DAPK3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Death-associated protein kinase 3''' is an [[enzyme]] that in humans is encoded by the ''DAPK3'' [[gene]].<ref name="pmid9488481">{{cite journal | vauthors = Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S | title = ZIP kinase, a novel serine/threonine kinase which mediates apoptosis | journal = Molecular and Cellular Biology | volume = 18 | issue = 3 | pages = 1642–51 | date = Mar 1998 | pmid = 9488481 | pmc = 108879 | doi = 10.1128/mcb.18.3.1642}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DAPK3 death-associated protein kinase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1613| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_DAPK3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yrp.
| PDB = {{PDB2|1yrp}}, {{PDB2|2j90}}
| Name = Death-associated protein kinase 3
| HGNCid = 2676
| Symbol = DAPK3
| AltSymbols =; FLJ36473; ZIP; ZIPK
| OMIM = 603289
| ECnumber = 
| Homologene = 20353
| MGIid = 1203520
| GeneAtlas_image1 = PBB_GE_DAPK3_203891_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1613
    | Hs_Ensembl = ENSG00000167657
    | Hs_RefseqProtein = NP_001339
    | Hs_RefseqmRNA = NM_001348
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 3909454
    | Hs_GenLoc_end = 3922038
    | Hs_Uniprot = O43293
    | Mm_EntrezGene = 13144
    | Mm_Ensembl = ENSMUSG00000034974
    | Mm_RefseqmRNA = NM_007828
    | Mm_RefseqProtein = NP_031854
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 80587134
    | Mm_GenLoc_end = 80596127
    | Mm_Uniprot = Q05A21
  }}
}}
'''Death-associated protein kinase 3''', also known as '''DAPK3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DAPK3 death-associated protein kinase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1613| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Death-associated protein kinase 3 (DAPK3) induces [[morphology (biology)|morphological]] changes in [[apoptosis]] when overexpressed in mammalian cells.  These results suggest that DAPK3 may play a role in the induction of apoptosis.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells.  These results suggest that DAPK3 may play a role in the induction of apoptosis.<ref name="entrez">{{cite web | title = Entrez Gene: DAPK3 death-associated protein kinase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1613| accessdate = }}</ref>
}}


