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{{Ameloblastoma}}
{{Ameloblastoma}}
{{CMG}}{{AE}}{{Simrat}}
{{CMG}}; {{AE}} {{VKG}}, {{Simrat}}
==Overview==
==Overview==
==Natural History==
In several cases, the patients with [[ameloblastoma]] are [[asymptomatic]]. Depending on the extent of the [[tumor]] at the time of [[diagnosis]], the [[prognosis]] may vary.  
Ameloblastoma is a rare disorder of the jaw involving abnormal tissue growth. The resulting tumors or cysts are usually not malignant (benign) but the tissue growth may be aggressive in the involved area. On occasion, tissue near the jaws, such as around the sinuses and eye sockets, may become involved as well. The tissues involved are most often those that give rise to the teeth so that ameloblastoma may cause facial distortion. Malignancy is uncommon as are metastases, but they do occur. Ameloblastoma is characterized by an abnormal growth in the sinus area or jaw, often at the site of the third molar. The tumors or cysts may be aggressive and may spread to the nose, eye socket and skull. It is important for ameloblastoma to be diagnosed and treated early in order to stop growth of the tumors and possible progression to cancer. Although it is uncommon, ameloblastomas have been known to become malignant and spread to other parts of the body, especially to the lungs. The initial surgical treatment must be carefully and scrupulously done to avoid recurrence.


Ameloblastomas do not usually become malignant. There is evidence that tissue is more likely to become malignant if the condition reoccurs after surgery.
==Natural History, Complications, and Prognosis==
Ameoloblastomas tend to be treated by surgical en-bloc resection. Local curettage is associated with a high rate of local recurrence (45-90%).


Simple unicystic lesions are less common but have a better prognosis. Simple (no nodule) variant will not be diagnosable on radiography, as it will be indistinguishable form other more common cysts. Luminal variant, has a single nodule projecting into the cyst. Mural variant has multiple nodules (often only microscopic) in the wall of the cyst. The latter has an elevated risk of recurrence.
=== Natural History ===
Generally, complete surgical excision with wide surgical margins result in a good prognosis for Ameloblastoma
* In several cases, the patients with [[ameloblastoma]] are [[asymptomatic]].<ref name="pmid16026635">{{cite journal| author=Gümgüm S, Hoşgören B| title=Clinical and radiologic behaviour of ameloblastoma in 4 cases. | journal=J Can Dent Assoc | year= 2005 | volume= 71 | issue= 7 | pages= 481-4 | pmid=16026635 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16026635  }} </ref><ref name="Morgan2011">{{cite journal|last1=Morgan|first1=Peter R.|title=Odontogenic tumors: a review|journal=Periodontology 2000|volume=57|issue=1|year=2011|pages=160–76|issn=09066713|doi=10.1111/j.1600-0757.2011.00393.x}}</ref><ref name="RuslinHendra2017">{{cite journal|last1=Ruslin|first1=M|last2=Hendra|first2=FN|last3=Vojdani|first3=A|last4=Hardjosantoso|first4=D|last5=Gazali|first5=M|last6=Tajrin|first6=A|last7=Wolff|first7=J|last8=Forouzanfar|first8=T|title=The Epidemiology, treatment, and complication of ameloblastoma in East-Indonesia: 6 years retrospective study|journal=Medicina Oral Patología Oral y Cirugia Bucal|year=2017|pages=0–0|issn=16986946|doi=10.4317/medoral.22185}}</ref>
The tissue growth may be removed, but newer growths could be a frequent occurrence
* [[Ameloblastoma]] most commonly diagnosed as an accidental finding on [[orthopantomography]]. 
* The most common symptoms in patients with [[ameloblastoma]] are as following: 
** [[Facial]] swelling
** [[Malocclusion]]
** Loosening of [[teeth]]
** ILL-fitting [[dentures]]
** [[Periodontal]] diseases 
** Oroantral [[Fistula|fistulas]] and 
** [[Nasal]] airway [[obstruction]] 


