Polyarteritis nodosa laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
* There are no specific lab tests for diagnosing polyarteritis nodosa. | * There are no specific lab tests for diagnosing polyarteritis nodosa. | ||
* Diagnosis is generally based upon the physical examination and a few laboratory studies that help to confirm the diagnosis: | * Diagnosis is generally based upon the physical examination and a few laboratory studies that help to confirm the diagnosis. | ||
* Laboratory findings consistent with the diagnosis of PAN include | |||
** [[Complete blood count|CBC]] may show: | |||
*** Leukocytosis | |||
*** Normochromic anemia | |||
*** thrombocytosis | |||
** [[Erythrocyte sedimentation rate|ESR]] and [[C-reactive protein]]<ref name="pmid12350194">{{cite journal |vauthors=Stone JH |title=Polyarteritis nodosa |journal=JAMA |volume=288 |issue=13 |pages=1632–9 |date=October 2002 |pmid=12350194 |doi= |url=}}</ref> | |||
*** These can be helpful to diagnose active disease. | |||
** Perinuclear pattern of [[antineutrophil cytoplasmic antibodies]] ([[p-ANCA]]) - not associated with "classic" polyarteritis nodosa, but is present in a form of the disease affecting smaller blood vessels, known as [[microscopic polyangiitis]] or leukocytoclastic angiitis. | |||
** Hepatitis B surface antigen and hepatitic C serologies | |||
*** Patients with HBV related PAN show: | |||
**** Decreased levels of serum C3 and C4. | |||
**** Circulating immune complexes | |||
**** Cryoglobulins | |||
** Elevated levels of liver enzymes | |||
** Elevated creatinine level | |||
** Hypergammaglobulinemia | |||
*** Seen in 30% patients with PAN. | |||
* | |||
=== | ====== TOOLabel ====== | ||
* [ | View More | ||
* | * Overview | ||
* | * Presentation | ||
* | * DDx | ||
* [null Workup] | |||
** Approach Considerations | |||
** Imaging Studies | |||
** Biopsy | |||
** Histologic Findings | |||
** Staging | |||
** Show All | |||
* Treatment | |||
* Medication | |||
* [null Media Gallery] | |||
* [null References] | |||
==References== | ==References== | ||
Revision as of 18:08, 21 May 2018
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Polyarteritis nodosa Microchapters |
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Polyarteritis nodosa laboratory findings On the Web |
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American Roentgen Ray Society Images of Polyarteritis nodosa laboratory findings |
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Risk calculators and risk factors for Polyarteritis nodosa laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Haritha Machavarapu, M.B.B.S.
Overview
Laboratory Findings
- There are no specific lab tests for diagnosing polyarteritis nodosa.
- Diagnosis is generally based upon the physical examination and a few laboratory studies that help to confirm the diagnosis.
- Laboratory findings consistent with the diagnosis of PAN include
- CBC may show:
- Leukocytosis
- Normochromic anemia
- thrombocytosis
- ESR and C-reactive protein[1]
- These can be helpful to diagnose active disease.
- Perinuclear pattern of antineutrophil cytoplasmic antibodies (p-ANCA) - not associated with "classic" polyarteritis nodosa, but is present in a form of the disease affecting smaller blood vessels, known as microscopic polyangiitis or leukocytoclastic angiitis.
- Hepatitis B surface antigen and hepatitic C serologies
- Patients with HBV related PAN show:
- Decreased levels of serum C3 and C4.
- Circulating immune complexes
- Cryoglobulins
- Patients with HBV related PAN show:
- Elevated levels of liver enzymes
- Elevated creatinine level
- Hypergammaglobulinemia
- Seen in 30% patients with PAN.
- CBC may show:
TOOLabel
View More
- Overview
- Presentation
- DDx
- [null Workup]
- Approach Considerations
- Imaging Studies
- Biopsy
- Histologic Findings
- Staging
- Show All
- Treatment
- Medication
- [null Media Gallery]
- [null References]