EBF1: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Transcription factor COE1''' is a [[protein]] that in humans is encoded by the ''EBF1'' [[gene]].  
'''Transcription factor COE1''' is a [[protein]] that in humans is encoded by the ''EBF1'' [[gene]].  
EBF1 stands for '''Early B-Cell Factor 1'''.<ref>{{cite web|url=http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3126}}</ref><ref name="pmid8012110">{{cite journal | vauthors = Milatovich A, Qiu RG, Grosschedl R, Francke U | title = Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11 | journal = Mamm. Genome | volume = 5 | issue = 4 | pages = 211–5  | date = Jul 1994 | pmid = 8012110 | pmc =  | doi = 10.1007/BF00360547 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EBF1 early B-cell factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1879| accessdate = }}</ref>
EBF1 stands for '''Early B-Cell Factor 1'''.<ref>{{cite web|url = https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3126|title = Symbol Report: EBF1|website = HUGO Gene Nomenclature Committee }}</ref><ref name="pmid8012110">{{cite journal | vauthors = Milatovich A, Qiu RG, Grosschedl R, Francke U | title = Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11 | journal = Mamm. Genome | volume = 5 | issue = 4 | pages = 211–5  | date = Jul 1994 | pmid = 8012110 | pmc =  | doi = 10.1007/BF00360547 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EBF1 early B-cell factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1879| accessdate = }}</ref>


EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function.<ref>{{Cite journal|last=Treiber|first=Thomas|last2=Mandel|first2=Elizabeth M.|last3=Pott|first3=Sebastian|last4=Györy|first4=Ildiko|last5=Firner|first5=Sonja|last6=Liu|first6=Edison T.|last7=Grosschedl|first7=Rudolf|title=Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin|url=http://linkinghub.elsevier.com/retrieve/pii/S1074761310001627|journal=Immunity|volume=32|issue=5|pages=714–725|doi=10.1016/j.immuni.2010.04.013}}</ref><ref>{{Cite journal|last=Hagman|first=James|last2=Ramírez|first2=Julita|last3=Lukin|first3=Kara|date=2012-01-01|title=B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1|journal=Current Topics in Microbiology and Immunology|volume=356|pages=17–38|doi=10.1007/82_2011_139|issn=0070-217X|pmc=3925327|pmid=21735360}}</ref> The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells.<ref>{{Cite journal|last=Schwartz|first=Anton M.|last2=Putlyaeva|first2=Lidia V.|last3=Covich|first3=Milica|last4=Klepikova|first4=Anna V.|last5=Akulich|first5=Kseniya A.|last6=Vorontsov|first6=Ilya E.|last7=Korneev|first7=Kirill V.|last8=Dmitriev|first8=Sergey E.|last9=Polanovsky|first9=Oleg L.|date=2016-10-01|title=Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells|url=http://www.sciencedirect.com/science/article/pii/S1874939916301365|journal=Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms|volume=1859|issue=10|pages=1259–1268|doi=10.1016/j.bbagrm.2016.07.004}}</ref>
EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function.<ref>{{Cite journal|last=Treiber|first=Thomas|last2=Mandel|first2=Elizabeth M.|last3=Pott|first3=Sebastian|last4=Györy|first4=Ildiko|last5=Firner|first5=Sonja|last6=Liu|first6=Edison T.|last7=Grosschedl|first7=Rudolf|title=Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin|url=http://linkinghub.elsevier.com/retrieve/pii/S1074761310001627|journal=Immunity|volume=32|issue=5|pages=714–725|doi=10.1016/j.immuni.2010.04.013}}</ref><ref>{{Cite journal|last=Hagman|first=James|last2=Ramírez|first2=Julita|last3=Lukin|first3=Kara|date=2012-01-01|title=B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1|journal=Current Topics in Microbiology and Immunology|volume=356|pages=17–38|doi=10.1007/82_2011_139|issn=0070-217X|pmc=3925327|pmid=21735360}}</ref> The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells.<ref>{{Cite journal|last=Schwartz|first=Anton M.|last2=Putlyaeva|first2=Lidia V.|last3=Covich|first3=Milica|last4=Klepikova|first4=Anna V.|last5=Akulich|first5=Kseniya A.|last6=Vorontsov|first6=Ilya E.|last7=Korneev|first7=Kirill V.|last8=Dmitriev|first8=Sergey E.|last9=Polanovsky|first9=Oleg L.|date=2016-10-01|title=Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells|url=http://www.sciencedirect.com/science/article/pii/S1874939916301365|journal=Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms|volume=1859|issue=10|pages=1259–1268|doi=10.1016/j.bbagrm.2016.07.004}}</ref>
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== Interactions ==
== Interactions ==


