Adenocarcinoma of the lung biopsy: Difference between revisions
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:** Well differentiated (low grade): Normal appearance | :** Well differentiated (low grade): Normal appearance | ||
:** Poorly differentiated (high grade): Abnormal [[Gland|glandular]] appearance with a positive mucin stain | :** Poorly differentiated (high grade): Abnormal [[Gland|glandular]] appearance with a positive mucin stain | ||
=== Histopathological subtype: === | |||
* [[Biopsy]] specimen may show different [[Histology|histological]] subtypes. | |||
* For information on [[Histology|histological subtypes]] of adenocarcinoma of the lung and their [[Histopathology|histopathological]] feature, [[Adenocarcinoma of the lung pathophysiology#Histological Subtypes|'''click here''']]. | |||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Latest revision as of 18:46, 20 February 2019
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Adenocarcinoma of the Lung Microchapters |
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Differentiating Adenocarcinoma of the Lung from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Adenocarcinoma of the lung biopsy On the Web |
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American Roentgen Ray Society Images of Adenocarcinoma of the lung biopsy |
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Risk calculators and risk factors for Adenocarcinoma of the lung biopsy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Biopsy is the diagnostic study of choice for adenocarcinoma of the lung. On microscopic histopathological analysis, nuclear atypia, eccentrically placed nuclei, abundant cytoplasm, and conspicuous nucleoli are characteristic findings of adenocarcinoma of the lung. Atypical adenomatous hyperplasia (AAH) is the precursor of peripheral adenocarcinomas. It consists of well-demarcated columnar or cuboidal cells with varying degrees of cytologic atypia, hyperchromasia, pleomorphism and prominent nucleoli.
Biopsy
- Biopsy is helpful in the diagnosis of adenocarcinoma of the lung.
- Fine needle aspiration (FNA)[1]:
- CT guided FNA uses a small amount of tissue from a suspected lung tumor or from a lymph node in the chest.
- FNA may also be obtained during bronchoscopy, along with endobronchial ultrasound, to take samples of lymph nodes around the trachea and bronchi.
- Fine needle aspiration (FNA)[1]:
- Thoracentesis
- Thoracentesis may be done to remove fluid from around the lungs to see if it contains cancer cells.
- On microscopic histopathological analysis, nuclear atypia, eccentrically placed nuclei, abundant cytoplasm, and conspicuous nucleoli are characteristic findings of adenocarcinoma of the lung.
- Atypical adenomatous hyperplasia (AAH): is the precursor of peripheral adenocarcinomas. It consists of well demarcated columnar or cuboidal cells with the following features:[2][3]
- Varying degrees of cytologic atypia
- Hyperchromasia
- Pleomorphism
- Prominent nucleoli
- As adenocarcinoma is a derivative of mucus producing glands in the lungs, it tends to stain mucin positive.
- Based on differentiation, the tumor may be:
- Well differentiated (low grade): Normal appearance
- Poorly differentiated (high grade): Abnormal glandular appearance with a positive mucin stain
- Thoracentesis
Histopathological subtype:
- Biopsy specimen may show different histological subtypes.
- For information on histological subtypes of adenocarcinoma of the lung and their histopathological feature, click here.
References
- ↑ Lung cancer. Canadian Cancer Society 2015.http://www.cancer.ca/en/cancer-information/cancer-type/lung/diagnosis/?region=ab#Endoscopy
- ↑ Kumar, Vinay (2007). Robbins basic pathology. Philadelphia, PA: Saunders/Elsevier. ISBN 1416029737.
- ↑ Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.