Hiatus hernia pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
It is | It is understood that hiatus hernia is the result of either decreased elastin of phrenoesophageal membrane due to aging that increases the risk of developing hiatal hernia. Pressure gradient between intra-abdominal and intra-thoracic pressure leads to the esophagogastric junction being displaced into normal hiatus.A rise in intraabdominal pressure and lower thoracic pressure can cause hernia. Esophageal shortening, pulls the junction into the hiatus. This physiological shortening occurs as a normal response to swallowing. The LES is shorter and weaker in large hiatus hernia and have severe reflux symptoms and trauma. Paraesophageal hernia are less common and have lesser incidence of GERD. | ||
The | |||
==Pathophysiology== | ==Pathophysiology== | ||
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****Physical strain | ****Physical strain | ||
**Esophageal shortening, pulls the junction into the hiatus. This physiological shortening occurs as a normal response to swallowing.<ref name="pmid10718444">{{cite journal |vauthors=Christensen J, Miftakhov R |title=Hiatus hernia: a review of evidence for its origin in esophageal longitudinal muscle dysfunction |journal=Am. J. Med. |volume=108 Suppl 4a |issue= |pages=3S–7S |year=2000 |pmid=10718444 |doi= |url=}}</ref>The LES is | **Esophageal shortening, pulls the junction into the hiatus. This physiological shortening occurs as a normal response to swallowing.<ref name="pmid10718444">{{cite journal |vauthors=Christensen J, Miftakhov R |title=Hiatus hernia: a review of evidence for its origin in esophageal longitudinal muscle dysfunction |journal=Am. J. Med. |volume=108 Suppl 4a |issue= |pages=3S–7S |year=2000 |pmid=10718444 |doi= |url=}}</ref>The LES is shorter and weaker in large hiatus hernia and have severe reflux symptoms <ref name="pmid8554137">{{cite journal |vauthors=Patti MG, Goldberg HI, Arcerito M, Bortolasi L, Tong J, Way LW |title=Hiatal hernia size affects lower esophageal sphincter function, esophageal acid exposure, and the degree of mucosal injury |journal=Am. J. Surg. |volume=171 |issue=1 |pages=182–6 |year=1996 |pmid=8554137 |doi=10.1016/S0002-9610(99)80096-8 |url=}}</ref> | ||
**Trauma | **Trauma | ||
*The symptoms in hiatus hernia are the result of reflux esophagitis and the mechanisms involved are:<ref name="pmid10075953">{{cite journal |vauthors=Kahrilas PJ, Lin S, Chen J, Manka M |title=The effect of hiatus hernia on gastro-oesophageal junction pressure |journal=Gut |volume=44 |issue=4 |pages=476–82 |year=1999 |pmid=10075953 |pmc=1727465 |doi= |url=}}</ref> | *The symptoms in hiatus hernia are the result of reflux esophagitis and the mechanisms involved are:<ref name="pmid10075953">{{cite journal |vauthors=Kahrilas PJ, Lin S, Chen J, Manka M |title=The effect of hiatus hernia on gastro-oesophageal junction pressure |journal=Gut |volume=44 |issue=4 |pages=476–82 |year=1999 |pmid=10075953 |pmc=1727465 |doi= |url=}}</ref> |
Revision as of 21:49, 7 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]
Overview
It is understood that hiatus hernia is the result of either decreased elastin of phrenoesophageal membrane due to aging that increases the risk of developing hiatal hernia. Pressure gradient between intra-abdominal and intra-thoracic pressure leads to the esophagogastric junction being displaced into normal hiatus.A rise in intraabdominal pressure and lower thoracic pressure can cause hernia. Esophageal shortening, pulls the junction into the hiatus. This physiological shortening occurs as a normal response to swallowing. The LES is shorter and weaker in large hiatus hernia and have severe reflux symptoms and trauma. Paraesophageal hernia are less common and have lesser incidence of GERD.
Pathophysiology
Anatomy and physiology
- Lower esophageal sphincter (LES) is the group of smooth muscles in the distal esophagus at the gastroesophageal junction.
