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{{Lung cancer}}
{{Lung cancer}}


{{CMG}}; {{AE}} {{SH}} {{KSH}} {{CZ}}  
{{CMG}}; {{AE}} {{KSH}} {{CZ}} {{SH}}


==Overview==
==Overview==
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==Causes==
==Causes==


*The direct cause of lung cancers is DNA mutations that often result in either activation of proto-oncogenes (e.g. '''K-RAS''') or the inactivation of tumors suppressor genes (e.g. '''TP53''') or both.
*The direct cause of lung cancers is DNA mutations that often result in either activation of proto-oncogenes (e.g. '''[[KRAS|K-RAS]]''') or the inactivation of [[Tumor suppressor gene|tumors suppressor genes]] (e.g. '''[[TP53]]''') or both.
*The risk of these genetic [[Mutation|mutations]] may be increased following exposure to environmental components, which are regarded as risk factors that predispose to the development of lung cancer.
*The risk of these genetic [[Mutation|mutations]] may be increased following exposure to environmental components, which are regarded as risk factors that predispose to the development of lung cancer.



Revision as of 16:03, 9 February 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kim-Son H. Nguyen M.D. Cafer Zorkun, M.D., Ph.D. [2] Dildar Hussain, MBBS [3]

Overview

The direct cause of lung cancers is DNA mutations that often result in either activation of proto-oncogenes (e.g. K-RAS) or the inactivation of tumors suppressor genes (e.g. TP53) or both. The risk of these genetic mutations may be increased following exposure to environmental components.

Causes

  • The direct cause of lung cancers is DNA mutations that often result in either activation of proto-oncogenes (e.g. K-RAS) or the inactivation of tumors suppressor genes (e.g. TP53) or both.
  • The risk of these genetic mutations may be increased following exposure to environmental components, which are regarded as risk factors that predispose to the development of lung cancer.
  • To view a comprehensive list of risk factors that increase the risk of lung cancer, click here

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