Lipoma natural history, complications and prognosis: Difference between revisions

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{{Lipoma}}
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==Overview==
==Overview==
 
Lipoma tends to affect individuals of 40 to 60 years of age. They are completely [[benign]] and recurrence is one of their [[complications]].
==Natural History==
==Natural History==
 
* Lipoma usually affects individuals of 40 to 60 years of age.<ref name="RydholmBerg2009">{{cite journal|last1=Rydholm|first1=Anders|last2=Berg|first2=Nils O.|title=Size, Site and Clinical Incidence of Lipoma:Factors in the Differential Diagnosis of Lipoma and Sarcoma|journal=Acta Orthopaedica Scandinavica|volume=54|issue=6|year=2009|pages=929–934|issn=0001-6470|doi=10.3109/17453678308992936}}</ref><ref>{{cite book | last = Miettinen | first = Markku | title = Modern soft tissue pathology : tumors and non-neoplastic conditions | publisher = Cambridge University Press | location = Cambridge New York | year = 2010 | isbn = 9780521874090 }}</ref><ref name="PhalenKendrick1971">{{cite journal|last1=Phalen|first1=George S.|last2=Kendrick|first2=James I.|last3=Rodriguez|first3=Juan M.|title=Lipomas of the upper extremity|journal=The American Journal of Surgery|volume=121|issue=3|year=1971|pages=298–306|issn=00029610|doi=10.1016/0002-9610(71)90208-X}}</ref>
* It usually presents with a slowly growing [[soft tissue]] [[mass]], typically less than 10 cm.
*[[Trunk]], [[shoulder]], upper arm, and [[neck]] are the most commonly affected locations.
* They are completely [[benign]], but recurrence is one of the [[complications]].
*[[Malignant transformation]] is rarely reported.
* Recurrence is more common among deeply located lipomas, given the increased difficulty for complete removal.
==Complications==
==Complications==
The complications of lipoma listed below:
*The [[complications]] of lipoma listed below:<ref name="BancroftKransdorf2006">{{cite journal|last1=Bancroft|first1=Laura W.|last2=Kransdorf|first2=Mark J.|last3=Peterson|first3=Jeffrey J.|last4=O’Connor|first4=Mary I.|title=Benign fatty tumors: classification, clinical course, imaging appearance, and treatment|journal=Skeletal Radiology|volume=35|issue=10|year=2006|pages=719–733|issn=0364-2348|doi=10.1007/s00256-006-0189-y}}</ref>
* [[Bleeding]]
** Recurrence (<5%)
* [[Ulceration]]
** [[Malignant]] transformation (rarely reported)
* Malignant transformation
 