- LES prevents the reflux of food.
- Following are the mechanisms/structures preventing the reflux:
- Angle of His: angle between cardia stomach and distal portion of esophagus. It functions as valve or flap.
- Diaphragmatic crura
- LES pressure as compared to intraabdominal pressure
- Phrenoesophageal membrane
- Phrenoesophageal ligament/membrane is fibrous elastic connective tissue arising from crura and inserts circumferentially into esophageal muscles.
- It maintains and support LES by anchoring it during peristalsis.
Pathogenesis
- It is understood that hiatus hernia is the result of either:[4]
- Decreased elastin of phrenoesophageal membrane due to aging that increases the risk of developing hiatal hernia[5][6]
- Pressure gradient between intra-abdominal and intra-thoracic pressure leads to the esophagogastric junction being displaced into normal hiatus.A rise in intraabdominal pressure and lower thoracic pressure can cause hernia.[7]
- Esophageal shortening, pulls the junction into the hiatus. This physiological shortening occurs as a normal response to swallowing.[9]The LES is shorter and weaker in large hiatus hernia and have severe reflux symptoms [10]
- Trauma
- The symptoms in hiatus hernia are the result of reflux esophagitis and the mechanisms involved are:[4]
- Low resting LES pressure
- Prolonged time taken to clear acid
- Delayed gastric emptying
- Transient LES relaxation which occurs more frequently in hiatus hernia
- The pathophysiology of hiatus hernia depends on the histological subtype:[11]
- Paraesophageal hernia are less common and have lesser incidence of GERD.
- The initial clinical signs of dysphagia, postprandial nausea and vomiting are a result of impaired gastric emptying caused by mechanical obstruction.
- It enlarges with time and symptoms are related to the abnormal intrathoracic location of the stomach
- The gastrosplenic and gastrocolic ligamenst are laxed.
- The hiatus hernia reduces LES sphincter.[4]
Video shows formation of hiatus hernia
{{#ev:youtube|vYP1mHLEGEw}}
Genetics
- Hiatus hernia is possibly transmitted in autosomal dominant to male to male inheritance pattern.[12][13][14][15]
- Sliding hiatus hernia is usually sporadic but some cases have been seen following familial pattern, as do the paraoesophageal hiatus hernia.[16]
Associated Conditions
- Gastroesophageal reflux disease[17]
- Esophagal ring[18]
- Congenital diaphragmatic hernia[12][19]
- Epiphrenic diverticula[20]
Gross Pathology
- On gross pathology, following are characteristic findings of hiatus hernia:[18]
- Herniated portion gets dilated and undergo ischemic changes
- Ischemic necrosis can be seen
Microscopic Pathology
- On microscopic histopathological analysis, variable chronic inflammation, ischemia and necrosis can be seen in hiatus hernia.[18]
References
- ↑ - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=44924605
- ↑ Boeckxstaens GE (2005). "The lower oesophageal sphincter". Neurogastroenterol. Motil. 17 Suppl 1: 13–21. doi:10.1111/j.1365-2982.2005.00661.x. PMID 15836451.
- ↑ Sivacolundhu RK, Read RA, Marchevsky AM (2002). "Hiatal hernia controversies--a review of pathophysiology and treatment options". Aust. Vet. J. 80 (1–2): 48–53. PMID 12180879.
- ↑ 4.0 4.1 4.2 Kahrilas PJ, Lin S, Chen J, Manka M (1999). "The effect of hiatus hernia on gastro-oesophageal junction pressure". Gut. 44 (4): 476–82. PMC 1727465. PMID 10075953.
- ↑ Wolf BS (1973). "Sliding hiatal hernia: the need for redefinition". Am J Roentgenol Radium Ther Nucl Med. 117 (2): 231–47. PMID 4734411.
- ↑ Friedland GW (1978). "Progress in radiology: historical review of the changing concepts of lower esophageal anatomy: 430 B.C.--1977". AJR Am J Roentgenol. 131 (3): 373–8. doi:10.2214/ajr.131.3.373. PMID 98978.