==References==
Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.<ref name="pmid17953487">{{cite journal | vauthors = Shoval Y, Pietrokovski S, Kimchi A | title = ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene | journal = PLoS Genetics | volume = 3 | issue = 10 | pages = 1884–93 | date = Oct 2007 | pmid = 17953487 | pmc = 2041995 | doi = 10.1371/journal.pgen.0030180 }}</ref>
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
DAPK3 has been shown to [[Protein-protein interaction|interact]] with [[PAWR]]<ref name="pmid12917339">{{cite journal | vauthors = Kawai T, Akira S, Reed JC | title = ZIP kinase triggers apoptosis from nuclear PML oncogenic domains | journal = Molecular and Cellular Biology | volume = 23 | issue = 17 | pages = 6174–86 | date = Sep 2003 | pmid = 12917339 | pmc = 180930 | doi = 10.1128/MCB.23.17.6174-6186.2003 }}</ref> and [[Death associated protein 6]].<ref name=pmid12917339/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Saito T, Seki N, Ohira M, Hayashi A, Kozuma S, Hattori A, Hori T | title = Assignment of the ZIP kinase gene to human chromosome 19p13.3 by somatic hybrid analysis and fluorescence in-situ hybridization | journal = Journal of Human Genetics | volume = 43 | issue = 3 | pages = 209–11 | year = 1998 | pmid = 9747039 | doi = 10.1007/s100380050073 }}
| citations =
* {{cite journal | vauthors = Murata-Hori M, Suizu F, Iwasaki T, Kikuchi A, Hosoya H | title = ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells | journal = FEBS Letters | volume = 451 | issue = 1 | pages = 81–4 | date = May 1999 | pmid = 10356987 | doi = 10.1016/S0014-5793(99)00550-5 }}
*{{cite journal | author=Kawai T, Matsumoto M, Takeda K, ''et al.'' |title=ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. |journal=Mol. Cell. Biol. |volume=18 |issue= 3 |pages= 1642-51 |year= 1998 |pmid= 9488481 |doi=  }}
* {{cite journal | vauthors = Page G, Lödige I, Kögel D, Scheidtmann KH | title = AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis | journal = FEBS Letters | volume = 462 | issue = 1-2 | pages = 187–91 | date = Nov 1999 | pmid = 10580117 | doi = 10.1016/S0014-5793(99)01529-X }}
*{{cite journal  | author=Saito T, Seki N, Ohira M, ''et al.'' |title=Assignment of the ZIP kinase gene to human chromosome 19p13.3 by somatic hybrid analysis and fluorescence in-situ hybridization. |journal=J. Hum. Genet. |volume=43 |issue= 3 |pages= 209-11 |year= 1998 |pmid= 9747039 |doi= }}
* {{cite journal | vauthors = Page G, Kögel D, Rangnekar V, Scheidtmann KH | title = Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis | journal = Oncogene | volume = 18 | issue = 51 | pages = 7265–73 | date = Dec 1999 | pmid = 10602480 | doi = 10.1038/sj.onc.1203170 }}
*{{cite journal | author=Murata-Hori M, Suizu F, Iwasaki T, ''et al.'' |title=ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells. |journal=FEBS Lett. |volume=451 |issue= 1 |pages= 81-4 |year= 1999 |pmid= 10356987 |doi= }}
* {{cite journal | vauthors = Cariou B, Perdereau D, Cailliau K, Browaeys-Poly E, Béréziat V, Vasseur-Cognet M, Girard J, Burnol AF | title = The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta | journal = Molecular and Cellular Biology | volume = 22 | issue = 20 | pages = 6959–70 | date = Oct 2002 | pmid = 12242277 | pmc = 139806 | doi = 10.1128/MCB.22.20.6959-6970.2002 }}
*{{cite journal | author=Page G, Lödige I, Kögel D, Scheidtmann KH |title=AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis. |journal=FEBS Lett. |volume=462 |issue= 1-2 |pages= 187-91 |year= 2000 |pmid= 10580117 |doi= }}
* {{cite journal | vauthors = Preuss U, Landsberg G, Scheidtmann KH | title = Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase | journal = Nucleic Acids Research | volume = 31 | issue = 3 | pages = 878–85 | date = Feb 2003 | pmid = 12560483 | pmc = 149197 | doi = 10.1093/nar/gkg176 }}
*{{cite journal | author=Page G, Kögel D, Rangnekar V, Scheidtmann KH |title=Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis. |journal=Oncogene |volume=18 |issue= 51 |pages= 7265-73 |year= 2000 |pmid= 10602480 |doi= 10.1038/sj.onc.1203170 }}
* {{cite journal | vauthors = Kawai T, Akira S, Reed JC | title = ZIP kinase triggers apoptosis from nuclear PML oncogenic domains | journal = Molecular and Cellular Biology | volume = 23 | issue = 17 | pages = 6174–86 | date = Sep 2003 | pmid = 12917339 | pmc = 180930 | doi = 10.1128/MCB.23.17.6174-6186.2003 }}
*{{cite journal | author=Cariou B, Perdereau D, Cailliau K, ''et al.'' |title=The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta. |journal=Mol. Cell. Biol. |volume=22 |issue= 20 |pages= 6959-70 |year= 2002 |pmid= 12242277 |doi= }}