==Prognosis==
==Prognosis==
* Lipomas are rarely life-threatening and the common subcutaneous lipomas are not a serious condition. Lipomas growing in internal organs can be more dangerous. <ref>{{cite journal |author=Thompson WM |title=Imaging and findings of lipomas of the gastrointestinal tract |journal=AJR Am J Roentgenol |volume=184 |issue=4 |pages=1163–71 |date=1 April 2005|pmid=15788588 |url=http://www.ajronline.org/cgi/pmidlookup?view=long&pmid=15788588 |doi=10.2214/ajr.184.4.01841163}}</ref><ref>{{cite journal |author=Taylor AJ, Stewart ET, Dodds WJ |title=Gastrointestinal lipomas: a radiologic and pathologic review |journal=AJR Am J Roentgenol |volume=155 |issue=6 |pages=1205–10 |date=1 December 1990|pmid=2122666 |url=http://www.ajronline.org/cgi/pmidlookup?view=long&pmid=2122666 |doi=10.2214/ajr.155.6.2122666}}</ref>
*[[Prognosis]] is excellent. <ref name="BancroftKransdorf2006">{{cite journal|last1=Bancroft|first1=Laura W.|last2=Kransdorf|first2=Mark J.|last3=Peterson|first3=Jeffrey J.|last4=O’Connor|first4=Mary I.|title=Benign fatty tumors: classification, clinical course, imaging appearance, and treatment|journal=Skeletal Radiology|volume=35|issue=10|year=2006|pages=719–733|issn=0364-2348|doi=10.1007/s00256-006-0189-y}}</ref>
* Malignant transformation of lipomas into [[liposarcoma]]s is very rare and most liposarcomas are not produced from pre-existing benign lesions. A few cases of malignant transformation have been described for bone and kidney lipomas,<ref>{{cite journal |author=Milgram JW |title=Malignant transformation in bone lipomas |journal=Skeletal Radiol. |volume=19 |issue=5 |pages=347–52 |year=1990 |pmid=2165632 |doi=10.1007/BF00193088}}</ref><ref>{{cite journal |author=Lowe BA, Brewer J, Houghton DC, Jacobson E, Pitre T |title=Malignant transformation of angiomyolipoma |journal=J. Urol. |volume=147 |issue=5 |pages=1356–8 |date=May 1992 |pmid=1569683}}</ref> but it is possible these few reported cases were well-differentiated liposarcomas in which the subtle [[malignant]] characteristics were missed when the tumour was first examined.<ref name=Enzinger08>{{cite book |author=Goldblum, John R.; Weiss, Sharon W.; Enzinger, Franz M. |title=Enzinger and Weiss's soft tissue tumors |publisher=Mosby Elsevier |year=2008 |isbn=0-323-04628-2 |edition=5th}}</ref>  
* Lipomas are completely [[benign]].
* Deep lipomas have a greater tendency to recur than superficial lipomas, because complete surgical removal of deep lipomas is not always possible.<ref>{{cite book |author=Fletcher, C.D.M., Unni, K.K., Mertens, F. |title=Pathology and Genetics of Tumours of Soft Tissue and Bone |publisher=IARC Press |location=Lyon |year=2002 |isbn=92-832-2413-2 |series=World Health Organization Classification of Tumours |volume=4}}</ref>
 
==References==
==References==
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{{reflist|2}}
 
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Latest revision as of 16:09, 22 November 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Overview

Lipoma tends to affect individuals of 40 to 60 years of age. They are completely benign and recurrence is one of their complications.

Natural History

  • Lipoma usually affects individuals of 40 to 60 years of age.[1][2][3]
  • It usually presents with a slowly growing soft tissue mass, typically less than 10 cm.
  • Trunk, shoulder, upper arm, and neck are the most commonly affected locations.
  • They are completely benign, but recurrence is one of the complications.
  • Malignant transformation is rarely reported.
  • Recurrence is more common among deeply located lipomas, given the increased difficulty for complete removal.

Complications

Prognosis

References

  1. Rydholm, Anders; Berg, Nils O. (2009). "Size, Site and Clinical Incidence of Lipoma:Factors in the Differential Diagnosis of Lipoma and Sarcoma". Acta Orthopaedica Scandinavica. 54 (6): 929–934. doi:10.3109/17453678308992936. ISSN 0001-6470.
  2. Miettinen, Markku (2010). Modern soft tissue pathology : tumors and non-neoplastic conditions. Cambridge New York: Cambridge University Press. ISBN 9780521874090.
  3. Phalen, George S.; Kendrick, James I.; Rodriguez, Juan M. (1971). "Lipomas of the upper extremity". The American Journal of Surgery. 121 (3): 298–306. doi:10.1016/0002-9610(71)90208-X. ISSN 0002-9610.
  4. 4.0 4.1 Bancroft, Laura W.; Kransdorf, Mark J.; Peterson, Jeffrey J.; O’Connor, Mary I. (2006). "Benign fatty tumors: classification, clinical course, imaging appearance, and treatment". Skeletal Radiology. 35 (10): 719–733. doi:10.1007/s00256-006-0189-y. ISSN 0364-2348.