- ↑ Menezes, Mariano A.; Herbella, Fernando A. M. (2017). "Pathophysiology of Gastroesophageal Reflux Disease". World Journal of Surgery. 41 (7): 1666–1671. doi:10.1007/s00268-017-3952-4. ISSN 0364-2313.
- ↑ https://my.clevelandclinic.org/health/diseases/8098-hiatal-hernia
- ↑ Christensen J, Miftakhov R (2000). "Hiatus hernia: a review of evidence for its origin in esophageal longitudinal muscle dysfunction". Am. J. Med. 108 Suppl 4a: 3S–7S. PMID 10718444.
- ↑ Patti MG, Goldberg HI, Arcerito M, Bortolasi L, Tong J, Way LW (1996). "Hiatal hernia size affects lower esophageal sphincter function, esophageal acid exposure, and the degree of mucosal injury". Am. J. Surg. 171 (1): 182–6. doi:10.1016/S0002-9610(99)80096-8. PMID 8554137.
- ↑ Kahrilas PJ, Kim HC, Pandolfino JE (2008). "Approaches to the diagnosis and grading of hiatal hernia". Best Pract Res Clin Gastroenterol. 22 (4): 601–16. doi:10.1016/j.bpg.2007.12.007. PMC 2548324. PMID 18656819.
- ↑ 12.0 12.1 Goodman, R. M.; Wooley, C. F.; Ruppert, R. D.; Freimanis, A. K. (1969). "A Possible Genetic Role in Esophageal Hiatus Hernia". Journal of Heredity. 60 (2): 71–74. doi:10.1093/oxfordjournals.jhered.a107936. ISSN 1465-7333.
- ↑ Carré IJ, Johnston BT, Thomas PS, Morrison PJ (1999). "Familial hiatal hernia in a large five generation family confirming true autosomal dominant inheritance". Gut. 45 (5): 649–52. PMC 1727703. PMID 10517898.
- ↑ Sillero C, Reyes A, Pérez-Mateo M, Vázquez N, Alonso P, Arenas M (1984). "[Hiatal hernia of familial nature]". Rev Clin Esp (in Spanish; Castilian). 172 (2): 79–81. PMID 6718778.
- ↑ Gryglewski A, Pena IZ, Tomaszewski KA, Walocha JA (2014). "Unsolved questions regarding the role of esophageal hiatus anatomy in the development of esophageal hiatal hernias". Adv Clin Exp Med. 23 (4): 639–44. PMID 25166451.
- ↑ Baglaj SM, Noblett HR (1999). "Paraoesophageal hernia in children: familial occurrence and review of the literature". Pediatr. Surg. Int. 15 (2): 85–7. doi:10.1007/s003830050522. PMID 10079336.
- ↑ Gatopoulou A, Mimidis K, Giatromanolaki A, Papadopoulos V, Polychronidis A, Lyratzopoulos N, Sivridis E, Minopoulos G (2005). "Impact of hiatal hernia on histological pattern of non-erosive reflux disease". BMC Gastroenterol. 5: 2. doi:10.1186/1471-230X-5-2. PMC 546187. PMID 15638947.
- ↑ 18.0 18.1 18.2 Haber, Meryl (2002). Differential diagnosis in surgical pathology. Philadelphia: Saunders. ISBN 9780721690537.
- ↑ Furtado R, Le Page P, Falk G (2013). "'Pantaloon' diaphragmatic hernia masquerading as a paraoesophageal hiatal hernia". ANZ J Surg. 83 (12): 994–5. doi:10.1111/ans.12252. PMID 24289054.
- ↑ Tedesco P, Fisichella PM, Way LW, Patti MG (2005). "Cause and treatment of epiphrenic diverticula". Am. J. Surg. 190 (6): 891–4. doi:10.1016/j.amjsurg.2005.08.016. PMID 16307941.
- ↑ CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=1784490