PITPNM1: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Membrane-associated phosphatidylinositol transfer protein 1''' is a [[protein]] that in humans is encoded by the ''PITPNM1'' [[gene]].<ref name="pmid9680295">{{cite journal | vauthors = Rubboli F, Bulfone A, Bogni S, Marchitiello A, Zollo M, Borsani G, Ballabio A, Banfi S | title = A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms | journal = Genes Funct. | volume = 1 | issue = 3 | pages = 205–13 | year = 1997 | date = Aug 1998 | pmid = 9680295 | pmc =  | doi = 10.1046/j.1365-4624.1997.00015.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9600| accessdate = }}</ref>
'''Membrane-associated phosphatidylinositol transfer protein 1''' is a [[protein]] that in humans is encoded by the ''PITPNM1'' [[gene]].<ref name="pmid9680295">{{cite journal | vauthors = Rubboli F, Bulfone A, Bogni S, Marchitiello A, Zollo M, Borsani G, Ballabio A, Banfi S | title = A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms | journal = Genes Funct. | volume = 1 | issue = 3 | pages = 205–13 | year = 1997 | pmid = 9680295 | pmc =  | doi = 10.1046/j.1365-4624.1997.00015.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9600| accessdate = }}</ref>


== Function ==
== Function ==
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* {{cite journal | vauthors = Vihtelic TS, Hyde DR, O'Tousa JE | title = Isolation and characterization of the Drosophila retinal degeneration B (rdgB) gene | journal = Genetics | volume = 127 | issue = 4 | pages = 761–8 | year = 1991 | pmid = 1903119 | pmc = 1204403 | doi =  }}
* {{cite journal | vauthors = Vihtelic TS, Hyde DR, O'Tousa JE | title = Isolation and characterization of the Drosophila retinal degeneration B (rdgB) gene | journal = Genetics | volume = 127 | issue = 4 | pages = 761–8 | year = 1991 | pmid = 1903119 | pmc = 1204403 | doi =  }}
* {{cite journal | vauthors = Aikawa Y, Hara H, Watanabe T | title = Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene | journal = Biochem. Biophys. Res. Commun. | volume = 236 | issue = 3 | pages = 559–64 | year = 1997 | pmid = 9245688 | doi = 10.1006/bbrc.1997.7009 }}
* {{cite journal | vauthors = Aikawa Y, Hara H, Watanabe T | title = Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene | journal = Biochem. Biophys. Res. Commun. | volume = 236 | issue = 3 | pages = 559–64 | year = 1997 | pmid = 9245688 | doi = 10.1006/bbrc.1997.7009 }}
* {{cite journal | vauthors = Lev S, Hernandez J, Martinez R, Chen A, Plowman G, Schlessinger J | title = Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein | journal = Mol. Cell. Biol. | volume = 19 | issue = 3 | pages = 2278–88 | year = 1999 | pmid = 10022914 | pmc = 84020 | doi =  10.1128/mcb.19.3.2278}}
* {{cite journal | vauthors = Tian D, Litvak V, Toledo-Rodriguez M, Carmon S, Lev S | title = Nir2, a novel regulator of cell morphogenesis | journal = Mol. Cell. Biol. | volume = 22 | issue = 8 | pages = 2650–62 | year = 2002 | pmid = 11909959 | pmc = 133726 | doi = 10.1128/MCB.22.8.2650-2662.2002 }}
* {{cite journal | vauthors = Tian D, Litvak V, Toledo-Rodriguez M, Carmon S, Lev S | title = Nir2, a novel regulator of cell morphogenesis | journal = Mol. Cell. Biol. | volume = 22 | issue = 8 | pages = 2650–62 | year = 2002 | pmid = 11909959 | pmc = 133726 | doi = 10.1128/MCB.22.8.2650-2662.2002 }}
* {{cite journal | vauthors = Litvak V, Tian D, Carmon S, Lev S | title = Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis | journal = Mol. Cell. Biol. | volume = 22 | issue = 14 | pages = 5064–75 | year = 2002 | pmid = 12077336 | pmc = 139767 | doi = 10.1128/MCB.22.14.5064-5075.2002 }}
* {{cite journal | vauthors = Litvak V, Tian D, Carmon S, Lev S | title = Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis | journal = Mol. Cell. Biol. | volume = 22 | issue = 14 | pages = 5064–75 | year = 2002 | pmid = 12077336 | pmc = 139767 | doi = 10.1128/MCB.22.14.5064-5075.2002 }}

Latest revision as of 10:48, 15 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Membrane-associated phosphatidylinositol transfer protein 1 is a protein that in humans is encoded by the PITPNM1 gene.[1][2]

Function

PITPNM1 belongs to a family of proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein.[supplied by OMIM][2]

It was found that aggressive metastasized cancer cells produced more of the PITPNC1 protein. In contrast, tumor cells that had not spread had lower expression of PITPNC1. Studies reveal that PITPNC1 promotes malignant secretion by binding Golgi-resident PI4P and localizing RAB1B to the Golgi. RAB1B localization to the Golgi allows for the recruitment of GOLPH3 (Golgi phosphoprotein 3), which facilitates Golgi extension and enhanced vesicular release. PITPNC1-mediated vesicular release drives metastasis by increasing the secretion of pro-invasive and pro-angiogenic mediators HTRA1, MMP1, FAM3C, PDGFA, and ADAM10.[3]

Interactions

PITPNM1 has been shown to interact with PTK2B.[4]

References

  1. Rubboli F, Bulfone A, Bogni S, Marchitiello A, Zollo M, Borsani G, Ballabio A, Banfi S (1997). "A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms". Genes Funct. 1 (3): 205–13. doi:10.1046/j.1365-4624.1997.00015.x. PMID 9680295.
  2. 2.0 2.1 "Entrez Gene: PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1".
  3. Halberg N, Sengelaub CA, Navrazhina K, Molina H, Uryu K, Tavazoie SF (2016). "PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion". Cancer Cell. 29 (3): 339–353. doi:10.1016/j.ccell.2016.02.013. PMID 26977884.
  4. Lev S, Hernandez J, Martinez R, Chen A, Plowman G, Schlessinger J (Mar 1999). "Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein". Mol. Cell. Biol. 19 (3): 2278–88. doi:10.1128/mcb.19.3.2278. PMC 84020. PMID 10022914.

Further reading