Gestational trophoblastic neoplasia laboratory findings: Difference between revisions

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{{Choriocarcinoma}}
{{Gestational trophoblastic neoplasia}}
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==Overview==
Elevated serum [[human chorionic gonadotropin]] is diagnostic of choriocarcinoma.<ref name=abc> Diagnosing gestational trophoblastic disease. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/gestational-trophoblastic-disease/diagnosis/?region=ns Accessed on October 13, 2015</ref><ref name= aaa> Choriocarcinoma. librepathology.org. http://librepathology.org/wiki/index.php/Choriocarcinoma Accessed on October 8, 2015</ref>
==Laboratory Findings==
===Quantitative serum HCG===
* [[Human chorionic gonadotropin]] (HCG or b-HCG) is the most common [[tumor]] marker test used to diagnose GTD<ref name=abc> Diagnosing gestational trophoblastic disease. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/gestational-trophoblastic-disease/diagnosis/?region=ns Accessed on October 13, 2015</ref>
* HCG is markedly elevated (usu. >10,000 IU)<ref name= aaa> Choriocarcinoma. librepathology.org. http://librepathology.org/wiki/index.php/Choriocarcinoma Accessed on October 8, 2015</ref>
* HCG is a very sensitive test for diagnosing most gestational trophoblastic tumors
* HCG is usually measured in the blood, but it can also be measured in the [[urine]]
* HCG levels are much higher in women with complete [[hydatidiform mole]]s and gestational choriocarcinoma compared to HCG levels in women with a normal [[pregnancy]]
* With partial moles, the HCG level is higher than normal, but it is not as high as with other types of GTD
* With [[placental]] site tumors, the HCG level may be slightly higher than normal, but it is not considered a good marker for this type of tumor
* An HCG test can help find GTD after pregnancy or [[miscarriage]] as this hormone should not be present in the blood or urine soon afterward


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===Human placental lactogen (hPL)===
* Human placental lactogen (hPL) is a tumor marker that may be used to follow women with placental site [[trophoblastic]] tumors
* Elevated hPL levels are found in women with some types of GTD
===Complete blood count===
* [[Complete blood count]] can check for [[anemia ]] from long-term (chronic) [[vaginal bleeding]]


==Overview==
===Kidney function tests===
Increased quantitative [[human chorionic gonadotropin|beta HCG]] levels
===Liver function tests===


==References==
==References==
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Latest revision as of 23:36, 26 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

Overview

Elevated serum human chorionic gonadotropin is diagnostic of choriocarcinoma.[1][2]

Laboratory Findings

Quantitative serum HCG

  • Human chorionic gonadotropin (HCG or b-HCG) is the most common tumor marker test used to diagnose GTD[1]
  • HCG is markedly elevated (usu. >10,000 IU)[2]
  • HCG is a very sensitive test for diagnosing most gestational trophoblastic tumors
  • HCG is usually measured in the blood, but it can also be measured in the urine
  • HCG levels are much higher in women with complete hydatidiform moles and gestational choriocarcinoma compared to HCG levels in women with a normal pregnancy
  • With partial moles, the HCG level is higher than normal, but it is not as high as with other types of GTD
  • With placental site tumors, the HCG level may be slightly higher than normal, but it is not considered a good marker for this type of tumor
  • An HCG test can help find GTD after pregnancy or miscarriage as this hormone should not be present in the blood or urine soon afterward

Human placental lactogen (hPL)

  • Human placental lactogen (hPL) is a tumor marker that may be used to follow women with placental site trophoblastic tumors
  • Elevated hPL levels are found in women with some types of GTD

Complete blood count

Kidney function tests

Liver function tests

References

  1. 1.0 1.1 Diagnosing gestational trophoblastic disease. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/gestational-trophoblastic-disease/diagnosis/?region=ns Accessed on October 13, 2015
  2. 2.0 2.1 Choriocarcinoma. librepathology.org. http://librepathology.org/wiki/index.php/Choriocarcinoma Accessed on October 8, 2015

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