Adenocarcinoma of the lung biopsy: Difference between revisions

Jump to navigation Jump to search
No edit summary
Line 6: Line 6:


==Biopsy==
==Biopsy==
* [[Biopsy]] is helpful in the diagnosis of adenocarcinoma of the lung.
* [[Biopsy]] is helpful in the diagnosis of adenocarcinoma of the lung.  
* During a biopsy, tissues or cells are removed from the body so they can be tested in a laboratory. The pathology report from the laboratory will confirm whether or not cancer cells are present in the sample. The biopsies that could be used for lung cancer are:<ref name=cancada>Lung cancer. Canadian Cancer Society 2015.http://www.cancer.ca/en/cancer-information/cancer-type/lung/diagnosis/?region=ab#Endoscopy</ref>
** [[Fine needle aspiration]] (FNA)<ref name="cancada">Lung cancer. Canadian Cancer Society 2015.http://www.cancer.ca/en/cancer-information/cancer-type/lung/diagnosis/?region=ab#Endoscopy</ref>:
:* [[Fine needle aspiration]] (FNA)
*** CT guided FNA uses a small amount of tissue from a suspected lung tumour or from a lymph node in the chest.  
::* The doctor may use a CT scan to guide FNA to remove a small amount of tissue from a suspected lung tumour or from a lymph node in the chest.
*** FNA may also be obtained during bronchoscopy, along with endobronchial ultrasound, to take samples of lymph nodes around the trachea and bronchi.  
::* FNA may also be done during bronchoscopy, along with endobronchial ultrasound, to take samples of lymph nodes around the trachea and the bronchi.
:* [[Thoracentesis]]  
:* [[Thoracentesis]]
:** Thoracentesis may be done to remove fluid from around the lungs to see if it contains cancer cells.
::* Thoracentesis may be done to remove fluid from around the lungs to see if it contains cancer cells.
:* On microscopic histopathological analysis, nuclear atypia, eccentrically placed [[Cell nucleus|nuclei]], abundant [[cytoplasm]], and conspicuous [[Nucleolus|nucleoli]] are characteristic findings of adenocarcinoma of the lung
* To view the biopsy findings of adenocarcinoma of the lung, please click [[adenocarcinoma of the lung pathophysiology|'''here''']].
:* Atypical adenomatous hyperplasia (AAH): is the precursor of peripheral adenocarcinomas.  It consists of well demarcated [[Columnar epithelia|columnar]] or [[Cuboidal epithelia|cuboidal]] cells with the following features:<ref>{{cite book | last = Kumar | first = Vinay | title = Robbins basic pathology | publisher = Saunders/Elsevier | location = Philadelphia, PA | year = 2007 | isbn = 1416029737 }}</ref><ref>{{cite book | last = Stewart | first = Bernard | title = World cancer report 2014 | publisher = International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization | location = Lyon, France Geneva, Switzerland | year = 2014 | isbn = 9283204298 }}</ref>
:** Varying degrees of cytologic [[atypia]] 
:** Hyperchromasia 
:** [[Pleomorphism]] 
:** Prominent [[nucleoli]] 
:* As adenocarcinoma is a derivative of [[mucus]] producing glands in the lungs, it tends to stain [[mucin]] positive. 
:* Based on differentiation, the [[tumor]] may be:
:** Well differentiated (low grade): Normal appearance 
:** Poorly differentiated (high grade): Abnormal [[Gland|glandular]] appearance with a positive mucin stain
:* '''Subtypes'''<ref name="libre">Adenocarcinoma of the lung. Librepathology 2015. http://librepathology.org/wiki/index.php/Adenocarcinoma_of_the_lung#Microscopic Accessed on December 20, 2015</ref>
:**Lepidic predominant:
:*:*[[Tumor]] grows long the [[Alveolus|alveolar]] wall
:**[[Acinus|Acinar]] predominant:
:*:*Berry-shaped glands, smaller than lung [[Acinus|acini]]
:**[[Papillary]] predominant:
:*:*Fibrovascular cores
:**Micropapillary predominant:
:*:*Nipple shaped projections without fibrovascular cores
:**Solid predominant:
:*:*Sheet of [[Cell (biology)|cells]]


==References==
==References==

Revision as of 21:56, 2 March 2018

Adenocarcinoma of the Lung Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Adenocarcinoma of the Lung from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

Staging

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

Echocardiography and Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Intervention

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Adenocarcinoma of the lung biopsy On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Adenocarcinoma of the lung biopsy

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Adenocarcinoma of the lung biopsy

CDC on Adenocarcinoma of the lung biopsy

Adenocarcinoma of the lung biopsy in the news

Blogs on Adenocarcinoma of the lung biopsy

Directions to Hospitals Treating Adenocarcinoma of the lung

Risk calculators and risk factors for Adenocarcinoma of the lung biopsy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

Biopsy is helpful in the diagnosis of adenocarcinoma of the lung.[1]

Biopsy

  • Biopsy is helpful in the diagnosis of adenocarcinoma of the lung.
    • Fine needle aspiration (FNA)[1]:
      • CT guided FNA uses a small amount of tissue from a suspected lung tumour or from a lymph node in the chest.
      • FNA may also be obtained during bronchoscopy, along with endobronchial ultrasound, to take samples of lymph nodes around the trachea and bronchi.
  • Thoracentesis
    • Thoracentesis may be done to remove fluid from around the lungs to see if it contains cancer cells.
  • On microscopic histopathological analysis, nuclear atypia, eccentrically placed nuclei, abundant cytoplasm, and conspicuous nucleoli are characteristic findings of adenocarcinoma of the lung.
  • Atypical adenomatous hyperplasia (AAH): is the precursor of peripheral adenocarcinomas. It consists of well demarcated columnar or cuboidal cells with the following features:[2][3]
  • As adenocarcinoma is a derivative of mucus producing glands in the lungs, it tends to stain mucin positive.
  • Based on differentiation, the tumor may be:
    • Well differentiated (low grade): Normal appearance
    • Poorly differentiated (high grade): Abnormal glandular appearance with a positive mucin stain
  • Subtypes[4]
    • Lepidic predominant:
    • Berry-shaped glands, smaller than lung acini
    • Fibrovascular cores
    • Micropapillary predominant:
    • Nipple shaped projections without fibrovascular cores
    • Solid predominant:

References

  1. 1.0 1.1 Lung cancer. Canadian Cancer Society 2015.http://www.cancer.ca/en/cancer-information/cancer-type/lung/diagnosis/?region=ab#Endoscopy
  2. Kumar, Vinay (2007). Robbins basic pathology. Philadelphia, PA: Saunders/Elsevier. ISBN 1416029737.
  3. Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.
  4. Adenocarcinoma of the lung. Librepathology 2015. http://librepathology.org/wiki/index.php/Adenocarcinoma_of_the_lung#Microscopic Accessed on December 20, 2015


Template:WikiDoc Sources