Chondrosarcoma classification: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
 
(38 intermediate revisions by 4 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Chondrosarcoma}}
{{Chondrosarcoma}}
{{CMG}}


{{CMG}}; {{AE}} {{Rohan}}
==Overview==
Chondrosarcoma may be classified based on histological findings and location.
==Classification==
==Classification==
===Classification and Grading===
*Chondrosarcoma be classified based on [[Histology|histological findings]] and location.
Physicians grade chondrosarcoma using several criteria, but particularly on how abnormal the cancerous cells appear under the microscope, and the growth rate of the tumors themselves, both of which are directly linked to the propensity of the cancer to invade locally, and to spread widely to distant organs and sites in the body (called [[metastasis]]).


====Grade 1====
===Histological Classification===
Chondrosarcoma grows relatively slowly, has cells whose [[histological]] appearance is quite similar to cells of normal cartilage
*Chondrosarcoma may be classified based on [[Histological|histological findings]] into following groups:<ref name="pmid8378694">{{cite journal| author=Raymond E, L'Her P, Jeanbourquin D, Schill H, Jancovici R, Daly JP et al.| title=[Chondrosarcoma of the thoracic wall. Review of the literature apropos of 4 cases]. | journal=Rev Pneumol Clin | year= 1993 | volume= 49 | issue= 1 | pages= 19-25 | pmid=8378694 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8378694  }} </ref><ref name="pmid30559960">{{cite journal| author=Lex JR, Evans S, Stevenson JD, Parry M, Jeys LM, Grimer RJ| title=Dedifferentiated chondrosarcoma of the pelvis: clinical outcomes and current treatment. | journal=Clin Sarcoma Res | year= 2018 | volume= 8 | issue= | pages= 23 | pmid=30559960 | doi=10.1186/s13569-018-0110-1 | pmc=6293503 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30559960  }} </ref>
Have much less aggressive invasive and metastatic properties.  
====Grades 2 and 3====
*These grades are increasingly faster-growing cancers, with more varied and abnormal-looking cells.
*These are much more likely to infiltrate surrounding tissues, [[lymph nodes]], and organs.
====Grade 4====
*Some, but not all, authorities and medical facilities assign a "Grade 4" to the most [[anaplastic]], undifferentiated cartilage-derived tumors.


[[ICD-O]] codes provide a more precise classification of chondrosarcoma. These "subtypes" are derived from, and reflect, both
'''Primary Chondrosarcoma'''
(a) The topographical location of the tumor
*Chondrosarcoma that arises denovo and comprises of following subtypes:
(b) The histological characteristics of the cancerous cartilage cells
**Conventional chondrosarcoma - Low-grade, high-grade, and dedifferentiated chondrosarcoma (90% of all chondrosarcomas)
(c) The makeup of the surrounding matrix material associated with the tumor
**Clear cell chondrosarcoma (1% of all chondrosarcomas)
**Mesenchymal chondrosarcoma (2% of all chondrosarcomas)


* 9220 = Chondrosarcoma NOS ("Not Otherwise Specified")
'''Secondary Chondrosarcoma'''
* 9221 = Juxtacortical chondrosarcoma
*Chondrosarcoma that arises from [[benign]] [[cartilage]] lesions includes (7% of all chondrosarcomas):
* 9231 = Myxoid chondrosarcoma
**[[Osteochondroma]] (<1% risk of [[malignant]] transfomation)
* 9240 = Mesenchymal chondrosarcoma
**Multiple hereditary exostosis (1-10% risk of [[malignant]] transformation)
* 9242 = Clear cell chondrosarcoma
**[[Enchondroma|Enchondromas]] (1% risk of [[malignant]] transformation)
* 9243 = Dedifferentiated chondrosarcoma
**[[Enchondroma|Ollier's disease]] (25-40% risk of [[malignant]] transformation)
**[[Maffucci's disease]](100% risk of [[malignant]] transformation)