* [[Ameloblastoma]] is regarded as a true neoplasm of enamel. 
* [[Ameloblastoma]] described as unicentric, nonfunctional, intermittent in growth. 
* [[Ameloblastoma]] is the second most common odontogenic neoplasm. 
* [[Ameloblastoma]] histologically classified as six subtypes:
** Follicular subtype
** Plexiform subtype 
** Acanthomatous subtype 
** Granular subtype 
** [[Desmoplastic]] subtype and 
** [[Basilar]] subtype. 
* [[Ameloblastoma]] most commonly affects [[mandible]] more than [[maxilla]].
*<nowiki/>[[Ameloblastoma]]<nowiki/>l progress as a slow growing, painless expansion of jaw
===Complications===
*[[Complications]] of [[ameloblastoma]] include the following:<ref name="RuslinHendra20172">{{cite journal|last1=Ruslin|first1=M|last2=Hendra|first2=FN|last3=Vojdani|first3=A|last4=Hardjosantoso|first4=D|last5=Gazali|first5=M|last6=Tajrin|first6=A|last7=Wolff|first7=J|last8=Forouzanfar|first8=T|title=The Epidemiology, treatment, and complication of ameloblastoma in East-Indonesia: 6 years retrospective study|journal=Medicina Oral Patología Oral y Cirugia Bucal|year=2017|pages=0–0|issn=16986946|doi=10.4317/medoral.22185}}</ref><ref name="pmid23120181">{{cite journal |vauthors=Mukhopadhyay S, Raha K, Mondal SC |title=Huge ameloblastoma of jaw-A case report |journal=Indian J Otolaryngol Head Neck Surg |volume=57 |issue=3 |pages=247–8 |date=July 2005 |pmid=23120181 |pmc=3451340 |doi=10.1007/BF03008023 |url=}}</ref>
**[[Shortness of breath|Breathing difficulty]]
**[[Pain]] and [[facial]] deformity
**Secondary [[infection]] of the [[tumor]]
*The recurrence rate of these [[tumors]] is 25-30%. 
===Prognosis===
*The [[prognosis]] of [[ameloblastoma]] was determined mainly by the method of surgical treatment, which means that patients receiving a radical treatment had a better [[prognosis]] than those who received a radical one. <ref name="RuslinHendra20173">{{cite journal|last1=Ruslin|first1=M|last2=Hendra|first2=FN|last3=Vojdani|first3=A|last4=Hardjosantoso|first4=D|last5=Gazali|first5=M|last6=Tajrin|first6=A|last7=Wolff|first7=J|last8=Forouzanfar|first8=T|title=The Epidemiology, treatment, and complication of ameloblastoma in East-Indonesia: 6 years retrospective study|journal=Medicina Oral Patología Oral y Cirugia Bucal|year=2017|pages=0–0|issn=16986946|doi=10.4317/medoral.22185}}</ref><ref name="pmid231201812">{{cite journal |vauthors=Mukhopadhyay S, Raha K, Mondal SC |title=Huge ameloblastoma of jaw-A case report |journal=Indian J Otolaryngol Head Neck Surg |volume=57 |issue=3 |pages=247–8 |date=July 2005 |pmid=23120181 |pmc=3451340 |doi=10.1007/BF03008023 |url=}}</ref>
* In more than 50% patients receiving the conservative treatment had good [[prognosis]] without any recurrence.
*[[Ameloblastoma]] which has a well-defined edge with [[sclerosis]] is thought to grow slowly, and the normal bone has a strong reaction to form the [[sclerosis]] edge, and the [[prognosis]] is good.
*<nowiki/>[[Ameloblastoma]]<nowiki/>with the ill-defined [[radiographic]] boundary, the tumor has the highest proliferative ability and poorest [[prognosis]].
*[[Radical surgery|Radical surge]]<nowiki/>[[Radical surgery|ry]] should be used for the multicystic [[ameloblastoma]] to prevent the recurrence.
*The follicular [[ameloblastoma]] were thought to have a higher recurrence rate than unicystic or plexiform.<ref name="LiHan2012">{{cite journal|last1=Li|first1=Yi|last2=Han|first2=Bo|last3=Li|first3=Long-Jiang|title=Prognostic and proliferative evaluation of ameloblastoma based on radiographic boundary|journal=International Journal of Oral Science|volume=4|issue=1|year=2012|pages=30–33|issn=1674-2818|doi=10.1038/ijos.2012.8}}</ref>


