Sandbox:mustafa

Diseases	Clinical manifestations			Para-clinical findings							Gold standard	Additional findings
	History		Physical examination
				Lab Findings			Imaging			Histopathology
	Etiology	Signs & Symptoms	Murmur Type	Physical exam 3	Lab 1	Lab 2	Lab 3	Imaging 1	Imaging 2				Imaging 3
Aortic Stenosis	Age-related calcification in the elderly Bicuspid aortic valve in the young leads to early calcification of the valve	Chest pain Dyspnea on exertion Palpitations Symptoms of heart failure	Systolic murmur crescendo-decrescendo murmur radiates to the carotids heard best at the base
Aortic Regurgitation	Aortic root dilatation Bicuspid aortic valve Endocarditis Rheumatic fever	Dyspnea on exertion Paroxysmal nocturnal dyspnea Orthopnea	Diastolic murmur early diastolic decrescendo murmur Austin Flint murmur apical diastolic rumbling Maneuvers ↑ murmur intensity hand grip rapid squatting
Mitral Stenosis	Rheumatic fever	Dyspnea on exertion Paroxysmal nocturnal dyspnea Orthopnea New onset atrial fibrillation	Diastolic murmur open snap (OS) and delayed rumbling mid-to-late diastolic murmur the time between A2 and OS is inversely correlated with severity
Mitral Regurgitation	Rheumatic fever Endocarditis Post-myocardial infarction rupture of the chordae or papillary muscles   Left ventricular dilatation	Palpitations Symptoms of heart failure in severe cases	Holosystolic murmur high-pitched and radiates towards the axilla heard best at the apex Maneuvers ↑ murmur intensity hand grip rapid squatting