Fever of unknown origin history and symptoms: Difference between revisions
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| style="vertical-align: middle; padding: 5px;" align=center | [[File:Siren.gif|30px|link=Fever of unknown origin resident survival guide]] | | style="vertical-align: middle; padding: 5px;" align="center" |[[File:Siren.gif|30px|link=Fever of unknown origin resident survival guide]] | ||
| style="vertical-align: middle; padding: 5px;" align=center | [[Fever of unknown origin resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']] | | style="vertical-align: middle; padding: 5px;" align="center" |[[Fever of unknown origin resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']] | ||
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{{Fever of unknown origin}} | {{Fever of unknown origin}} | ||
{{CMG}} | {{CMG}} | ||
{{SK}} febris continua e causa ignota; febris e causa ignota; febris E.C.I.; | {{SK}} febris continua e causa ignota; febris e causa ignota; febris E.C.I.; fever/pyrexia of obscured/undetermined/uncertain/unidentifiable/unknown focus/origin/source; fever/pyrexia without a focus/origin/source; FUO; PUO | ||
==History== | |||
History is the most important step in making diagnosis of FUO, most important components of history are listed below:<ref name="pmid32462043">{{cite journal| author=Wright WF, Auwaerter PG| title=Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma. | journal=Open Forum Infect Dis | year= 2020 | volume= 7 | issue= 5 | pages= ofaa132 | pmid=32462043 | doi=10.1093/ofid/ofaa132 | pmc=7237822 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=32462043 }}</ref> | |||
===History of presenting illness=== | |||
Proper attention should made in documenting history of presenting illness which is mostly fever, duration of fever, pattern of fever, and associated symptoms may provide clues toward diagnosis and limit unnecessary investigations. | |||
===Past medical and surgical history=== | |||
Chronic medical illness such as [[tuberculosis]], [[SLE]] and other autoinflammatory conditions should be inquired as they may be the source of fever. Surgical history is important as post operative complications can cause fever. | |||
===Social History=== | |||
Social history is very important because diseases like [[infective endocarditis]] and [[osteomyelitis]] are common in drug abuser, [[Histoplasmosis]] is common in cave explorers, [[leptospirosis]] common in surfers, catch scratch disease and diseases caused by insects are common in people exposed to animals. Some diseases are endemic to certain places hence people should be inquired about their place of origin as all of the aforementioned diseases can be cause of FUO.<ref name="pmid22475734">{{cite journal| author=Hayakawa K, Ramasamy B, Chandrasekar PH| title=Fever of unknown origin: an evidence-based review. | journal=Am J Med Sci | year= 2012 | volume= 344 | issue= 4 | pages= 307-16 | pmid=22475734 | doi=10.1097/MAJ.0b013e31824ae504 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22475734 }}</ref> | |||
===Socioeconomic and Vaccination history=== | |||
Some diseases are limited to poor population due to malnutrition, decreased immunity and living in overcrowded places which increases the chances of contact with the disease source. Unvaccinated people are prone to certain diseases that may cause FUO. | |||
===Family history=== | |||
Genetics play important role in acquiring and response to disease. | |||
== Symptoms == | |||
Fever is the main symptom and proper attention should be given to the duration, frequency, magnitude, [[pattern of fever]] and associated symptoms as some fever patterns are very specific for some diseases and narrows down differential diagnosis.<ref name="pmid8698993">{{cite journal| author=Cunha BA| title=The clinical significance of fever patterns. | journal=Infect Dis Clin North Am | year= 1996 | volume= 10 | issue= 1 | pages= 33-44 | pmid=8698993 | doi=10.1016/s0891-5520(05)70284-1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8698993 }}</ref> | |||
Examples: | |||
# High magnitude and persistent fevers the most likely cause is infectious. | |||
# Relapsing fever the most likely causes are [[Borrelia burgdorferi]], [[Q fever]], [[Typhoid fever]], [[Brucellosis]], [[Leptospirosis]], [[Colorado tick fever]]. | |||
# Biphasic fever the most likely cause is [[African hemorrhagic fever]]. | |||
# Fever with relative bradycardia the most likely cause is [[legionnaires’ disease]] or drug fever. | |||
<br /> | |||
==References== | ==References== | ||
{{Reflist|2}} | |||
[[Category:Ailments of unknown etiology]] | |||
[[Category: | |||
Latest revision as of 23:26, 23 January 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: febris continua e causa ignota; febris e causa ignota; febris E.C.I.; fever/pyrexia of obscured/undetermined/uncertain/unidentifiable/unknown focus/origin/source; fever/pyrexia without a focus/origin/source; FUO; PUO
History
History is the most important step in making diagnosis of FUO, most important components of history are listed below:[1]
History of presenting illness
Proper attention should made in documenting history of presenting illness which is mostly fever, duration of fever, pattern of fever, and associated symptoms may provide clues toward diagnosis and limit unnecessary investigations.
Past medical and surgical history
Chronic medical illness such as tuberculosis, SLE and other autoinflammatory conditions should be inquired as they may be the source of fever. Surgical history is important as post operative complications can cause fever.
Social History
Social history is very important because diseases like infective endocarditis and osteomyelitis are common in drug abuser, Histoplasmosis is common in cave explorers, leptospirosis common in surfers, catch scratch disease and diseases caused by insects are common in people exposed to animals. Some diseases are endemic to certain places hence people should be inquired about their place of origin as all of the aforementioned diseases can be cause of FUO.[2]
Socioeconomic and Vaccination history
Some diseases are limited to poor population due to malnutrition, decreased immunity and living in overcrowded places which increases the chances of contact with the disease source. Unvaccinated people are prone to certain diseases that may cause FUO.
Family history
Genetics play important role in acquiring and response to disease.
Symptoms
Fever is the main symptom and proper attention should be given to the duration, frequency, magnitude, pattern of fever and associated symptoms as some fever patterns are very specific for some diseases and narrows down differential diagnosis.[3]
Examples:
- High magnitude and persistent fevers the most likely cause is infectious.
- Relapsing fever the most likely causes are Borrelia burgdorferi, Q fever, Typhoid fever, Brucellosis, Leptospirosis, Colorado tick fever.
- Biphasic fever the most likely cause is African hemorrhagic fever.
- Fever with relative bradycardia the most likely cause is legionnaires’ disease or drug fever.
References
- ↑ Wright WF, Auwaerter PG (2020). "Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma". Open Forum Infect Dis. 7 (5): ofaa132. doi:10.1093/ofid/ofaa132. PMC 7237822 Check
|pmc=value (help). PMID 32462043 Check|pmid=value (help). - ↑ Hayakawa K, Ramasamy B, Chandrasekar PH (2012). "Fever of unknown origin: an evidence-based review". Am J Med Sci. 344 (4): 307–16. doi:10.1097/MAJ.0b013e31824ae504. PMID 22475734.
- ↑ Cunha BA (1996). "The clinical significance of fever patterns". Infect Dis Clin North Am. 10 (1): 33–44. doi:10.1016/s0891-5520(05)70284-1. PMID 8698993.