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*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal  |vauthors=Yuryev A, Ono M, Goff SA, etal |title=Isoform-specific localization of A-RAF in mitochondria. |journal=Mol. Cell. Biol. |volume=20 |issue= 13 |pages= 4870–8 |year= 2000 |pmid= 10848612 |doi=  10.1128/MCB.20.13.4870-4878.2000| pmc=85938  }}
*{{cite journal  |vauthors=Yuryev A, Ono M, Goff SA, etal |title=Isoform-specific localization of A-RAF in mitochondria. |journal=Mol. Cell. Biol. |volume=20 |issue= 13 |pages= 4870–8 |year= 2000 |pmid= 10848612 |doi=  10.1128/MCB.20.13.4870-4878.2000| pmc=85938  }}
*{{cite journal  |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D }}
*{{cite journal  |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=  10.1017/S1355838202021088| pmc=1370266  }}
*{{cite journal  |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=  10.1017/S1355838202021088| pmc=1370266  }}
*{{cite journal  |vauthors=Zhao Y, Goto K, Saitoh M, etal |title=Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 30031–9 |year= 2002 |pmid= 12039962 |doi= 10.1074/jbc.M203811200 }}
*{{cite journal  |vauthors=Zhao Y, Goto K, Saitoh M, etal |title=Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 30031–9 |year= 2002 |pmid= 12039962 |doi= 10.1074/jbc.M203811200 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Yuryev A, Wennogle LP |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. |journal=Genomics |volume=81 |issue= 2 |pages= 112–25 |year= 2003 |pmid= 12620389 |doi=10.1016/S0888-7543(02)00008-3  }}
*{{cite journal  |vauthors=Yuryev A, Wennogle LP |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. |journal=Genomics |volume=81 |issue= 2 |pages= 112–25 |year= 2003 |pmid= 12620389 |doi=10.1016/S0888-7543(02)00008-3  }}
*{{cite journal  |vauthors=Goto K, Zhao Y, Saito M, etal |title=Activation function-1 domain of androgen receptor contributes to the interaction between two distinct subnuclear compartments. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2-5 |pages= 201–8 |year= 2003 |pmid= 12943705 |doi=10.1016/S0960-0760(03)00196-1  }}
*{{cite journal  |vauthors=Goto K, Zhao Y, Saito M, etal |title=Activation function-1 domain of androgen receptor contributes to the interaction between two distinct subnuclear compartments. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2-5 |pages= 201–8 |year= 2003 |pmid= 12943705 |doi=10.1016/S0960-0760(03)00196-1  }}

Latest revision as of 07:16, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.[1][2][3]

The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.[3]

Interactions

PRPF6 has been shown to interact with TXNL4B,[4] ARAF[5][6] and Androgen receptor.[7]

References

  1. Nishikimi A, Mukai J, Kioka N, Yamada M (January 2000). "A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors". Biochim Biophys Acta. 1435 (1–2): 147–52. doi:10.1016/s0167-4838(99)00203-4. PMID 10561546.
  2. Makarov EM, Makarova OV, Achsel T, Luhrmann R (June 2000). "The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions". J Mol Biol. 298 (4): 567–75. doi:10.1006/jmbi.2000.3685. PMID 10788320.
  3. 3.0 3.1 "Entrez Gene: PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)".
  4. Sun, Xiaojing; Zhang Hua; Wang Dan; Ma Dalong; Shen Yan; Shang Yongfeng (July 2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J. Biol. Chem. United States. 279 (31): 32839–47. doi:10.1074/jbc.M402522200. ISSN 0021-9258. PMID 15161931.
  5. Yuryev, Anton; Wennogle Lawrence P (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. United States. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN 0888-7543. PMID 12620389.
  6. Yuryev, A; Ono M; Goff S A; Macaluso F; Wennogle L P (July 2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. UNITED STATES. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. ISSN 0270-7306. PMC 85938. PMID 10848612.
  7. Zhao, Yue; Goto Kiminobu; Saitoh Masayuki; Yanase Toshihiko; Nomura Masatoshi; Okabe Taijiro; Takayanagi Ryoichi; Nawata Hajime (August 2002). "Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. Biol. Chem. United States. 277 (33): 30031–9. doi:10.1074/jbc.M203811200. ISSN 0021-9258. PMID 12039962.

Further reading

External links