Langerhans cell histiocytosis causes: Difference between revisions

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{{Langerhans cell histiocytosis}}
{{Langerhans cell histiocytosis}}
{{CMG}}
{{CMG}} {{AE}} {{HL}}
 
==Overview==
==Overview==
Histiocytosis X has typically been thought of as a cancer-like condition. More recently researchers have begun to suspect that it is actually an autoimmune phenomenon, in which immune cells mistakenly attack the body, rather than fight infections. Extra immune cells may form tumors, which can affect various parts of the body including the bones, skull, and other areas.
There are no established direct causes for Langerhans cell histiocytosis. Common [[genetic mutations]] involved in the development of Langerhans cell histiocytosis can be found [[Langerhans cell histiocytosis pathophysiology|'''here''']].
 
==Causes==
Some forms of the disorder are genetic.
There are no established direct causes for Langerhans cell histiocytosis. Common [[genetic mutations]] involved in the development of Langerhans cell histiocytosis can be found [[Langerhans cell histiocytosis pathophysiology|'''here''']].<ref name="pmid25281259">{{cite journal| author=DiCaprio MR, Roberts TT| title=Diagnosis and Management of Langerhans Cell Histiocytosis. | journal=J Am Acad Orthop Surg | year= 2014 | volume= 22 | issue= 10 | pages= 643-652 | pmid=25281259 | doi=10.5435/JAAOS-22-10-643 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25281259  }} </ref><ref name="pmid25310214">{{cite journal| author=Grana N| title=Langerhans cell histiocytosis. | journal=Cancer Control | year= 2014 | volume= 21 | issue= 4 | pages= 328-34 | pmid=25310214 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25310214  }} </ref><ref name="pmid26414464">{{cite journal| author=Harmon CM, Brown N| title=Langerhans Cell Histiocytosis: A Clinicopathologic Review and Molecular Pathogenetic Update. | journal=Arch Pathol Lab Med | year= 2015 | volume= 139 | issue= 10 | pages= 1211-4 | pmid=26414464 | doi=10.5858/arpa.2015-0199-RA | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26414464  }} </ref>
 
Histiocytosis X is thought to affect roughly 1 in 200,000 people each year. It is most often seen in children ages 1 to 15. The rate peaks among children ages 5 to10.
 
Pulmonary histiocytosis X is a specific type of this disorder that involves swelling of the small airways (bronchioles) and small blood vessels in the lungs. It is most common in adults. The inflammation leads to lung stiffening and damage. The cause is unknown. It most often affects those ages 30 to 40, usually cigarette smokers.
 
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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[[Category:Disease]]
[[Category:Disease]]
[[Category:Autoimmune diseases]]
[[Category:Autoimmune diseases]]
[[Category:Oncology]]
[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Up-To-Date]]
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[[Category:Medicine]]
[[Category:Dermatology]]
[[Category:Surgery]]

Latest revision as of 21:43, 23 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

There are no established direct causes for Langerhans cell histiocytosis. Common genetic mutations involved in the development of Langerhans cell histiocytosis can be found here.

Causes

There are no established direct causes for Langerhans cell histiocytosis. Common genetic mutations involved in the development of Langerhans cell histiocytosis can be found here.[1][2][3]

References

  1. DiCaprio MR, Roberts TT (2014). "Diagnosis and Management of Langerhans Cell Histiocytosis". J Am Acad Orthop Surg. 22 (10): 643–652. doi:10.5435/JAAOS-22-10-643. PMID 25281259.
  2. Grana N (2014). "Langerhans cell histiocytosis". Cancer Control. 21 (4): 328–34. PMID 25310214.
  3. Harmon CM, Brown N (2015). "Langerhans Cell Histiocytosis: A Clinicopathologic Review and Molecular Pathogenetic Update". Arch Pathol Lab Med. 139 (10): 1211–4. doi:10.5858/arpa.2015-0199-RA. PMID 26414464.


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