==Complications==
According to World Health Organization (WHO) ameloblastoma is a benign tumor. Metastases to the lungs or central nervous system (CNS) have rarely been reported.
Complications of ameloblastoma include the following:
*Breathing difficulty
*Pain and facial deformity
*Secondary infection of the tumor
*The recurrence rate of these tumors is 25-30%. The tumor can recur after treatment and hence, a close follow-up is needed.
==Prognosis==
==References==
==References==


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Latest revision as of 18:46, 23 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2], Simrat Sarai, M.D. [3]

Overview

In several cases, the patients with ameloblastoma are asymptomatic. Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary.

Natural History, Complications, and Prognosis

Natural History

  • Ameloblastoma is regarded as a true neoplasm of enamel.
  • Ameloblastoma described as unicentric, nonfunctional, intermittent in growth.
  • Ameloblastoma is the second most common odontogenic neoplasm.
  • Ameloblastoma histologically classified as six subtypes:
    • Follicular subtype
    • Plexiform subtype
    • Acanthomatous subtype
    • Granular subtype
    • Desmoplastic subtype and
    • Basilar subtype.

Complications

Prognosis

  • The prognosis of ameloblastoma was determined mainly by the method of surgical treatment, which means that patients receiving a radical treatment had a better prognosis than those who received a radical one. [6][7]

References

  1. ↑ Gümgüm S, Hoşgören B (2005). "Clinical and radiologic behaviour of ameloblastoma in 4 cases". J Can Dent Assoc. 71 (7): 481–4. PMID 16026635.
  2. ↑ Morgan, Peter R. (2011). "Odontogenic tumors: a review". Periodontology 2000. 57 (1): 160–76. doi:10.1111/j.1600-0757.2011.00393.x. ISSN 0906-6713.
  3. ↑ Ruslin, M; Hendra, FN; Vojdani, A; Hardjosantoso, D; Gazali, M; Tajrin, A; Wolff, J; Forouzanfar, T (2017). "The Epidemiology, treatment, and complication of ameloblastoma in East-Indonesia: 6 years retrospective study". Medicina Oral Patología Oral y Cirugia Bucal: 0–0. doi:10.4317/medoral.22185. ISSN 1698-6946.
  4. ↑ Ruslin, M; Hendra, FN; Vojdani, A; Hardjosantoso, D; Gazali, M; Tajrin, A; Wolff, J; Forouzanfar, T (2017). "The Epidemiology, treatment, and complication of ameloblastoma in East-Indonesia: 6 years retrospective study". Medicina Oral Patología Oral y Cirugia Bucal: 0–0. doi:10.4317/medoral.22185. ISSN 1698-6946.
  5. ↑ Mukhopadhyay S, Raha K, Mondal SC (July 2005). "Huge ameloblastoma of jaw-A case report". Indian J Otolaryngol Head Neck Surg. 57 (3): 247–8. doi:10.1007/BF03008023. PMC 3451340. PMID 23120181.
  6. ↑ Ruslin, M; Hendra, FN; Vojdani, A; Hardjosantoso, D; Gazali, M; Tajrin, A; Wolff, J; Forouzanfar, T (2017). "The Epidemiology, treatment, and complication of ameloblastoma in East-Indonesia: 6 years retrospective study". Medicina Oral Patología Oral y Cirugia Bucal: 0–0. doi:10.4317/medoral.22185. ISSN 1698-6946.
  7. ↑ Mukhopadhyay S, Raha K, Mondal SC (July 2005). "Huge ameloblastoma of jaw-A case report". Indian J Otolaryngol Head Neck Surg. 57 (3): 247–8. doi:10.1007/BF03008023. PMC 3451340. PMID 23120181.
  8. ↑ Li, Yi; Han, Bo; Li, Long-Jiang (2012). "Prognostic and proliferative evaluation of ameloblastoma based on radiographic boundary". International Journal of Oral Science. 4 (1): 30–33. doi:10.1038/ijos.2012.8. ISSN 1674-2818.

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