EBF1 has been shown to [[Protein-protein interaction|interact]] with [[ZNF423]]<ref name=pmid9151733>{{cite journal | vauthors = Tsai RY, Reed RR | title = Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development | journal = J. Neurosci. | volume = 17 | issue = 11 | pages = 4159–69  | date = Jun 1997 | pmid = 9151733 }}</ref> and [[CREB binding protein]].<ref name=pmid12748286>{{cite journal | vauthors = Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T | title = Inhibition of p300/CBP by early B-cell factor | journal = Mol. Cell. Biol. | volume = 23 | issue = 11 | pages = 3837–46  | date = Jun 2003 | pmid = 12748286 | pmc = 155219 | doi = 10.1128/MCB.23.11.3837-3846.2003 }}</ref>
EBF1 has been shown to [[Protein-protein interaction|interact]] with [[ZNF423]]<ref name=pmid9151733>{{cite journal | vauthors = Tsai RY, Reed RR | title = Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development | journal = J. Neurosci. | volume = 17 | issue = 11 | pages = 4159–69  | date = Jun 1997 | pmid = 9151733 }}</ref> and [[CREB binding protein]].<ref name=pmid12748286>{{cite journal | vauthors = Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T | title = Inhibition of p300/CBP by early B-cell factor | journal = Mol. Cell. Biol. | volume = 23 | issue = 11 | pages = 3837–46  | date = Jun 2003 | pmid = 12748286 | pmc = 155219 | doi = 10.1128/MCB.23.11.3837-3846.2003 | url = http://lup.lub.lu.se/search/ws/files/2814746/624799.pdf }}</ref>


== References ==
== References ==

Latest revision as of 15:10, 4 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1.[1][2][3]

EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function.[4][5] The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells.[6]

Interactions

EBF1 has been shown to interact with ZNF423[7] and CREB binding protein.[8]

References

  1. "Symbol Report: EBF1". HUGO Gene Nomenclature Committee.
  2. Milatovich A, Qiu RG, Grosschedl R, Francke U (Jul 1994). "Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11". Mamm. Genome. 5 (4): 211–5. doi:10.1007/BF00360547. PMID 8012110.
  3. "Entrez Gene: EBF1 early B-cell factor 1".
  4. Treiber, Thomas; Mandel, Elizabeth M.; Pott, Sebastian; Györy, Ildiko; Firner, Sonja; Liu, Edison T.; Grosschedl, Rudolf. "Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin". Immunity. 32 (5): 714–725. doi:10.1016/j.immuni.2010.04.013.
  5. Hagman, James; Ramírez, Julita; Lukin, Kara (2012-01-01). "B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1". Current Topics in Microbiology and Immunology. 356: 17–38. doi:10.1007/82_2011_139. ISSN 0070-217X. PMC 3925327. PMID 21735360.
  6. Schwartz, Anton M.; Putlyaeva, Lidia V.; Covich, Milica; Klepikova, Anna V.; Akulich, Kseniya A.; Vorontsov, Ilya E.; Korneev, Kirill V.; Dmitriev, Sergey E.; Polanovsky, Oleg L. (2016-10-01). "Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859 (10): 1259–1268. doi:10.1016/j.bbagrm.2016.07.004.
  7. Tsai RY, Reed RR (Jun 1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. 17 (11): 4159–69. PMID 9151733.
  8. Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T (Jun 2003). "Inhibition of p300/CBP by early B-cell factor" (PDF). Mol. Cell. Biol. 23 (11): 3837–46. doi:10.1128/MCB.23.11.3837-3846.2003. PMC 155219. PMID 12748286.

Further reading

External links