Gamma-glutamyl carboxylase: Difference between revisions
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Revision as of 17:47, 4 September 2012
gamma-glutamyl carboxylase | |
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Identifiers | |
Symbol | GGCX |
Entrez | 2677 |
HUGO | 4247 |
OMIM | 137167 |
RefSeq | NM_000821 |
UniProt | P38435 |
Other data | |
Locus | Chr. 2 p12 |
Gamma-glutamyl carboxylase is an enzyme which oxidizes Vitamin K hydroquinone to Vitamin K 2,3 epoxide, while simultaneously adding CO2 to protein-bound glutamic acid (abbreviation = Glu) to form gamma-carboxyglutamic acid (also called gamma-carboxyglutamate, abbreviation = Gla). The carboxylation reaction will only proceed if the carboxylase enzyme is able to oxidize vitamin K hydroquinone to vitamin K epoxide at the same time; the carboxylation and epoxidation reactions are said to be coupled reactions.[1][2] Gla domain-containing proteins depend on the carboxylation reaction for posttranslational modification.
References
Further reading
- David A. Bender, Nutritional biochemistry of the vitamins, Cambridge University Press, 2003
- G. F. M. Ball, Vitamins: their role in the human body, Blackwell Science, 2004
- Gerald F. Combs, The vitamins: fundamental aspects in nutrition and health, Academic Press, 1998
See also
External links
- glutamyl+carboxylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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