Adult T-cell leukemia epidemiology and demographics: Difference between revisions
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* The majority of adult T-cell leukemia cases are reported in Japan, the Caribbean, South America, and Africa. | * The majority of adult T-cell leukemia cases are reported in Japan, the Caribbean, South America, and Africa. | ||
===Incidence=== | ===Incidence=== | ||
* In southern Japan, the age-adjusted incidence rate of adult T-cell leukemia is approximately 6.6 per 100,000 individuals. | * In southern Japan, the age-adjusted incidence rate of adult T-cell leukemia is approximately 6.6 per 100,000 individuals. | ||
* The annual incidence of adult T-cell leukemia development among HTLV-1 carriers is approximately 60 per 100,000 individuals. | |||
===Age=== | ===Age=== | ||
* The incidence of adult T-cell leukemia increases with age; the median age at diagnosis is 57 years. | * The incidence of adult T-cell leukemia increases with age; the median age at diagnosis is 57 years. | ||
Revision as of 15:51, 24 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
The majority of adult T-cell leukemia cases are reported in Japan, the Caribbean, South America, and Africa. In southern Japan, the age-adjusted incidence rate of adult T-cell leukemia is approximately 6.6 per 100,000 individuals. The incidence of adult T-cell leukemia increases with age; the median age at diagnosis is 57 years. Females are more commonly affected with adult T-cell leukemia than males. Males are more commonly affected with adult T-cell leukemia than females. The male to female ratio is approximately 1.4 to 1. Adult T-cell leukemia usually affects individuals of the African American, Latin american, and Asian race. Caucasian individuals are less likely to develop adult T-cell leukemia.[1][2]
Epidemiology and Demographics
Prevalence
- In the US, adult T-cell leukemia is considered a rare disease that mainly tends to affect African American intravenous drug abusers.
- The majority of adult T-cell leukemia cases are reported in Japan, the Caribbean, South America, and Africa.
Incidence
- In southern Japan, the age-adjusted incidence rate of adult T-cell leukemia is approximately 6.6 per 100,000 individuals.
- The annual incidence of adult T-cell leukemia development among HTLV-1 carriers is approximately 60 per 100,000 individuals.
Age
- The incidence of adult T-cell leukemia increases with age; the median age at diagnosis is 57 years.
- The age of onset for adult T-cell leukemia differs across geographical regions, such as:
- The median age at diagnosis in Japan is 60 years
- The median age at diagnosis in Central America is 40 years
Gender
- Males are more commonly affected with adult T-cell leukemia than females. The male to female ratio is approximately 1.4 to 1.
- Females are more commonly affected with HTLV infection than males.
- However, the risk of adult T-cell leukemia development among HTLV male carriers is five fold higher than the risk of adult T-cell leukemia development among HTLV female carriers.
Race
- Adult T-cell leukemia usually affects individuals of the African American, Latin american, and Asian race. Caucasian individuals are less likely to develop adult T-cell leukemia.
References
- ↑ Satake M, Yamada Y, Atogami S, Yamaguchi K (2015). "The incidence of adult T-cell leukemia/lymphoma among human T-lymphotropic virus type 1 carriers in Japan". Leuk Lymphoma. 56 (6): 1806–12. doi:10.3109/10428194.2014.964700. PMID 25219595.
- ↑ Iwanaga M, Watanabe T, Yamaguchi K (2012). "Adult T-cell leukemia: a review of epidemiological evidence". Front Microbiol. 3: 322. doi:10.3389/fmicb.2012.00322. PMC 3437524. PMID 22973265.