Neurofibroma natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
[[Prognosis]] of neurofibroma is generally excellent. If left untreated, 10% of patients with [[plexiform neurofibroma]]s may progress to develop [[malignant peripheral nerve sheath tumor]] (MPNST) | [[Prognosis]] of neurofibroma is generally excellent. If left untreated, 10% of patients with [[plexiform neurofibroma]]s may progress to develop [[malignant peripheral nerve sheath tumor]] (MPNST)<ref name="pmid12898075">{{cite journal |author=Mautner VF, Friedrich RE, von Deimling A, Hagel C, Korf B, Knöfel MT, Wenzel R, Fünsterer C. |title=Malignant peripheral nerve sheath tumours in neurofibromatosis type 1: MRI supports the diagnosis of malignant plexiform neurofibroma. |journal=American Journal of Pathology |volume=45 |issue=9 |pages=618–25 |year=2003 |pmid=12898075 |doi=10.1007/s00234-003-0964-6}}</ref> | ||
==Natural History== | ==Natural History== | ||
* If left untreated, 10% of patients with [[plexiform neurofibroma]]s may progress to develop [[malignant peripheral nerve sheath tumor]] (MPNST) | * If left untreated, 10% of patients with [[plexiform neurofibroma]]s may progress to develop [[malignant peripheral nerve sheath tumor]] (MPNST)<ref name="pmid12898075">{{cite journal |author=Mautner VF, Friedrich RE, von Deimling A, Hagel C, Korf B, Knöfel MT, Wenzel R, Fünsterer C. |title=Malignant peripheral nerve sheath tumours in neurofibromatosis type 1: MRI supports the diagnosis of malignant plexiform neurofibroma. |journal=American Journal of Pathology |volume=45 |issue=9 |pages=618–25 |year=2003 |pmid=12898075 |doi=10.1007/s00234-003-0964-6}}</ref> | ||
==Complications== | ==Complications== | ||
* [[Malignant transformation]]<ref name="pmid12898075">{{cite journal |author=Mautner VF, Friedrich RE, von Deimling A, Hagel C, Korf B, Knöfel MT, Wenzel R, Fünsterer C. |title=Malignant peripheral nerve sheath tumours in neurofibromatosis type 1: MRI supports the diagnosis of malignant plexiform neurofibroma. |journal=American Journal of Pathology |volume=45 |issue=9 |pages=618–25 |year=2003 |pmid=12898075 |doi=10.1007/s00234-003-0964-6}}</ref> | * [[Malignant transformation|Malignant transformation (plexiform neurofibroma)]]<ref name="pmid12898075">{{cite journal |author=Mautner VF, Friedrich RE, von Deimling A, Hagel C, Korf B, Knöfel MT, Wenzel R, Fünsterer C. |title=Malignant peripheral nerve sheath tumours in neurofibromatosis type 1: MRI supports the diagnosis of malignant plexiform neurofibroma. |journal=American Journal of Pathology |volume=45 |issue=9 |pages=618–25 |year=2003 |pmid=12898075 |doi=10.1007/s00234-003-0964-6}}</ref> | ||
* Local recurrence (rare) | |||
==Prognosis== | ==Prognosis== | ||
* [[Prognosis]] of neurofibroma is generally excellent | * [[Prognosis]] of neurofibroma is generally excellent | ||
==References== | ==References== | ||
Revision as of 14:04, 3 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Shanshan Cen, M.D. [3]
Overview
Prognosis of neurofibroma is generally excellent. If left untreated, 10% of patients with plexiform neurofibromas may progress to develop malignant peripheral nerve sheath tumor (MPNST)[1]
Natural History
- If left untreated, 10% of patients with plexiform neurofibromas may progress to develop malignant peripheral nerve sheath tumor (MPNST)[1]
Complications
- Malignant transformation (plexiform neurofibroma)[1]
- Local recurrence (rare)
Prognosis
- Prognosis of neurofibroma is generally excellent
References
- ↑ 1.0 1.1 1.2 Mautner VF, Friedrich RE, von Deimling A, Hagel C, Korf B, Knöfel MT, Wenzel R, Fünsterer C. (2003). "Malignant peripheral nerve sheath tumours in neurofibromatosis type 1: MRI supports the diagnosis of malignant plexiform neurofibroma". American Journal of Pathology. 45 (9): 618–25. doi:10.1007/s00234-003-0964-6. PMID 12898075.