Glanzmann thrombasthenia .
Risk Factors
Common risk factors that increase autoantibodies production in acquired Glanzmann thrombasthenia include:
- Hematologic disorders and malignancies, such as :[2]
- Acute lymphoblastic leukemia
- Non-Hodgkin’s lymphoma
- Multiple myeloma
- Hairy cell leukemia
- Myelodysplastic syndrome
- Immune thrombocytopenic purpura (ITP)
- Autoimmune diseases, such as Lupus [3]
- Drugs : anti-thrombotic drugs use , like abciximab, eptifibatide, and tirofiban which all antagonize αIIbβ3
- Platelet transfusions. [4]
References
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMC 5922622. PMID 10.1002/ajh.20159 DOI: 10.1002/ajh.20159 Check
|pmid=
value (help). - ↑ Nurden AT (April 2006). "Glanzmann thrombasthenia". Orphanet J Rare Dis. 1: 10. doi:10.1186/1750-1172-1-10. PMC 1475837. PMID 16722529.
- ↑ Blickstein D, Dardik R, Rosenthal E, Lahav J, Molad Y, Inbal A (2014). "Acquired thrombasthenia due to inhibitory effect of glycoprotein IIbIIIa autoantibodies". Isr Med Assoc J. 16 (5): 307–10. PMID 24979837.
- ↑ Solh T, Botsford A, Solh M (2015). "Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options". J Blood Med. 6: 219–27. doi:10.2147/JBM.S71319. PMC 4501245. PMID 26185478.