Neonatal onset multisystem inflammatory disease: Difference between revisions

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#redirest [[Cryopyrin-associated periodic syndrome]]
 
 
==Overview==
'''Neonatal onset multisystem inflammatory disease''' (also known as '''NOMID''', '''Chronic Neurologic Cutaneous and Articular Syndrome''', or '''CINCA''') is a [[rare disease|rare]] genetic [[periodic fever syndrome]] which causes uncontrolled inflammation in multiple parts of the body starting in the newborn period. Symptoms include skin rashes, severe [[arthritis]], and chronic [[meningitis]] leading to neurologic damage.
 
NOMID can result from a mutation in the [[CIAS1]] gene, which helps control inflammation. Mutations in this gene also cause [[familial cold urticaria]] and [[Muckle-Wells syndrome]]. NOMID has been successfully treated with the drug [[anakinra]].
 
==References==
*{{OMIM|607115}}
* Goldbach-Mansky, R. et al. ''Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1{beta} Inhibition'' N Engl J Med 2006 355: 581-592.
 
 
 
[[Category:Rheumatology]]
 
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Latest revision as of 13:38, 30 July 2019