* {{cite journal | vauthors = Burch LR, Scott M, Pohler E, Meek D, Hupp T | title = Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1 | journal = Journal of Molecular Biology | volume = 337 | issue = 1 | pages = 115–28 | date = Mar 2004 | pmid = 15001356 | doi = 10.1016/j.jmb.2003.10.081 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Endo A, Surks HK, Mochizuki S, Mochizuki N, Mendelsohn ME | title = Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase | journal = The Journal of Biological Chemistry | volume = 279 | issue = 40 | pages = 42055–61 | date = Oct 2004 | pmid = 15292222 | doi = 10.1074/jbc.M403676200 }}
*{{cite journal | author=Preuss U, Landsberg G, Scheidtmann KH |title=Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase. |journal=Nucleic Acids Res. |volume=31 |issue= 3 |pages= 878-85 |year= 2003 |pmid= 12560483 |doi= }}
* {{cite journal | vauthors = Schaaf CP, Benzing J, Schmitt T, Erz DH, Tewes M, Bartram CR, Janssen JW | title = Novel interaction partners of the TPR/MET tyrosine kinase | journal = FASEB Journal | volume = 19 | issue = 2 | pages = 267–9 | date = Feb 2005 | pmid = 15546961 | doi = 10.1096/fj.04-1558fje }}
*{{cite journal | author=Kawai T, Akira S, Reed JC |title=ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. |journal=Mol. Cell. Biol. |volume=23 |issue= 17 |pages= 6174-86 |year= 2003 |pmid= 12917339 |doi= }}
* {{cite journal | vauthors = Yu H, Jiang D, Guo Z, Saiyin H, Guo J, Wang X, Yu L | title = TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3 | journal = International Journal of Andrology | volume = 28 | issue = 3 | pages = 163–70 | date = Jun 2005 | pmid = 15910542 | doi = 10.1111/j.1365-2605.2005.00522.x }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Shoval Y, Pietrokovski S, Kimchi A | title = ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene | journal = PLoS Genetics | volume = 3 | issue = 10 | pages = 1884–93 | date = Oct 2007 | pmid = 17953487 | pmc = 2041995 | doi = 10.1371/journal.pgen.0030180 }}
*{{cite journal | author=Burch LR, Scott M, Pohler E, ''et al.'' |title=Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1. |journal=J. Mol. Biol. |volume=337 |issue= 1 |pages= 115-28 |year= 2004 |pmid= 15001356 |doi= 10.1016/j.jmb.2003.10.081 }}
* {{cite journal | vauthors = Takamoto N, Komatsu S, Komaba S, Niiro N, Ikebe M | title = Novel ZIP kinase isoform lacks leucine zipper | journal = Archives of Biochemistry and Biophysics | volume = 456 | issue = 2 | pages = 194–203 | date = Dec 2006 | pmid = 17126281 | pmc = 2758612 | doi = 10.1016/j.abb.2006.09.026 }}
*{{cite journal | author=Endo A, Surks HK, Mochizuki S, ''et al.'' |title=Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase. |journal=J. Biol. Chem. |volume=279 |issue= 40 |pages= 42055-61 |year= 2004 |pmid= 15292222 |doi= 10.1074/jbc.M403676200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Schaaf CP, Benzing J, Schmitt T, ''et al.'' |title=Novel interaction partners of the TPR/MET tyrosine kinase. |journal=FASEB J. |volume=19 |issue= 2 |pages= 267-9 |year= 2005 |pmid= 15546961 |doi= 10.1096/fj.04-1558fje }}
*{{cite journal | author=Yu H, Jiang D, Guo Z, ''et al.'' |title=TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3. |journal=Int. J. Androl. |volume=28 |issue= 3 |pages= 163-70 |year= 2005 |pmid= 15910542 |doi= 10.1111/j.1365-2605.2005.00522.x }}
*{{cite journal | author=Takamoto N, Komatsu S, Komaba S, ''et al.'' |title=Novel ZIP kinase isoform lacks leucine zipper. |journal=Arch. Biochem. Biophys. |volume=456 |issue= 2 |pages= 194-203 |year= 2007 |pmid= 17126281 |doi= 10.1016/j.abb.2006.09.026 }}
}}
{{refend}}
{{refend}}
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[[Category:EC 2.7.11]]

Latest revision as of 18:14, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.[1][2]

Function

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.[2]

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.[3]

Interactions

DAPK3 has been shown to interact with PAWR[4] and Death associated protein 6.[4]

References

  1. ↑ Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis". Molecular and Cellular Biology. 18 (3): 1642–51. doi:10.1128/mcb.18.3.1642. PMC 108879. PMID 9488481.
  2. ↑ 2.0 2.1 "Entrez Gene: DAPK3 death-associated protein kinase 3".
  3. ↑ Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLoS Genetics. 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487.
  4. ↑ 4.0 4.1 Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.

Further reading


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