FAM3C

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	Wikidata
View/Edit Human

Protein FAM3C is a protein that in humans is encoded by the FAM3C gene.^[1]^[2]

Function

This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. Alternate transcriptional splice variants which encode the same protein have been characterized.^[2] FAM3C functions and expression also were studied in mammalian brains^[3]^[4] which shown that a reduced FAM3C level associated to the onset of sporadic Alzheimer's disease (AD), which highlighted FAM3C as a promising therapeutic target for Alzheimer's disease. Moreover, level of FAM3C was claimed to be a biomarker for AD together with saponin D.^[5]

References

↑ Zhu Y, Xu G, Patel A, McLaughlin MM, Silverman C, Knecht K, Sweitzer S, Li X, McDonnell P, Mirabile R, Zimmerman D, Boyce R, Tierney LA, Hu E, Livi GP, Wolf B, Abdel-Meguid SS, Rose GD, Aurora R, Hensley P, Briggs M, Young PR (August 2002). "Cloning, expression, and initial characterization of a novel cytokine-like gene family". Genomics. 80 (2): 144–50. doi:10.1006/geno.2002.6816. PMID 12160727.
↑ ^2.0 ^2.1 "Entrez Gene: FAM3C family with sequence similarity 3, member C".
↑ Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M (June 2014). "The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor". Nature Communications. 5: 3917. doi:10.1038/ncomms4917. PMID 24894631.
↑ Liu L, Watanabe N, Akatsu H, Nishimura M (August 2016). "Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease". Neuroscience. 330: 236–46. doi:10.1016/j.neuroscience.2016.05.050. PMID 27256505.
↑ [1], Davies, Huw Alun; Kaj Blennow & James Norton McGuire, "Saposin D and FAM3C are biomarkers for alzheimer's disease"

"Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. November 1998. doi:10.1101/gr.8.11.1097. PMID 9847074.
Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM (July 2004). "Lineage-specific gene duplication and loss in human and great ape evolution". PLoS Biology. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.
Mauri P, Scarpa A, Nascimbeni AC, Benazzi L, Parmagnani E, Mafficini A, Della Peruta M, Bassi C, Miyazaki K, Sorio C (July 2005). "Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology: a strategy for identification of novel cancer markers". FASEB Journal. 19 (9): 1125–7. doi:10.1096/fj.04-3000fje. PMID 15985535.
Grønborg M, Kristiansen TZ, Iwahori A, Chang R, Reddy R, Sato N, Molina H, Jensen ON, Hruban RH, Goggins MG, Maitra A, Pandey A (January 2006). "Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach". Molecular & Cellular Proteomics. 5 (1): 157–71. doi:10.1074/mcp.M500178-MCP200. PMID 16215274.
Guo J, Cheng H, Zhao S, Yu L (January 2006). "GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases". FEBS Letters. 580 (2): 581–4. doi:10.1016/j.febslet.2005.12.076. PMID 16406369.
Waerner T, Alacakaptan M, Tamir I, Oberauer R, Gal A, Brabletz T, Schreiber M, Jechlinger M, Beug H (September 2006). "ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells". Cancer Cell. 10 (3): 227–39. doi:10.1016/j.ccr.2006.07.020. PMID 16959614.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[pmid12160727-1] Zhu Y, Xu G, Patel A, McLaughlin MM, Silverman C, Knecht K, Sweitzer S, Li X, McDonnell P, Mirabile R, Zimmerman D, Boyce R, Tierney LA, Hu E, Livi GP, Wolf B, Abdel-Meguid SS, Rose GD, Aurora R, Hensley P, Briggs M, Young PR (August 2002). "Cloning, expression, and initial characterization of a novel cytokine-like gene family". Genomics. 80 (2): 144–50. doi:10.1006/geno.2002.6816. PMID 12160727.

[entrez-2] 2.0 ^2.1 "Entrez Gene: FAM3C family with sequence similarity 3, member C".

[3] Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M (June 2014). "The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor". Nature Communications. 5: 3917. doi:10.1038/ncomms4917. PMID 24894631.

[4] Liu L, Watanabe N, Akatsu H, Nishimura M (August 2016). "Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease". Neuroscience. 330: 236–46. doi:10.1016/j.neuroscience.2016.05.050. PMID 27256505.

[5] [1], Davies, Huw Alun; Kaj Blennow & James Norton McGuire, "Saposin D and FAM3C are biomarkers for alzheimer's disease"

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FAM3C

Function

References

Further reading

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