===Based on Location===
*Chondrosarcoma may be classified based on location into following groups:<ref name="pmid19411454">{{cite journal| author=Giuffrida AY, Burgueno JE, Koniaris LG, Gutierrez JC, Duncan R, Scully SP| title=Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database. | journal=J Bone Joint Surg Am | year= 2009 | volume= 91 | issue= 5 | pages= 1063-72 | pmid=19411454 | doi=10.2106/JBJS.H.00416 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19411454  }} </ref><ref name="pmid17908885">{{cite journal| author=Skeletal Lesions Interobserver Correlation among Expert Diagnosticians (SLICED) Study Group| title=Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones. | journal=J Bone Joint Surg Am | year= 2007 | volume= 89 | issue= 10 | pages= 2113-23 | pmid=17908885 | doi=10.2106/JBJS.F.01530 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17908885  }} </ref>
**Centrally located within the [[medullary cavity]]. (central chondrosarcoma) (70% of all chondrosarcomas)
**Peripherally located on the surface of bone as a result of [[malignant]] transformation within the [[cartilaginous]] cap. (Peripheral chondrosarcoma) (15% of all chondrosarcomas)


==References==
==References==
{{reflist|2}}
{{Reflist|2}}
[[Category:Disease]]
{{WH}}
{{WS}}
 
[[Category:Up-To-Date]]
[[Category:Orthopedics]]
[[Category:Orthopedics]]
[[Category:Types of cancer]]
[[Category:Oncology]]
[[Category:Skeletal disorders]]
[[Category:Medicine]]
 
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}

Latest revision as of 15:52, 24 January 2019

Chondrosarcoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Chondrosarcoma from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

Echocardiography and Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Chondrosarcoma classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Chondrosarcoma classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Chondrosarcoma classification

CDC on Chondrosarcoma classification

Chondrosarcoma classification in the news

Blogs on Chondrosarcoma classification

Directions to Hospitals Treating Chondrosarcoma

Risk calculators and risk factors for Chondrosarcoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rohan A. Bhimani, M.B.B.S., D.N.B., M.Ch.[2]

Overview

Chondrosarcoma may be classified based on histological findings and location.

Classification

Histological Classification

Primary Chondrosarcoma

  • Chondrosarcoma that arises denovo and comprises of following subtypes:
    • Conventional chondrosarcoma - Low-grade, high-grade, and dedifferentiated chondrosarcoma (90% of all chondrosarcomas)
    • Clear cell chondrosarcoma (1% of all chondrosarcomas)
    • Mesenchymal chondrosarcoma (2% of all chondrosarcomas)

Secondary Chondrosarcoma

Based on Location

  • Chondrosarcoma may be classified based on location into following groups:[3][4]
    • Centrally located within the medullary cavity. (central chondrosarcoma) (70% of all chondrosarcomas)
    • Peripherally located on the surface of bone as a result of malignant transformation within the cartilaginous cap. (Peripheral chondrosarcoma) (15% of all chondrosarcomas)

References

  1. Raymond E, L'Her P, Jeanbourquin D, Schill H, Jancovici R, Daly JP; et al. (1993). "[Chondrosarcoma of the thoracic wall. Review of the literature apropos of 4 cases]". Rev Pneumol Clin. 49 (1): 19–25. PMID 8378694.
  2. Lex JR, Evans S, Stevenson JD, Parry M, Jeys LM, Grimer RJ (2018). "Dedifferentiated chondrosarcoma of the pelvis: clinical outcomes and current treatment". Clin Sarcoma Res. 8: 23. doi:10.1186/s13569-018-0110-1. PMC 6293503. PMID 30559960.
  3. Giuffrida AY, Burgueno JE, Koniaris LG, Gutierrez JC, Duncan R, Scully SP (2009). "Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database". J Bone Joint Surg Am. 91 (5): 1063–72. doi:10.2106/JBJS.H.00416. PMID 19411454.
  4. Skeletal Lesions Interobserver Correlation among Expert Diagnosticians (SLICED) Study Group (2007). "Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones". J Bone Joint Surg Am. 89 (10): 2113–23. doi:10.2106/JBJS.F.01530. PMID 17908885.

Template:WH Template:WS