Fosamprenavir contraindications: Difference between revisions
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{{Fosamprenavir}} | {{Fosamprenavir}} | ||
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==Contraindications== | ==Contraindications== | ||
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LEXIVA is contraindicated: | LEXIVA is contraindicated: | ||
* | * In patients with previously demonstrated clinically significant [[hypersensitivity]] (e.g., [[Stevens-Johnson syndrome]]) to any of the components of this product or to amprenavir. | ||
* | * When coadministered with drugs that are highly dependent on [[cytochrome P450]] 3A4 (CYP3A4) for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events (Table 2).<ref>{{Cite web | last = | first = | title = LEXIVA (FOSAMPRENAVIR CALCIUM) TABLET, FILM COATED LEXIVA (FOSAMPRENAVIR CALCIUM) SUSPENSION [VIIV HEALTHCARE COMPANY] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=24feb9be-32a6-45fd-a896-f3e202edd8a9 | publisher = | date = | accessdate = }}</ref> | ||
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Latest revision as of 19:15, 5 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]
Contraindications
LEXIVA is contraindicated:
- In patients with previously demonstrated clinically significant hypersensitivity (e.g., Stevens-Johnson syndrome) to any of the components of this product or to amprenavir.
- When coadministered with drugs that are highly dependent on cytochrome P450 3A4 (CYP3A4) for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events (Table 2).[1]
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References
Adapted from the FDA Package Insert.