Wilms' tumor laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
The lab studies conducted in patients suspected with | The lab studies conducted in patients suspected with Wilms tumor are [[Complete blood count]] (CBC), coagulation studies, [[Urinalysis]], [[Liver function tests|liver function test]], serum [[creatinine]], serum [[calcium]] and [[Cytogenetics]] studies. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
*The following lab studies are conducted in patients suspected with | *The following lab studies are conducted in patients suspected with Wilms tumor: | ||
**[[Complete blood count]] (CBC) | **[[Complete blood count]] (CBC) | ||
**Coagulation studies | **Coagulation studies | ||
***Von Willebrand assay | ***[[Von Willebrand's|von Willebrand assay]] | ||
**** | ****Should be performed in children with history of vascular diseases or [[bleeding]]. | ||
****Acquired [[Von Willebrand disease|Von Willebrand's disease]] can be present in patients suffering from | ****Acquired [[Von Willebrand disease|Von Willebrand's disease]] can be present in patients suffering from Wilms tumor.<ref name="pmid1311024">{{cite journal |vauthors=Coppes MJ, Zandvoort SW, Sparling CR, Poon AO, Weitzman S, Blanchette VS |title=Acquired von Willebrand disease in Wilms' tumor patients |journal=J. Clin. Oncol. |volume=10 |issue=3 |pages=422–7 |date=March 1992 |pmid=1311024 |doi=10.1200/JCO.1992.10.3.422 |url=}}</ref> | ||
****This is done as a precaution to risk of bleeding that can occur in case of interventions done for | ****This is done as a precaution to risk of [[bleeding]] that can occur in case of interventions done for Wilms tumor. | ||
**[[Urinalysis]] | **[[Urinalysis]] | ||
**[[Liver function tests|Liver function test]] | **[[Liver function tests|Liver function test]] | ||
***Abnormal in case of liver metastasis of | ***Abnormal in case of liver [[metastasis]] of Wilms tumor. | ||
**Serum [[creatinine]] | **Serum [[creatinine]] | ||
*** | ***Should be performed before and after surgical intervention. | ||
**Serum [[calcium]]<ref name="pmid2827881">{{cite journal |vauthors=Jayabose S, Iqbal K, Newman L, San Filippo JA, Davidian MM, Noto R, Sagel I |title=Hypercalcemia in childhood renal tumors |journal=Cancer |volume=61 |issue=4 |pages=788–91 |date=February 1988 |pmid=2827881 |doi= |url=}}</ref> | **Serum [[calcium]]<ref name="pmid2827881">{{cite journal |vauthors=Jayabose S, Iqbal K, Newman L, San Filippo JA, Davidian MM, Noto R, Sagel I |title=Hypercalcemia in childhood renal tumors |journal=Cancer |volume=61 |issue=4 |pages=788–91 |date=February 1988 |pmid=2827881 |doi= |url=}}</ref> | ||
***May be elevated in children suffering from rhabdoid tumor of kidney. | ***May be elevated in children suffering from [[Malignant rhabdoid tumor|rhabdoid tumor]] of kidney. | ||
***May be elevated in children suffering from congenital [[mesoblastic nephroma]]. | ***May be elevated in children suffering from congenital [[mesoblastic nephroma]]. | ||
**[[Cytogenetics]] studies | **[[Cytogenetics]] studies | ||
Latest revision as of 14:59, 16 July 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sargun Singh Walia M.B.B.S.[2]
Overview
The lab studies conducted in patients suspected with Wilms tumor are Complete blood count (CBC), coagulation studies, Urinalysis, liver function test, serum creatinine, serum calcium and Cytogenetics studies.
Laboratory Findings
- The following lab studies are conducted in patients suspected with Wilms tumor:
- Complete blood count (CBC)
- Coagulation studies
- von Willebrand assay
- Should be performed in children with history of vascular diseases or bleeding.
- Acquired Von Willebrand's disease can be present in patients suffering from Wilms tumor.[1]
- This is done as a precaution to risk of bleeding that can occur in case of interventions done for Wilms tumor.
- von Willebrand assay
- Urinalysis
- Liver function test
- Abnormal in case of liver metastasis of Wilms tumor.
- Serum creatinine
- Should be performed before and after surgical intervention.
- Serum calcium[2]
- May be elevated in children suffering from rhabdoid tumor of kidney.
- May be elevated in children suffering from congenital mesoblastic nephroma.
- Cytogenetics studies
References
- ↑ Coppes MJ, Zandvoort SW, Sparling CR, Poon AO, Weitzman S, Blanchette VS (March 1992). "Acquired von Willebrand disease in Wilms' tumor patients". J. Clin. Oncol. 10 (3): 422–7. doi:10.1200/JCO.1992.10.3.422. PMID 1311024.
- ↑ Jayabose S, Iqbal K, Newman L, San Filippo JA, Davidian MM, Noto R, Sagel I (February 1988). "Hypercalcemia in childhood renal tumors". Cancer. 61 (4): 788–91. PMID 2827881.