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__NOTOC__
__NOTOC__
{{Aplastic anemia}}
{{Aplastic anemia}}
{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh13579@gmail.com]  {{N.F}}
{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh13579@gmail.com]  {{N.F}}
==Overview==
==Overview==
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{| class="wikitable"
{| class="wikitable"
|+ '''Classification of aplastic anemia (two out of three criteria must be met)'''
|+ '''Classification of aplastic anemia (two out of three criteria must be met)'''
!
!style="background: #4479BA; color: #FFFFFF; " |
!nSAA
!style="background: #4479BA; color: #FFFFFF; " |nSAA
!SAA
!style="background: #4479BA; color: #FFFFFF; " |SAA
!vSAA
!style="background: #4479BA; color: #FFFFFF; " |vSAA
|-
|-
|[[Reticulocytes]]
| style="background: #DCDCDC; text-align: center;" |[[Reticulocytes]]
|<20G/L
| style="background: #F5F5F5; text-align: center;" |<20G/L
|<20G/L
| style="background: #F5F5F5; text-align: center;" |<20G/L
|<20G/L                                       
| style="background: #F5F5F5; text-align: center;" |<20G/L                                       
|-
|-
|[[Platelet|Platelets]]
| style="background: #DCDCDC; text-align: center;" |[[Platelet|Platelets]]
|<50 G / L                               
| style="background: #F5F5F5; text-align: center;" |<50 G / L                               
|<20G/L                               
| style="background: #F5F5F5; text-align: center;" |<20G/L                               
|<20G/L                                   
| style="background: #F5F5F5; text-align: center;" |<20G/L                                   
|-
|-
|[[Granulocytes|Neutrophilic granulocytes]]
| style="background: #DCDCDC; text-align: center;" |[[Granulocytes|Neutrophilic granulocytes]]
|<1.0 G / L
| style="background: #F5F5F5; text-align: center;" |<1.0 G / L
|<0.5G/L
| style="background: #F5F5F5; text-align: center;" |<0.5G/L
|0.2G/L
| style="background: #F5F5F5; text-align: center;" |0.2G/L
|}
|}
This classification is of prognostic relevance and has an influence on therapeutic procedures.
This classification is of prognostic relevance and has an influence on therapeutic procedures.
Line 39: Line 37:
==Classification based on the presumed etiology==
==Classification based on the presumed etiology==
{| class="wikitable"
{| class="wikitable"
|+classification based on the presumed etiology
|+Classification based on the presumed etiology
!''Acquired aplastic anemia''
!
|-
|-
|[[Idiopathic]]
! rowspan="2" style="background: #4479BA; color: #FFFFFF; " |''Acquired aplastic anemia''
|
| style="background: #DCDCDC; text-align: center;" |[[Idiopathic]]
| style="background: #F5F5F5; text-align: center;" |
|-
|-
|Secondry                
| style="background: #DCDCDC; text-align: center;" |Secondary                
|[[Irradiation]]                                                                                      
| style="background: #F5F5F5; text-align: left;" |
Drugs and chemicals: cytotoxic agents, [[benzene]], chloromphenicol, [[gold]]  
* [[Irradiation]]
 
* Drugs and chemicals: cytotoxic agents, [[benzene]], chloromphenicol, [[gold]]
salts, [[Non-steroidal anti-inflammatory drug|NSAIDS]]
salts, [[Non-steroidal anti-inflammatory drug|NSAIDS]].
 
* [[Idiosyncratic drug reaction|Idiosyncratic]] reactions
[[Idiosyncratic drug reaction|Idiosyncratic]] reactions
* Viruses: [[Epstein Barr virus]], [[parvovirus B19]], [[Human Immunodeficiency Virus (HIV)|HIV]]
 
* Immune diseases
Viruses: [[Epstein Barr virus]], [[parvovirus B19]], [[Human Immunodeficiency Virus (HIV)|HIV]]
* [[Pregnancy]]  
 
* [[PNH]] [[Paroxysmal nocturnal hemoglobinuria]]
Immune diseases
 
[[Pregnancy]]
 
[[PNH]] [[Paroxysmal nocturnal hemoglobinuria]]
|-
|-
|'''''Inherited aplastic anemia'''''
| colspan="2"  style="background: #4479BA; color: #FFFFFF; " |'''''Inherited aplastic anemia'''''
|[[Fanconi anemia]]
| style="background: #F5F5F5; text-align: left;" |
[[Dyskeratosis congenita|Dyskeratosis congenital]]
* [[Fanconi anemia]]
 
* [[Dyskeratosis congenita|Dyskeratosis congenita]]
[[Amegakaryocytic thrombocytopenia]]
* [[Amegakaryocytic thrombocytopenia]]
 
* [[Shwachman-Diamond syndrome]]
[[Shwachman-Diamond syndrome]]
|}
|}



Latest revision as of 18:55, 29 October 2018

Aplastic anemia Microchapters

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Overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2] Nazia Fuad M.D.

Overview

Aplastic anemia may be classified according to blood cell counts into 3 subgroups, moderately severe aplastic anemia or non severe AA (nSAA), severe aplastic anemia (SAA), and very severe aplastic anemia(vSAA).

Classification

Aplastic anemia may be classified according to blood cell counts into 3 subgroups:[1]

  • Moderately severe aplastic anemia or non severe AA (nSAA)
  • Severe aplastic anemia (SAA)
  • Very severe aplastic anemia(vSAA)
Classification of aplastic anemia (two out of three criteria must be met)
nSAA SAA vSAA
Reticulocytes <20G/L <20G/L <20G/L
Platelets <50 G / L <20G/L <20G/L
Neutrophilic granulocytes <1.0 G / L <0.5G/L 0.2G/L

This classification is of prognostic relevance and has an influence on therapeutic procedures.

Classification based on the presumed etiology

Classification based on the presumed etiology
Acquired aplastic anemia Idiopathic
Secondary

salts, NSAIDS.

Inherited aplastic anemia

References

  1. Dolberg OJ, Levy Y (2014). "Idiopathic aplastic anemia: diagnosis and classification". Autoimmun Rev. 13 (4–5): 569–73. doi:10.1016/j.autrev.2014.01.014. PMID 24424170.